About: Risk for HIV-1 infection is not associated with Repeat-Region polymorphism in the DC-SIGN neck domain and Novel Genetic DC-SIGN Variants among North Indians

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Risk for HIV-1 infection is not associated with Repeat-Region polymorphism in the DC-SIGN neck domain and Novel Genetic DC-SIGN Variants among North Indians Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Risk for HIV-1 infection is not associated with Repeat-Region polymorphism in the DC-SIGN neck domain and Novel Genetic DC-SIGN Variants among North Indians
Creator	Sood, Vikas Banerjea, Akhil Chatterjee, Animesh Dhole, Tapan Rathore, Anurag Yamamoto, Naohiko Khan, Sohrab
Source	Elsevier; Medline; PMC
abstract	Abstract Background Several genetic factors have been related to HIV-1 resistance, the homozygosity for a mutation in CCR5 gene (CCR5Δ 32 allele) is presently considered the most relevant one. The C-type lectin, DC-SIGN efficiently binds and transmits HIV-1 to susceptible cell in trans thereby augmenting the infection. A potential association of the DC-SIGN neck domain repeats polymorphism and risk of HIV-1 infection is currently under debate. Methods Genetic risk association study was conducted in HIV-1 exposed seronegative (HES; n =50) individuals, HIV-1 seronegative (HSN; n =314) healthy control and HIV-1 infected seropositive patients (HSP; n =190) for polymorphism in neck domain of DC-SIGN gene. The DC-SIGN genotypes were identified by PCR from DNA extracted from peripheral blood and confirmed by sequencing. Fisher exact or χ2 test was used for statistical analysis. Results One HSN and HSP individual who were heterozygous (7/8) with respect to DC-SIGN repeat regions were found. The DC-SIGN neck repeat polymorphism among North Indian individuals was not associated with susceptibility to HIV-1 infection. Furthermore, inheritance study of heterozygous mutation (7/8) in HSN individual's family showed that one parent, two brothers, one sister and one daughter were heterozygous (7/8) for DC-SIGN mutant allele. Sequence analyses of DC-SIGN exon 4 repeat region of randomly selected 25 North Indian individuals from HSP, HSN and HES revealed four conserved intronic mutations. These mutations were at nucleotide position 1283, 1306, 1308 upstream and 1906 downstream of the DC-SIGN exon 4 repeat region when compared with the wild type sequence (NCBI Acc. No. AF209479). Conclusion The polymorphism in DC-SIGN neck repeats region was rare and not associated with HIV-1 susceptibility among North Indians. Sequencing analysis of DC-SIGN gene confirmed four novel genetic variants in intronic region flanking exon 4 coding region.
has issue date	2008-05-31(xsd:dateTime)
bibo:doi	10.1016/j.cca.2007.12.019
bibo:pmid	18255039
has license	els-covid
sha1sum (hex)	ff1dcf0a1deb1d323bd0b6a71f496d7a8a9c97f1
schema:url	https://doi.org/10.1016/j.cca.2007.12.019
resource representing a document's title	Risk for HIV-1 infection is not associated with Repeat-Region polymorphism in the DC-SIGN neck domain and Novel Genetic DC-SIGN Variants among North Indians
has PubMed Central identifier	PMC7124224
has PubMed identifier	18255039
schema:publication	Clinica Chimica Acta
resource representing a document's body	covid:ff1dcf0a1deb1d323bd0b6a71f496d7a8a9c97f1#body_text
is schema:about of	named entity 'seropositive' named entity 'infection' named entity 'resistance' named entity 'allele' named entity 'HIV-1' named entity 'repeat' named entity 'DC-SIGN' named entity 'North Indians' covid:arg/ff1dcf0a1deb1d323bd0b6a71f496d7a8a9c97f1 named entity 'HSN' named entity 'respect' named entity 'North Indian' named entity 'study' named entity 'DC-SIGN' named entity 'neck' named entity 'control' named entity 'repeats' named entity 'Methods' named entity 'revealed' named entity 'HSN' named entity 'wild type' named entity 'intronic' named entity 'individual' named entity 'nucleotide' named entity 'polymorphism' named entity 'heterozygous' named entity 'homozygosity' named entity 'polymorphism' named entity 'intronic' named entity 'HSN' named entity 'HSN' named entity 'wild type' named entity 'randomly selected' named entity 'HIV-1' named entity 'seropositive' named entity 'North Indians' named entity 'genetic variants' named entity 'mutation' named entity 'HIV-1' named entity 'DC-SIGN' named entity 'North Indian' named entity 'HIV-1 infection' named entity 'alleles' named entity 'HIV-1' named entity 'CCR5' named entity 'genomic DNA' named entity 'denaturation' named entity 'Polymerase Chain Reaction' named entity 'sequenced' named entity 'genotype frequencies' named entity 'HSN' named entity 'blood sample' named entity 'allele' named entity 'HIV-1' named entity 'delta 32' named entity 'polymerase' named entity 'mutation' named entity 'ligand' named entity 'pneumonia' named entity 'restriction enzyme' named entity 'HIV-1' named entity 'polymorphism' named entity 'dNTPs' named entity 'seronegative' named entity 'allele' named entity 'Trojan horse' named entity 'DC-SIGN' named entity 'DC-SIGN' named entity 'HIV-1 infection' named entity 'CCR5' named entity 'mutants' named entity 'heterozygous' named entity 'Qiagen' named entity 'DC-SIGN' named entity 'tandem repeats'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software