About: The SARS-Coronavirus PLnc domain of nsp3 as a replication/transcription scaffolding protein

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About: The SARS-Coronavirus PLnc domain of nsp3 as a replication/transcription scaffolding protein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The SARS-Coronavirus PLnc domain of nsp3 as a replication/transcription scaffolding protein
Creator	Canard, Bruno Imbert, Isabelle Guillemot, Jean-Claude Lécine, Patrick Dimitrova, Maria Snijder, Eric
Source	Elsevier; Medline; PMC
abstract	Abstract Many genetic and mechanistic features distinguish the coronavirus replication machinery from that encoded by most other RNA viruses. The coronavirus replication/transcription complex is an assembly of viral and, most probably, cellular proteins that mediate the synthesis of both the unusually large (∼30kb) RNA genome and an extensive set of subgenomic mRNAs. The viral components of the complex are encoded by the giant replicase gene, which is expressed in the form of two polyproteins (pp1a and pp1ab) that are processed into 16 cleavage products (nonstructural proteins 1–16). Using the combination of yeast two-hybrid screening and GST pull-down assays, we have now analyzed all potential interactions between SARS-Coronavirus nonstructural proteins, which may contribute to the structure and/or function of the viral replication/transcription complex. We demonstrate the existence of a complex network of interactions involving all 16 nonstructural proteins. Our results both confirmed previously described associations and identified novel heterodimerizations. The interaction map thus provides a sum of the interactions that may occur at some point during coronavirus RNA synthesis and provides a framework for future research.
has issue date	2008-05-31(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2007.11.017
bibo:pmid	18255185
has license	els-covid
sha1sum (hex)	fe2d27812b872d33ef88ce9774ffaeab9aac842e
schema:url	https://doi.org/10.1016/j.virusres.2007.11.017
resource representing a document's title	The SARS-Coronavirus PLnc domain of nsp3 as a replication/transcription scaffolding protein
has PubMed Central identifier	PMC7114086
has PubMed identifier	18255185
schema:publication	Virus Research
resource representing a document's body	covid:fe2d27812b872d33ef88ce9774ffaeab9aac842e#body_text
is schema:about of	named entity 'complex network' named entity 'encoded' named entity 'complex' named entity 'assays' named entity 'RNA' named entity 'RNA GENOME' named entity 'MAP' named entity 'SARS' named entity 'COMBINATION' named entity 'REPLICASE' named entity 'INTERACTIONS' named entity 'DESCRIBED' named entity 'TWO-HYBRID SCREENING' named entity 'POINT' named entity 'FUTURE' named entity 'SET' named entity 'RNA VIRUSES' named entity 'CLEAVAGE' named entity 'LARGE' named entity 'NONSTRUCTURAL PROTEINS' named entity 'NOVEL' named entity 'MRNAS' named entity 'CONFIRMED' named entity 'GIANT' named entity 'CONTRIBUTE ' named entity 'PROTEINS' named entity 'HAVE' named entity 'PROCESSED' named entity 'SUM' named entity 'OUR' named entity 'PULL' named entity 'POTENTIAL' named entity 'SARS' named entity 'FORM' named entity 'RESULTS' named entity 'PROVIDES' named entity 'CELLULAR' named entity 'COMPLEX' named entity 'GST' named entity 'GENETIC' named entity 'VIRAL AND' named entity 'MACHINERY' named entity 'ENCODED' named entity 'STRUCTURE' named entity 'OCCUR' named entity 'NETWORK' named entity 'GENE' named entity 'DOMAIN' named entity 'REPLICATION' named entity 'NSP3' named entity 'FEATURES' named entity 'RNA SYNTHESIS' named entity 'SCAFFOLDING PROTEIN' named entity 'ASSOCIATIONS' named entity 'PROBABLY' named entity 'FUNCTION' named entity 'YEAST TWO-HYBRID' named entity 'CORONAVIRUS' named entity 'PRODUCTS' named entity 'EXTENSIVE' named entity 'INTERACTION' named entity 'POLYPROTEINS' named entity 'USING' named entity 'VIRAL COMPONENTS' named entity 'EXPRESSED' named entity 'INVOLVING' named entity 'SYNTHESIS' named entity 'IDENTIFIED' named entity 'MEDIATE' named entity 'VIRAL REPLICATION' named entity 'ANALYZED' named entity 'PREVIOUSLY' named entity 'RESEARCH' named entity 'ASSEMBLY' covid:arg/fe2d27812b872d33ef88ce9774ffaeab9aac842e named entity 'subgenomic'

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