About: Effect of porcine circovirus type 2a or 2b on infection kinetics and pathogenicity of two genetically divergent strains of porcine reproductive and respiratory syndrome virus in the conventional pig model

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Effect of porcine circovirus type 2a or 2b on infection kinetics and pathogenicity of two genetically divergent strains of porcine reproductive and respiratory syndrome virus in the conventional pig model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effect of porcine circovirus type 2a or 2b on infection kinetics and pathogenicity of two genetically divergent strains of porcine reproductive and respiratory syndrome virus in the conventional pig model
Creator	Wang, Chong Gauger, Phillip Opriessnig, Tanja Meng, Xiang-Jin Shen, Huigang Halbur, Patrick Beach, Nathan Faaberg, Kay
Source	Elsevier; Medline; PMC
abstract	To determine differences in infection kinetics of two temporally and genetically different type 2 porcine reproductive and respiratory syndrome virus (PRRSV) isolates in vivo with and without concurrent porcine circovirus (PCV) type 2a or 2b infection, 62 pigs were randomly assigned to one of seven groups: negative controls (n = 8); pigs coinfected with a 1992 PRRSV strain (VR-2385) and PCV2a (CoI-92-2a; n = 9), pigs coinfected with VR-2385 and PCV2b (CoI-92-2b; n = 9), pigs coinfected with a 2006 PRRSV strain (NC16845b) and PCV2a (CoI-06-2a; n = 9), pigs coinfected with NC16845b and PCV2b (CoI-06-2b; n = 9), pigs infected with VR-2385 (n = 9), and pigs infected with NC16845b (n = 9). Blood samples were collected before inoculation and at day post-inoculation (dpi) 3, 6, 9 and 12 and tested for the presence of PRRSV antibody and RNA, PCV2 antibody and DNA, complete blood counts, and interferon gamma (IFN-γ) levels. Regardless of concurrent PCV2 infection, VR-2385 initially replicated at higher levels and reached peak replication levels at dpi 6. Pigs infected with VR-2385 had significantly higher amounts of viral RNA in serum on both dpi 3 and dpi 6, compared to pigs infected with NC16845b. The peak of NC16845b virus replication occurred between dpi 9 and dpi 12 and was associated with a delayed anti-PRRSV antibody response in these pigs. PCV2 coinfection resulted in significantly more severe macroscopic and microscopic lung lesions and a stronger anti-PRRSV IgG response compared to pigs infected with PRRSV alone. This work further emphasizes in vivo replication differences among PRRSV strains and the importance of coinfecting pathogens.
has issue date	2012-07-06(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2012.02.010
bibo:pmid	22406346
has license	no-cc
sha1sum (hex)	ffd2edf17cc705073a4b2c957ec16f55e745f67f
schema:url	https://doi.org/10.1016/j.vetmic.2012.02.010
resource representing a document's title	Effect of porcine circovirus type 2a or 2b on infection kinetics and pathogenicity of two genetically divergent strains of porcine reproductive and respiratory syndrome virus in the conventional pig model
has PubMed Central identifier	PMC7117418
has PubMed identifier	22406346
schema:publication	Vet Microbiol
resource representing a document's body	covid:ffd2edf17cc705073a4b2c957ec16f55e745f67f#body_text
is schema:about of	named entity 'EFFECT' named entity 'PATHOGENICITY' named entity 'KINETICS' named entity 'PORCINE CIRCOVIRUS TYPE 2A' named entity 'INFECTION' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'MODEL' named entity 'STRAINS' named entity 'CONVENTIONAL' named entity 'PIG' named entity 'strains' named entity 'type 2a' named entity 'porcine reproductive and respiratory syndrome virus' named entity 'serum' named entity 'PRRSV' named entity 'thymus' named entity 'p-value' named entity 'virulence' named entity 'hemagglutination inhibition' named entity '2.11' named entity 'PCV2' named entity 'PCV2' named entity 'coinfection' named entity 'primer' named entity 'synergistic' named entity 'real-time PCR' named entity 'synergistic interaction' named entity 'seroconversion' named entity 'genetically diverse' named entity 'clinical signs' named entity 'coughing' named entity 'primer' named entity 'homology' named entity 'coinfected' named entity 'standard curve' named entity 'WBC' named entity 'PCV2' named entity 'SIV' named entity 'viruses' named entity 'antigen' named entity 'antibodies' named entity 'WBC' named entity 'coinfected' named entity 'PRRSV' named entity 'Serum samples' named entity 'antibodies' named entity 'randomly assigned' named entity 'negative control' named entity 'PRRSV' named entity 'staining' named entity 'real-time PCR' named entity 'RNA' named entity 'Halbur' named entity 'antigen' named entity 'PCV2' named entity 'kidney' named entity 'PRRSV' named entity 'co-infection' named entity 'infection' named entity 'RNA' named entity 'PRRSV' named entity 'kidney' named entity '17.1' named entity 'type 2' named entity 'coinfected' named entity 'lymphoid tissues' named entity 'PRRSV' named entity 'real-time PCR' named entity 'immunohistochemistry' named entity 'Group 3' named entity 'virulence' named entity 'PRRSV' named entity 'Pharmaceutical' named entity 'porcine parvovirus'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software