About: ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments

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About: ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments
Creator	Tordo, Noël Le Grand, Roger Davey, Robert Aubenque, Céline Barbier, Julien Bouclier, Céline Boulogne, Claire Cintrat, Jean-Christophe Clayette, Pascal Cojean, Sandrine Fischer, Annette Gillet, Cynthia Gillet, Daniel Gobbo, Emilie Goudet, Amélie Herweg, Jo-Ana Kali, Sabrina Laporte, Jérôme Lemichez, Emmanuel Lopez, Roman Merer, Goulven Panigai, Laetitia Pons, Valérie Rudel, Thomas Sauvaire, Didier Wu, Yu Yousfi, Rahima Loiseau, Philippe Popoff, Michel
source	Medline; PMC
abstract	Intracellular pathogenic microorganisms and toxins exploit host cell mechanisms to enter, exert their deleterious effects as well as hijack host nutrition for their development. A potential approach to treat multiple pathogen infections and that should not induce drug resistance is the use of small molecules that target host components. We identified the compound 1-adamantyl (5-bromo-2-methoxybenzyl) amine (ABMA) from a cell-based high throughput screening for its capacity to protect human cells and mice against ricin toxin without toxicity. This compound efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. ABMA provokes Rab7-positive late endosomal compartment accumulation in mammalian cells without affecting other organelles (early endosomes, lysosomes, the Golgi apparatus, the endoplasmic reticulum or the nucleus). As the mechanism of action of ABMA is restricted to host-endosomal compartments, it reduces cell infection by pathogens that depend on this pathway to invade cells. ABMA may represent a novel class of broad-spectrum compounds with therapeutic potential against diverse severe infectious diseases.
has issue date	2017-11-14(xsd:dateTime)
bibo:doi	10.1038/s41598-017-15466-7
bibo:pmid	29138439
has license	cc-by
sha1sum (hex)	ff026fb53971d5bfa70c0b9b017d011cc7deee0e
schema:url	https://doi.org/10.1038/s41598-017-15466-7
resource representing a document's title	ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments
has PubMed Central identifier	PMC5686106
has PubMed identifier	29138439
schema:publication	Sci Rep
resource representing a document's body	covid:ff026fb53971d5bfa70c0b9b017d011cc7deee0e#body_text
is schema:about of	named entity 'late' named entity 'pathogenic' named entity 'depend' named entity 'mechanisms' named entity 'positive' named entity 'This' named entity 'OPEN' named entity 'pathogens' named entity 'LATE' named entity 'INTRACELLULAR' named entity 'ABMA' covid:arg/ff026fb53971d5bfa70c0b9b017d011cc7deee0e named entity 'AFFECTING' named entity 'ENDOPLASMIC RETICULUM' named entity 'RESTRICTED' named entity 'ENTER' named entity 'APPROACH' named entity 'COMPOUND' named entity 'ITS' named entity 'TARGET' named entity 'BROMO' named entity 'INFECTION' named entity 'DRUG RESISTANCE' named entity 'DEVELOPMENT' named entity 'IDENTIFIED' named entity 'PATHOGEN' named entity 'CELL' named entity 'HUMAN CELLS' named entity 'REPRESENT' named entity 'COMPARTMENT' named entity 'DEPEND' named entity 'CELLS' named entity 'COMPARTMENTS' named entity 'INCLUDING' named entity 'PATHOGENIC' named entity 'MICROORGANISMS' named entity 'BACTERIA ' named entity 'ENDOSOMES' named entity 'VIRUSES' named entity 'HOST' named entity 'GOLGI APPARATUS' named entity 'SMALL MOLECULES' named entity 'INDUCE' named entity 'INTRACELLULAR BACTERIA' named entity 'NUCLEUS' named entity 'MAMMALIAN' named entity 'PATHWAY' named entity 'MECHANISM OF ACTION' named entity 'COMPONENTS' named entity 'RICIN TOXIN' named entity 'AMINE' named entity 'PATHOGENS' named entity 'MULTIPLE'

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