About: Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses

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About: Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses
Creator	Li, S Baric, Y Chang, S Eisfeld, V Fan, S Gralinski, J Green, C Josset, A Katze, K Kawaoka, M Long, L Matzke, J Menachery, Citation Metz, A Neumann, C Proll, A Schepmoes, B-J Schäfer, A Shukla, A Sims, L Smith, T Tilton, G Waters, R Webb-Robertson, M Weiss, C Williams, R
Source	Medline; PMC
abstract	The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet to be examined. Employing models of the human airway, transcriptomics and proteomics datasets were used to compare ISG response patterns following highly pathogenic H5N1 avian influenza (HPAI) A virus, 2009 pandemic H1N1, severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome CoV (MERS-CoV) infection. The results illustrated distinct approaches utilized by each virus to antagonize the global ISG response. In addition, the data revealed that highly virulent HPAI virus and MERS-CoV induce repressive histone modifications, which downregulate expression of ISG subsets. Notably, influenza A virus NS1 appears to play a central role in this histone-mediated downregulation in highly pathogenic influenza strains. Together, the work demonstrates the existence of unique and common viral strategies for controlling the global ISG response and provides a novel avenue for viral antagonism via altered histone modifications.
has issue date	2014-05-20(xsd:dateTime)
bibo:doi	10.1128/mbio.01174-14
bibo:pmid	24846384
has license	cc-by-nc-sa
sha1sum (hex)	fef0bb9eaac69559d0ff2f92ff83e0affd4435f0
schema:url	https://doi.org/10.1128/mbio.01174-14
resource representing a document's title	Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses
has PubMed Central identifier	PMC4030454
has PubMed identifier	24846384
schema:publication	mBio
resource representing a document's body	covid:fef0bb9eaac69559d0ff2f92ff83e0affd4435f0#body_text
is schema:about of	named entity 'TO BE EXAMINED' named entity 'HIGHLY' named entity 'VIRAL' named entity 'GENES' named entity 'TO COMPARE' named entity 'DIVERSITY' named entity 'EMPLOYING' named entity 'INDIVIDUAL' named entity 'RESPIRATORY VIRUSES' named entity 'AIRWAY' named entity 'RESPONSE' named entity 'BROAD' named entity 'OVERCOME' named entity 'SUCCESSFUL' named entity 'GLOBAL' named entity 'ISG' named entity 'proteomics' named entity 'viral' named entity 'overcome' named entity 'Viruses' named entity 'SIMILAR' named entity 'INFLUENZA VIRUSES' named entity 'TO CONTROL' named entity 'RESPONSES' named entity 'INTERFERON' named entity 'INTERFERON' named entity 'STIMULATED' named entity 'MODELS' named entity 'RANGE' named entity 'HOST' named entity 'PATHOGENIC' named entity 'GENE' named entity 'CONTRASTING' named entity 'PATHOGENIC' named entity 'CORONAVIRUSES' named entity 'STIMULATED' named entity 'APPROACHES' named entity 'TRANSCRIPTOMICS' named entity 'INDUCE' named entity 'VIRAL PATHOGENESIS' named entity 'FUNCTION' named entity 'PATTERNS' named entity 'ANTIVIRAL' named entity 'PROTEOMICS' named entity 'SUBSEQUENT' named entity 'ANALYSIS' named entity 'ANTAGONISM' named entity 'FOLLOWING' named entity 'IMPEDING' named entity 'HUMAN' named entity 'USED' named entity 'STATE' named entity 'H5N1' named entity 'AVIAN INFLUENZA' named entity 'The broad' named entity 'pathogenic'

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