About: Airway Interleukin-33 and type 2 cytokines in adult patients with acute asthma

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Airway Interleukin-33 and type 2 cytokines in adult patients with acute asthma
Creator	Khoo, Siew-Kim Laing, Ingrid Backer, Vibeke Baltic, Svetlana Barrett, Lucy Bjerregaard, Asger Le Souëf, Peter Porsbjerg, Celeste Poulsen, Nadia Cohen, Suzanne Rapley, Laura Thompson, Philip
Source	Elsevier; Medline; PMC
abstract	Abstract Background Several animal studies, and one inoculation study in adult asthmatics have shown that interleukin-33 (IL-33) is a major contributor to type-2 inflammation in acute asthma. However, the link between IL-33 and type-2 inflammation has not been shown in naturally occurring asthma exacerbations. Objectives To determine if airway IL-33 is associated with type-2 inflammation measured by type-2 cytokines, FeNO and sputum eosinophils in patients presenting to the Emergency Department with an asthma exacerbations. Methods Adult patients hospitalized due to acute asthma were enrolled. Upper airways were sampled with nasal swabs and lower airways with induced sputum. Cytokines were measured at protein level using a Luminex® assay and mRNA expression level using droplet-digital-PCR. Airway sampling was repeated four weeks after exacerbation. Results At the time of exacerbation, upper airway IL-33 correlated with upper airway IL-5 and IL-13 (R = 0.84, p < 0.01 and R = 0.76, p < 0.01, respectively) and with lower airway IL-13 (R = 0.49, p = 0.03). Similar associations were observed for mRNA expression. Lower airway IL-33 positively correlated with lower airway IL-13 (R = 0.84, p < 0.01). IL-13 and IL-33 were positively correlated with FeNO, and IL-5 with eosinophils. The association between IL-33 and type-2 cytokines were still present four weeks after exacerbation. Conclusion This is the first study to demonstrate that airway IL-33 is associated with type-2 cytokines in naturally occurring asthma exacerbations in adults, providing in vivo evidence supporting that IL-33 may be driving type-2 inflammation in acute asthma. Thus supporting IL-33 as a potential future drug target due to its role, upstream in the immunological cascade.
has issue date	2018-07-31(xsd:dateTime)
bibo:doi	10.1016/j.rmed.2018.05.016
bibo:pmid	29957280
has license	els-covid
sha1sum (hex)	fe00f479396b82f2ab95abadb67f2c7881bb0776
schema:url	https://doi.org/10.1016/j.rmed.2018.05.016
resource representing a document's title	Airway Interleukin-33 and type 2 cytokines in adult patients with acute asthma
has PubMed Central identifier	PMC7172141
has PubMed identifier	29957280
schema:publication	Respiratory Medicine
resource representing a document's body	covid:fe00f479396b82f2ab95abadb67f2c7881bb0776#body_text
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