About: Clinical characteristics and drug therapies in patients with the common-type coronavirus disease 2019 in Hunan, China

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Clinical characteristics and drug therapies in patients with the common-type coronavirus disease 2019 in Hunan, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical characteristics and drug therapies in patients with the common-type coronavirus disease 2019 in Hunan, China
Creator	Wang, Ling Chen, · Huang, Qiong Xie, Mingxuan Deng, Xuanyu Gefei He, · Li, Yongzhong Liu, Shouxian Qu, · Shao Liu, · Sun, Xuexiong Zhicheng Gong, ·
Source	Medline; PMC
abstract	Background Clinical characteristics of patients with the coronavirus disease 2019 (COVID-19) may present differently within and outside the epicenter of Wuhan, China. More clinical investigations are needed. Objective The study was aimed to describe the clinical characteristics, laboratory parameters, and therapeutic methods of COVID-19 patients in Hunan, China. Setting The First Hospital of Changsha, First People’s Hospital of Huaihua, and the Central Hospital of Loudi, Hunan province, China. Methods This was a retrospective multi-center case-series analysis. Patients with confirmed COVID-19 diagnosis hospitalized at the study centers from January 17 to February 10, 2020, were included. The following data were obtained from electronic medical records: demographics, medical history, exposure history, underlying comorbidities, symptoms, signs, laboratory findings, computer tomography scans, and treatment measures. Main outcome measure Epidemiological, clinical, laboratory, and radiological characteristics and treatments. Results A total of 54 patients were included (51 had the common-type COVID-19, three had the severe-type), the median age was 41, and 52% of them were men. The median time from the first symptoms to hospital admission was seven days. Among patients with the common-type COVID-19, the median length of stay was nine days, and 21 days among patients with severe COVID-19. The most common symptoms at the onset of illness were fever (74.5%), cough (56.9%), and fatigue (43.1%) among patients in the common-type group. Fourteen patients (37.8%) had a reduced WBC count, 23 (62.2%) had reduced eosinophil ratio, and 21 (56.76%) had decreased eosinophil count. The most common patterns on chest-computed tomography were ground-glass opacity (52.2%) and patchy bilateral shadowing (73.9%). Pharmacotherapy included recombinant human interferon α2b, lopinavir/ritonavir, novaferon, antibiotics, systematic corticosteroids and traditional Chinese medicine prescription. The outcome of treatment indicated that in patients with the common-type COVID-19, interferon-α2b, but not novaferon, had some benefits, antibiotics treatment was not needed, and corticosteroids should be used cautiously. Conclusion As of February 10, 2020, the symptoms of COVID-19 patients in Hunan province were relatively mild comparing to patients in Wuhan, the epicenter. We observed some treatment benefits with interferon-α2b and corticosteroid therapies but not with novaferon and antibiotic treatment in our study population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11096-020-01031-2) contains supplementary material, which is available to authorized users.
has issue date	2020-05-14(xsd:dateTime)
bibo:doi	10.1007/s11096-020-01031-2
bibo:pmid	32410206
has license	no-cc
sha1sum (hex)	fea95dd6530dbf27762a446a22668687d6c53765
schema:url	https://doi.org/10.1007/s11096-020-01031-2
resource representing a document's title	Clinical characteristics and drug therapies in patients with the common-type coronavirus disease 2019 in Hunan, China
has PubMed Central identifier	PMC7221339
has PubMed identifier	32410206
schema:publication	Int J Clin Pharm
resource representing a document's body	covid:fea95dd6530dbf27762a446a22668687d6c53765#body_text
is schema:about of	named entity 'Patients' named entity 'coronavirus disease 2019' named entity 'clinical investigations' named entity 'comorbidities' named entity 'needed' named entity 'median' named entity 'Pharmacotherapy' named entity 'medical history' named entity 'epicenter' named entity 'describe' named entity 'China' covid:arg/fea95dd6530dbf27762a446a22668687d6c53765 named entity 'data' named entity 'ground-glass opacity' named entity 'symptoms' named entity 'cough' named entity 'patients' named entity 'days' named entity 'Huaihua' named entity 'Hunan' named entity 'needed' named entity 'fatigue' named entity 'More' named entity 'First People' named entity 'lopinavir/ritonavir' named entity 'COVID-19' named entity 'radiological' named entity 'demographics' named entity 'corticosteroid' named entity 'eosinophil' named entity 'COVID-19' named entity 'COVID-19' named entity 'hospital admission' named entity 'computed tomography' named entity 'interferon-α2b' named entity 'recombinant' named entity 'antibiotic treatment' named entity 'antibiotics' named entity 'antibiotics' named entity 'corticosteroids' named entity 'ground-glass opacity' named entity 'Hunan' named entity 'China' named entity 'clinical investigations' named entity 'lopinavir/ritonavir' named entity 'COVID' named entity 'Hunan' named entity 'coronavirus disease 2019' named entity 'α2b' named entity 'Mann-Whitney' named entity 'antiviral treatment' named entity 'electrolyte' named entity 'antibiotic treatment' named entity 'bile acid' named entity 'blood test results' named entity 'blood urea nitrogen' named entity 'virus' named entity 'COVID-19' named entity 'bacteria' named entity 'fever' named entity 'SARS-CoV-2' named entity 'pulmonary fibrosis' named entity 'Wuhan' named entity 'infection' named entity 'follow-up' named entity 'COVID' named entity 'cough' named entity 'PCR reaction' named entity 'COVID' named entity 'clinical characteristics'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software