About: establishing cell line

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Attributes	Values
type	Class
label	establishing cell line
subClassOf	establishing cell culture nodeID://b665191857 nodeID://b665216154 nodeID://b665814676 nodeID://b665838973 nodeID://b665871188 nodeID://b665895485 nodeID://b665919782 nodeID://b665944079
described by	proxy:entity/http/purl.obolibrary.org/obo/obi.owl
term editor	Person: Matthew Brush
definition	a process whereby a new type of cell line is created, either through passaging of a primary cell culture to relative genetic stability and compositional homogeneity, or through some experimental modification of an existing cell line to produce a new line with novel characteristics (e.g. immortalization or some other stable genetic modification, or selection of some defined subset).
definition source	PERSON:Matthew Brush
editor preferred term	establishing cell line
has curation status	metadata complete
editor note	2013-4-20 MHB: For cases of initial establilshment of a line from a primary culture, successive passaging and/or selection processes can confer increasing degrees of genetic stability and compositional homogeneity as compared to the input primary culture. Historically, many texts consider the first passage as the clearest point to define the beginning of a line. However, in practice it is more often that case that more than one passage, and possibly additional selective techniques, may be required before a culture is deemed to have sufficient stability and homogeneity to be considered cell line. This is the view taken in OBI. Regardless, what is important is that some intentional, experimental step has been taken to establish a more homogenous and stable culture that can be characterized and progatated over time.
is someValuesFrom of	nodeID://b665184199 nodeID://b665184201 nodeID://b665208496 nodeID://b665208498 nodeID://b665807018 nodeID://b665807020 nodeID://b665831315 nodeID://b665831317 nodeID://b665863530 nodeID://b665863532 nodeID://b665887827 nodeID://b665887829 nodeID://b665912124 nodeID://b665912126 nodeID://b665936421 nodeID://b665936423
is subClassOf of	cell line immortalization establishing cancer cell line
is topic of	Ontology for Biomedical Investigations

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