About: Acute adrenal infarction as an incidental CT finding and a potential prognosis factor in severe SARS-CoV-2 infection: a retrospective cohort analysis on 219 patients

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About: Acute adrenal infarction as an incidental CT finding and a potential prognosis factor in severe SARS-CoV-2 infection: a retrospective cohort analysis on 219 patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Acute adrenal infarction as an incidental CT finding and a potential prognosis factor in severe SARS-CoV-2 infection: a retrospective cohort analysis on 219 patients
Creator	Meziani, Ferhat Ohana, Mickaël Riou, Marianne Roy, Catherine Leyendecker, Pierre Ritter, Sébastien Wackenthaler, Antoine
source	Medline; PMC
abstract	OBJECTIVES: To retrospectively investigate the incidence of acute adrenal infarction (AAI) in patients who underwent chest CT for severe SARS-CoV-2 infection and to correlate findings with prognosis. METHODS: The local ethics committee approved this retrospective study and waived the need of informed consent. From March 9 to April 10, 2020, all patients referred to our institution for a clinical suspicion of COVID-19 with moderate to severe symptoms underwent a chest CT for triage. Patients with a/parenchymal lesion characteristics of COVID-19 involving at least 50% of lung parenchyma and b/positive RT-PCR for SARS-CoV-2 were retrospectively included. Adrenal glands were reviewed by two independent readers to look for AAI. Additional demographics and potential biological markers of adrenal insufficiency were obtained. Correlations with ICU stay and mortality were sought. RESULTS: Out of the 219 patients with critical (n = 52) and severe lung (n = 167) parenchyma lesions, 51 (23%) had CT scan signs of AAI, which was bilateral in 45 patients (88%). Four patients had an acute biological adrenal gland insufficiency (8%). Univariate analysis in AAI+ patients demonstrated a higher rate of ICU stay (67% vs. 45%, p < 0.05) and a longer stay (more than 15 days for 31% for AAI+ vs. 19%, p < 0.05) compared with AAI− patients. Mortality rate was similar (27%, p = 0.92). CONCLUSIONS: Acute adrenal infarction on initial chest evaluation of severe COVID-19 is frequent (51/219, 23%) and might be a sign of poorer prognosis. KEY POINTS: • Acute adrenal infarction on initial chest CT evaluation of severe COVID-19 is frequent (51/219). • AAI might be a factor of poorer prognosis, with increased rate of ICU hospitalization and length of stay.
has issue date	2020-08-27(xsd:dateTime)
bibo:doi	10.1007/s00330-020-07226-5
bibo:pmid	32852586
has license	no-cc
sha1sum (hex)	fe17470e24e5142bf117bb5f797fa6d77f11bdbf
schema:url	https://doi.org/10.1007/s00330-020-07226-5
resource representing a document's title	Acute adrenal infarction as an incidental CT finding and a potential prognosis factor in severe SARS-CoV-2 infection: a retrospective cohort analysis on 219 patients
has PubMed Central identifier	PMC7450155
has PubMed identifier	32852586
schema:publication	Eur Radiol
resource representing a document's body	covid:fe17470e24e5142bf117bb5f797fa6d77f11bdbf#body_text
is schema:about of	named entity 'stay' named entity 'severe' named entity 'prognosis' named entity 'infarction' named entity 'COVID-19' named entity 'patients' named entity 'retrospective cohort' named entity 'INDEPENDENT' named entity 'ADRENAL INSUFFICIENCY' named entity 'patients' named entity 'AAI' named entity 'symptoms' named entity 'AAI' named entity 'The' named entity 'March' named entity 'AAI' named entity 'lesion' named entity 'evaluation' named entity 'waived' named entity 'severe' named entity 'infarction' named entity 'informed consent' named entity 'infarction' named entity 'triage' named entity 'prognosis' named entity 'Adrenal glands' named entity 'Univariate analysis' named entity 'RT-PCR' named entity 'chest CT' named entity 'chest CT' named entity 'ICU' named entity 'SARS-CoV-2' named entity 'chest CT' named entity 'prognosis' named entity 'France' named entity 'pathological conditions' named entity 'follow-up' named entity 'outpatient' named entity 'MRI' named entity 'SARS in 2003' named entity 'follow-up' named entity 'COVID' named entity 'adrenal gland' named entity 'infarcted' named entity 'C.R.' named entity 'ground glass opacities' named entity 'chest CT' named entity 'systemic inflammatory response syndrome' named entity 'lung parenchyma' named entity 'SARS-CoV-2' named entity 'adrenal gland' named entity 'hyponatremia' named entity 'infarct' named entity 'chest CT' named entity 'lung parenchyma' named entity 'HPA' named entity 'informed consent' named entity 'Gaussian distribution' named entity 'adrenal gland' named entity 'BMI' named entity 'adrenal glands' named entity 'M.O.' named entity 'hemorrhagic' named entity 'chest CT' named entity 'coronavirus' named entity 'mortality rate' named entity 'immunosuppression' named entity 'quantile-quantile plot' named entity 'evidence-based approaches' named entity 'parenchymal' named entity 'Statistical analyses' named entity 'immune response' named entity 'CT scans' named entity 'adrenal gland' named entity 'viral load'

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