About: Interleukin-6 signalling in health and disease

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Interleukin-6 signalling in health and disease
Creator	Algül, Hana Bromberg, Jacqueline Justus, Roeb, Elke Rose-John, Stefan
source	PMC
abstract	Biochemically, interleukin-6 belongs to the class of four-helical cytokines. The cytokine can be synthesised and secreted by many cells. It acts via a cell surface-expressed interleukin-6 receptor, which is not signalling competent. This receptor, when complexed with interleukin-6, associates with the signalling receptor glycoprotein 130 kDa (gp130), which becomes dimerised and initiates intracellular signalling via the Janus kinase/signal transducer and activator of transcription and rat sarcoma proto oncogene/mitogen-activated protein kinase/phosphoinositide-3 kinase pathways. Physiologically, interleukin-6 is involved in the regulation of haematopoiesis and the coordination of the innate and acquired immune systems. Additionally, interleukin-6 plays an important role in the regulation of metabolism, in neural development and survival, and in the development and maintenance of various cancers. Although interleukin-6 is mostly regarded as a pro-inflammatory cytokine, there are numerous examples of protective and regenerative functions of this cytokine. This review will explain the molecular mechanisms of the, in part opposing, activities of the cytokine interleukin-6.
has issue date	2020-08-20(xsd:dateTime)
bibo:doi	10.12688/f1000research.26058.1
has license	cc-by
sha1sum (hex)	fdead6c510b195e0e9bcad53c292a874c6e562b1
schema:url	https://doi.org/10.12688/f1000research.26058.1
resource representing a document's title	Interleukin-6 signalling in health and disease
has PubMed Central identifier	PMC7443778
schema:publication	F1000Res
resource representing a document's body	covid:fdead6c510b195e0e9bcad53c292a874c6e562b1#body_text
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