About: RNA viruses in community-acquired childhood pneumonia in semi-urban Nepal; a cross-sectional study

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About: RNA viruses in community-acquired childhood pneumonia in semi-urban Nepal; a cross-sectional study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	RNA viruses in community-acquired childhood pneumonia in semi-urban Nepal; a cross-sectional study
Creator	Basnet, Sudha Hvidsten, Dag Mathisen, Maria Sommerfelt, Halvor Valentiner-Branth, Palle Adhikari, Ramesh Chandyo, Ram Sharma, Biswa Shrestha, Prakash Strand, Tor
source	Medline; PMC
abstract	BACKGROUND: Pneumonia is among the main causes of illness and death in children <5 years of age. There is a need to better describe the epidemiology of viral community-acquired pneumonia (CAP) in developing countries. METHODS: From July 2004 to June 2007, we examined nasopharyngeal aspirates (NPA) from 2,230 cases of pneumonia (World Health Organization criteria) in children 2 to 35 months old recruited in a randomized trial of zinc supplementation at a field clinic in Bhaktapur, Nepal. The specimens were examined for respiratory syncytial virus (RSV), influenza virus type A (InfA) and B (InfB), parainfluenza virus types 1, 2 and 3 (PIV1, PIV2, and PIV3), and human metapneumovirus (hMPV) using a multiplex reverse transcriptase polymerase chain reaction (PCR) assay. RESULTS: We identified 919 virus isolates in 887 (40.0%) of the 2,219 NPA specimens with a valid PCR result, of which 334 (15.1%) yielded RSV, 164 (7.4%) InfA, 129 (5.8%) PIV3, 98 (4.4%) PIV1, 93 (4.2%) hMPV, 84 (3.8%) InfB, and 17 (0.8%) PIV2. CAP occurred in an epidemic pattern with substantial temporal variation during the three years of study. The largest peaks of pneumonia occurrence coincided with peaks of RSV infection, which occurred in epidemics during the rainy season and in winter. The monthly number of RSV infections was positively correlated with relative humidity (r(s )= 0.40, P = 0.01), but not with temperature or rainfall. An hMPV epidemic occurred during one of the three winter seasons and the monthly number of hMPV cases was also associated with relative humidity (r(s )= 0.55, P = 0.0005). CONCLUSION: Respiratory RNA viruses were detected from NPA in 40% of CAP cases in our study. The most commonly isolated viruses were RSV, InfA, and PIV3. RSV infections contributed substantially to the observed CAP epidemics. The occurrence of viral CAP in this community seemed to reflect more or less overlapping micro-epidemics with several respiratory viruses, highlighting the challenges of developing and implementing effective public health control measures.
has issue date	2009-07-27(xsd:dateTime)
bibo:doi	10.1186/1741-7015-7-35
bibo:pmid	19635124
has license	cc-by
sha1sum (hex)	ff4fffe02138b0b232334d997965d11fd936916b
schema:url	https://doi.org/10.1186/1741-7015-7-35
resource representing a document's title	RNA viruses in community-acquired childhood pneumonia in semi-urban Nepal; a cross-sectional study
has PubMed Central identifier	PMC2727531
has PubMed identifier	19635124
schema:publication	BMC Med
resource representing a document's body	covid:ff4fffe02138b0b232334d997965d11fd936916b#body_text
is schema:about of	named entity 'age' named entity 'community-acquired pneumonia' named entity 'MEDICINE' named entity 'BMC' named entity 'URBAN' named entity 'COMMUNITY' named entity 'BACKGROUND' named entity 'DESCRIBE' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'CAUSES' named entity 'NEED' named entity 'DEATH' named entity 'AGE' named entity 'BETTER' named entity 'VIRAL' named entity 'NEPAL' named entity 'CROSS-SECTIONAL STUDY' named entity 'CHILDHOOD PNEUMONIA' named entity 'MAIN' named entity 'CHILDREN' named entity 'PNEUMONIA' named entity 'RNA VIRUSES' named entity 'ILLNESS' named entity 'DEVELOPING COUNTRIES' named entity 'ACQUIRED' named entity 'IS A' named entity 'YEARS' named entity 'EPIDEMIOLOGY' covid:arg/ff4fffe02138b0b232334d997965d11fd936916b named entity 'epidemiology' named entity 'viral' named entity 'developing countries' named entity 'Pneumonia' named entity 'BMC Medicine' named entity 'field clinic' named entity 'RSV infection' named entity 'Norway' named entity 'developing countries' named entity 'sensitivity and specificity' named entity 'vaccines' named entity 'PCR' named entity 'Bhaktapur district' named entity 'viral infections' named entity 'vomiting' named entity 'Streptococcus pneumoniae' named entity 'hMPV' named entity '10.0' named entity 'Nepal' named entity 'CAP' named entity 'influenza' named entity 'viruses' named entity 'pneumonia' named entity 'sub-tropical' named entity 'confidence intervals' named entity 'murine leukemia virus' named entity 'bocavirus' named entity 'pneumonia' named entity 'virus' named entity 'Severe malnutrition' named entity 'cDNA' named entity 'plasmid' named entity 'epidemic' named entity 'Korea' named entity 'dry ice' named entity 'daily values' named entity 'pneumonia' named entity 'viral culture' named entity 'pneumonia' named entity 'endemic' named entity 'LRTI' named entity 'internal control' named entity 'CAP'

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