About: Characterization of anti-viral immunity in recovered individuals infected by SARS-CoV-2

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About: Characterization of anti-viral immunity in recovered individuals infected by SARS-CoV-2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characterization of anti-viral immunity in recovered individuals infected by SARS-CoV-2
Creator	Zhao, Hui Li, Xiaoli Wang, Xinquan Deng, Yong-Qiang Qin, Cheng-Feng Wang, Pengzhi Feng, Yu Chen, Fang Ni, Ling Sun, Lin Dong, Chen Chen, Meng-Li Ge, Jiwan Guo, Han Liang, Peng Wei, Peng
source	MedRxiv
abstract	The WHO has declared SARS-CoV-2 outbreak a public health emergency of international concern. However, to date, there was hardly any study in characterizing the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. In this study, we collected blood from COVID-19 patients who have recently become virus-free and therefore were discharged, and analyzed their SARS-CoV-2-specific antibody and T cell responses. We observed SARS-CoV-2-specific humoral and cellular immunity in the patients. Both were detected in newly discharged patients, suggesting both participate in immune-mediated protection to viral infection. However, follow-up patients (2 weeks post discharge) exhibited high titers of IgG antibodies, but with low levels of virus-specific T cells, suggesting that they may enter a quiescent state. Our work has thus provided a basis for further analysis of protective immunity to SARS-CoV-2, and understanding the pathogenesis of COVID-19, especially in the severe cases. It has also implications in designing an effective vaccine to protect and treat SARS-CoV-2 infection.
has issue date	2020-03-20(xsd:dateTime)
bibo:doi	10.1101/2020.03.17.20036640
has license	medrxiv
sha1sum (hex)	ff9447fe8dd9a6747fea5d5b1a203f0be8fe3683
schema:url	https://doi.org/10.1101/2020.03.17.20036640
resource representing a document's title	Characterization of anti-viral immunity in recovered individuals infected by SARS-CoV-2
resource representing a document's body	covid:ff9447fe8dd9a6747fea5d5b1a203f0be8fe3683#body_text
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