About: Characterization of a recombinant canine coronavirus with a distinct receptor-binding (S1) domain

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of a recombinant canine coronavirus with a distinct receptor-binding (S1) domain
Creator	Millet, Jean Chillag, Zach Dubovi, Edward Licitra, Beth Regan, Andrew Tse, Whittaker, Gary Long, Ping Rinaldi, Vera Town, Christopher
Source	Elsevier; Medline; PMC
abstract	Abstract Canine alphacoronaviruses (CCoV) exist in two serotypes, type I and II, both of which can cause severe gastroenteritis. Here, we characterize a canine alphacoronavirus, designated CCoV-A76, first isolated in 1976. Serological studies show that CCoV-A76 is distinct from other CCoVs, such as the prototype CCoV-1-71. Efficient replication of CCoV-A76 is restricted to canine cell lines, in contrast to the prototypical type II strain CCoV-1-71 that more efficiently replicates in feline cells. CCoV-A76 can use canine aminopeptidase N (cAPN) receptor for infection of cells, but was unable to use feline APN (fAPN). In contrast, CCoV-1-71 can utilize both. Genomic analysis shows that CCoV-A76 possesses a distinct spike, which is the result of a recombination between type I and type II CCoV, that occurred between the N- and C-terminal domains (NTD and C-domain) of the S1 subunit. These data suggest that CCoV-A76 represents a recombinant coronavirus form, with distinct host cell tropism.
has issue date	2012-09-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2012.04.013
bibo:pmid	22609354
has license	els-covid
sha1sum (hex)	ff620d74cd09730846cb20cf1bb926ec58e41165
schema:url	https://doi.org/10.1016/j.virol.2012.04.013
resource representing a document's title	Characterization of a recombinant canine coronavirus with a distinct receptor-binding (S1) domain
has PubMed Central identifier	PMC3377836
has PubMed identifier	22609354
schema:publication	Virology
resource representing a document's body	covid:ff620d74cd09730846cb20cf1bb926ec58e41165#body_text
is schema:about of	named entity 'cell tropism' named entity 'cells' named entity 'aminopeptidase N' covid:arg/ff620d74cd09730846cb20cf1bb926ec58e41165 named entity 'alphacoronavirus' named entity 'data' named entity 'infection' named entity 'recombinant' named entity 'Canine' named entity 'infection' named entity 'Canine' named entity 'coronavirus' named entity 'cell tropism' named entity 'recombinant' named entity 'Canine' named entity 'recombinant' named entity 'lung' named entity 'Coronaviruses' named entity 'kidney' named entity 'glutamine' named entity 'virus' named entity 'anti-FLAG' named entity 'virus' named entity 'NTD' named entity 'nucleotide' named entity 'reverse transcribed' named entity 'infection' named entity 'Cornell University' named entity 'TACA' named entity 'fetal bovine serum' named entity 'FIPV' named entity 'RNA' named entity 'TGEV' named entity 'spike protein' named entity 'nucleotide' named entity 'GenBank' named entity 'molecular level' named entity 'TGEV' named entity 'Aminopeptidase' named entity 'cloned' named entity 'pathogenesis' named entity 'nucleocapsid' named entity 'amino acid sequences' named entity 'amino acid sequence' named entity 'ATCC' named entity 'Dye' named entity 'coronavirus' named entity 'receptor' named entity 'nucleocapsid' named entity 'open reading frame' named entity 'cell lines' named entity 'TGEV' named entity 'cell culture' named entity 'genotypes' named entity 'FCoV' named entity 'zoonotic' named entity 'Qiagen' named entity 'FCoV' named entity 'anti-FLAG' named entity 'nucleotide' named entity 'primer' named entity 'evolution' named entity 'breeding colony' named entity 'cell lines' named entity 'zoonotic' named entity 'Cornell University' named entity 'Neighbor-Joining method' named entity 'morbidity' named entity 'GenBank' named entity 'nucleotide' named entity 'N-terminal domain' named entity 'transfected'

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