About: Severe influenza A(H1N1)pdm09 in pregnant women and neonatal outcomes, State of Sao Paulo, Brazil, 2009

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About: Severe influenza A(H1N1)pdm09 in pregnant women and neonatal outcomes, State of Sao Paulo, Brazil, 2009 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Severe influenza A(H1N1)pdm09 in pregnant women and neonatal outcomes, State of Sao Paulo, Brazil, 2009
Creator	Madalosso, Geraldine Marques, Daniel Fred, Joao Kitagawa, Beatriz Regina, Telma Ribeiro, Ana Trevisan, Maria Albernaz, Albernaz, Mangabeira Beatriz, Yuko Carvalhanas, Marques Cristina, Alessandra Dirce, Maria Fred, Ricardo Kerti, Mangabeira Kerti, Ricardo Kita-Gawa, Daniel Madalosso, Joao Marques, Geraldine Pellini, Guedes Pinto, Marques Zanetta,
Source	PMC
abstract	To investigate the factors associated with death and describe the gestational outcomes in pregnant women with influenza A(H1N1)pdm09, we conducted a case-control study (deaths and recovered) in hospitalized pregnant women with laboratory-confirmed influenza A(H1N1)pdm09 with severe acute respiratory illness (SARI) in the state of São Paulo from June 9 to December 1, 2009. All cases were evaluated, and four controls that were matched by the epidemiological week of hospitalization of the case were randomly selected for each case. Cases and controls were selected from the National Disease Notification System-SINAN Influenza-web. The hospital records from 126 hospitals were evaluated, and home interviews were conducted using standardized forms. A total of 48 cases and 185 controls were investigated. Having had a previous health visit to a healthcare provider for an influenza episode before hospital admission was a risk factor for death (adjusted OR (OR(adj)) of 7.93, 95% CI 2.19–28.69). Although not significant in the multiple analysis (OR(adj) of 2.13, 95% CI 0.91–5.00), the 3(rd) trimester deserves attention, with an OR = 2.22, 95% CI 1.13–4.37 in the univariate analysis. Antiviral treatment was a protective factor when administered within 48 hours of symptom onset (OR(adj) = 0.16, 95% CI 0.05–0.50) and from 48 to 72 hours (OR(adj) = 0.09, 95% CI 0.01–0.87). There was a higher proportion of fetal deaths and preterm births among cases (p = 0.001) and live births with low weight (p = 0.019), compared to control subjects who gave birth during hospitalization. After discharge, control subjects had a favorable neonatal outcome. Early antiviral treatment during the presence of a flu-like illness is an important factor in reducing mortality from influenza in pregnant women and unfavorable neonatal outcomes. It is important to monitor pregnant women, particularly in the 3(rd) trimester of gestation, with influenza illness for diagnosis and early treatment.
has issue date	2018-03-26(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0194392
bibo:pmid	29579099
has license	cc-by
sha1sum (hex)	feb72aaab347ff388a21fc4d96575c5cbf29c020
schema:url	https://doi.org/10.1371/journal.pone.0194392
resource representing a document's title	Severe influenza A(H1N1)pdm09 in pregnant women and neonatal outcomes, State of Sao Paulo, Brazil, 2009
has PubMed Central identifier	PMC5868799
has PubMed identifier	29579099
schema:publication	PLoS One
resource representing a document's body	covid:feb72aaab347ff388a21fc4d96575c5cbf29c020#body_text
is schema:about of	named entity 'proportion' named entity 'control' named entity 'conducted' named entity 'evaluated' named entity 'case' named entity 'FETAL DEATHS' named entity 'WEB' named entity 'WAS A' named entity 'NEONATAL' named entity 'HEALTHCARE PROVIDER' named entity 'FLU-LIKE ILLNESS' named entity 'GAVE' named entity '0.09' named entity 'DISEASE NOTIFICATION' named entity '126' named entity 'CONTROL' named entity 'IMPORTANT' named entity 'SELECTED' named entity 'PROPORTION' named entity 'ATTENTION' named entity 'HOSPITALIZATION' named entity 'PREGNANT WOMEN' named entity 'INFLUENZA A' named entity 'INVESTIGATED' named entity 'DISCHARGE' named entity 'ANTIVIRAL TREATMENT' named entity 'FAVORABLE' named entity 'CONFIRMED' named entity 'HOSPITALS' named entity 'PRESENCE OF' named entity 'GESTATIONAL' named entity 'CASES' named entity 'PRETERM BIRTHS' named entity 'TRIMESTER' named entity 'NOT SIGNIFICANT' named entity 'TO INVESTIGATE' named entity 'HOME' named entity '185' named entity 'TOTAL' named entity 'HOSPITAL RECORDS' named entity 'PROTECTIVE FACTOR' named entity 'CASE' named entity 'WEEK' named entity '0.001' named entity 'OUTCOMES' named entity 'TO CONTROL' named entity 'EARLY TREATMENT' named entity 'COMPARED' named entity 'MONITOR' named entity 'STATE' named entity 'DESCRIBE' named entity 'HOSPITALIZED' named entity '28P' named entity 'PREVIOUS' named entity 'FOR DIAGNOSIS' named entity '0.05' named entity 'DURING HOSPITALIZATION' named entity 'RISK FACTOR' named entity 'ASSOCIATED WITH' named entity 'LABORATORY'

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