About: Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds

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About: Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds
Creator	Lin, Cheng-Wen Wan, Lei Ho, Tin-Yun Lai, Chien-Chen Tsai, Fuu-Jen Hsieh, Chang-Chi Tsai, Chang-Hai Chao, Pei-Dawn
Source	Elsevier; Medline; PMC
abstract	Abstract The 3C-like protease (3CLpro) of SARS-coronavirus mediates the proteolytic processing of replicase polypeptides 1a and 1ab into functional proteins, becoming an important target for the drug development. In this study, Isatis indigotica root extract, five major compounds of I. indigotica root, and seven plant-derived phenolic compounds were tested for anti-SARS-CoV 3CLpro effects using cell-free and cell-based cleavage assays. Cleavage assays with the 3CLpro demonstrated that IC50 values were in micromolar ranges for I. indigotica root extract, indigo, sinigrin, aloe emodin and hesperetin. Sinigrin (IC50: 217μM) was more efficient in blocking the cleavage processing of the 3CLpro than indigo (IC50: 752μM) and beta-sitosterol (IC50: 1210μM) in the cell-based assay. Only two phenolic compounds aloe emodin and hesperetin dose-dependently inhibited cleavage activity of the 3CLpro, in which the IC50 was 366μM for aloe emodin and 8.3μM for hesperetin in the cell-based assay.
has issue date	2005-10-31(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2005.07.002
bibo:pmid	16115693
has license	els-covid
sha1sum (hex)	fec5f908de12a2d95ef4c09ad412b1ae2f0591b0
schema:url	https://doi.org/10.1016/j.antiviral.2005.07.002
resource representing a document's title	Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds
has PubMed Central identifier	PMC7114321
has PubMed identifier	16115693
schema:publication	Antiviral Research
resource representing a document's body	covid:fec5f908de12a2d95ef4c09ad412b1ae2f0591b0#body_text
is schema:about of	named entity 'LIKE' named entity 'hesperetin' named entity 'polypeptides' named entity 'PROTEASE' named entity 'POLYPEPTIDES' named entity 'DRUG DEVELOPMENT' named entity 'CELL' named entity 'INDIGO' named entity 'DERIVED' named entity 'CORONAVIRUS' named entity 'DOSE' named entity 'SINIGRIN' named entity 'PRO' named entity 'ISATIS INDIGOTICA' covid:arg/fec5f908de12a2d95ef4c09ad412b1ae2f0591b0 named entity 'ROOT' named entity 'REPLICASE' named entity 'ROOT' named entity 'PHENOLIC' named entity 'DERIVED' named entity 'SARS CORONAVIRUS' named entity 'PLANT-' named entity 'ISATIS INDIGOTICA' named entity 'EFFECTS' named entity 'ALOE EMODIN' named entity 'LIKE' named entity 'EXTRACT' named entity 'CLEAVAGE' named entity 'TARGET' named entity 'BLOCKING' named entity '217' named entity 'EFFICIENT' named entity 'MICROMOLAR' named entity 'TESTED FOR' named entity 'PROTEASE' named entity 'SARS' named entity 'SARS-COV' named entity 'PROTEOLYTIC PROCESSING' named entity 'HESPERETIN' named entity 'VALUES' named entity 'PROTEINS' named entity 'CELL-BASED ASSAY' named entity 'DEMONSTRATED' named entity 'USING' named entity 'STUDY' named entity 'PLANT-' named entity 'FUNCTIONAL' named entity 'ACTIVITY' named entity 'EFFECTS' named entity 'MEDIATES' named entity 'IMPORTANT' named entity 'BETA-SITOSTEROL' named entity 'SEVEN' named entity 'INHIBITED' named entity 'MAJOR' named entity 'BASED' named entity 'PROCESSING' named entity 'FREE' named entity '752' named entity 'PHENOLIC' named entity 'aloe emodin' named entity 'proteins' named entity 'extract' named entity 'blocking' named entity 'assay' named entity 'pro' named entity 'hesperetin' named entity 'phenolic compounds' named entity 'phenolic compounds' named entity 'aloe emodin' named entity '8.3' named entity 'SARS' named entity 'beta-sitosterol' named entity 'Isatis indigotica'

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