About: Clinical Effects of Experimental Dual Infections with Porcine Reproductive and Respiratory Syndrome Virus Followed by Swine Influenza Virus in Conventional and Colostrum‐deprived Pigs

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About: Clinical Effects of Experimental Dual Infections with Porcine Reproductive and Respiratory Syndrome Virus Followed by Swine Influenza Virus in Conventional and Colostrum‐deprived Pigs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical Effects of Experimental Dual Infections with Porcine Reproductive and Respiratory Syndrome Virus Followed by Swine Influenza Virus in Conventional and Colostrum‐deprived Pigs
Creator	Nauwynck, H Pensaert, M Van Reeth, K
Source	Medline; PMC
abstract	Previous studies demonstrated that experimental dual infections of pigs with porcine reproductive and respiratory syndrome virus (PRRSV) followed by H1N1 influenza virus cause more severe disease and growth retardation than the respective single virus infections. Here three experiments were undertaken to better define the clinical impact of combined PRRSV‐H1N1 infections in conventional and caesarean‐derived colostrum‐deprived (CDCD) pigs. Groups of pigs were inoculated by aerosol with PRRSV followed by H1N1 at 3‐, 7‐ or 14‐day intervals. During the post‐H1N1 period, mean body temperatures, respiratory signs and mean weight gains in the PRRSV‐H1N1 inoculated groups were recorded and compared with those in uninoculated controls (experiments 1 and 2) or in singly virus‐inoculated pigs (experiment 3). In a first experiment with conventional pigs, the PRRSV‐3d‐H1N1 and PRRSV‐7d‐H1N1 infections induced mean body temperatures >40.5°C during 8 days (peaks 41.1 and 41.6°C, respectively) and mean growth reductions of 3.4 and 4.8 kg, respectively, during the 2 weeks after H1N1, along with marked depression and respiratory disease. The PRRSV‐14d‐H1N1 infection, on the contrary, was largely subclinical. In a second experiment with conventional pigs, PRRSV‐3d‐H1N1 and PRRSV‐7d‐H1N1 infections were clinically milder, with smaller increases in mean body temperatures (peak 40.5°C in both groups) and growth reductions (1.4 and 1.6 kg, respectively). In both groups, only one pig showed prominent general and respiratory signs. In a final experiment with CDCD pigs, PRRSV‐7d‐H1N1 infection had minimal effects on mean clinical performances and growth and, except for one pig that was severely affected, differences with the single virus inoculations were negligible. Thus, both the time interval between infections and the sanitary status of pigs can affect the clinical outcome of dual PRRSV‐H1N1 infections. However, factors so far unknown seem to cause large variations in the clinical response between individual pigs.
has issue date	2001-12-20(xsd:dateTime)
bibo:doi	10.1046/j.1439-0450.2001.00438.x
bibo:pmid	15129583
has license	no-cc
sha1sum (hex)	ffbc8ccb6863051aa3e8fb04ef5009878c87e7a1
schema:url	https://doi.org/10.1046/j.1439-0450.2001.00438.x
resource representing a document's title	Clinical Effects of Experimental Dual Infections with Porcine Reproductive and Respiratory Syndrome Virus Followed by Swine Influenza Virus in Conventional and Colostrum‐deprived Pigs
has PubMed Central identifier	PMC7165796
has PubMed identifier	15129583
schema:publication	J Vet Med B Infect Dis Vet Public Health
resource representing a document's body	covid:ffbc8ccb6863051aa3e8fb04ef5009878c87e7a1#body_text
is schema:about of	named entity 'infections' named entity 'infections' named entity 'disease' named entity 'respiratory' named entity 'conventional' named entity 'pigs' named entity 'intervals' named entity 'individual' named entity 'single' named entity 'Swine' named entity 'Experimental' named entity 'Pigs' named entity 'INCREASES' named entity 'VARIATIONS' named entity 'VIRUS' named entity 'LARGELY' named entity '3.4' covid:arg/ffbc8ccb6863051aa3e8fb04ef5009878c87e7a1 named entity 'Groups' named entity 'peaks' named entity '8 days' named entity 'growth retardation' named entity 'virus' named entity 'bacteria' named entity 'lungs' named entity 'inoculation' named entity 'H1N1' named entity 'respiratory' named entity 'H1N1' named entity 'reductions' named entity 'combined' named entity 'variations' named entity 'experiment' named entity 'day' named entity 'Porcine' named entity 'H1N1' named entity 'aerosol' named entity 'virus' named entity '8 days' named entity 'H1N1' named entity 'H1N1' named entity 'virus' named entity 'Virus' named entity 'reproductive' named entity 'Salmonella choleraesuis' named entity 'lungs' named entity 'M. hyopneumoniae' named entity 'viruses' named entity 'control group' named entity 'body temperature' named entity 'H1N1' named entity 'pig' named entity 'pig' named entity 'control group' named entity 'H1N1' named entity 'HEPA' named entity 'PRRSV' named entity 'H1N1' named entity 'infection' named entity 'H1N1' named entity 'H1N1 infection' named entity 'Van Reeth' named entity 'control group' named entity 'swine' named entity 'PRRSV' named entity 'fever' named entity 'H1N1' named entity 'PRRSV' named entity 'infection' named entity 'PRRSV' named entity 'H1N1' named entity 'Porcine reproductive and respiratory syndrome virus' named entity 'Virus transmission' named entity 'virus infection' named entity 'control group' named entity 'antibodies' named entity 'pneumonic' named entity 'upper respiratory tract' named entity 'body temperatures'

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