About: endocrine system

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An Entity of Type : owl:Class, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Class
label	endocrine system
subClassOf	anatomical system nodeID://b663515978 nodeID://b663516724 nodeID://b663520219 nodeID://b663520965 nodeID://b663913483 nodeID://b663914229 nodeID://b664388158 nodeID://b664388904 nodeID://b665079527 nodeID://b665080273 nodeID://b665130907 nodeID://b665131653 nodeID://b665420597 nodeID://b665421343 nodeID://b665796499 nodeID://b665797245 nodeID://b665797991 nodeID://b665798737 nodeID://b665799621 nodeID://b665800367 nodeID://b665805595 nodeID://b665806341 nodeID://b665860709 nodeID://b665861455 nodeID://b665862201 nodeID://b665862947 nodeID://b666208840 nodeID://b666209586 nodeID://b666238352 nodeID://b666239098
described by	https://covidontheweb.inria.fr:4443/about/id/entity/http/purl.obolibrary.org/obo/hso.owl proxy:entity/https/w3id.org/hso proxy:entity/http/purl.obolibrary.org/obo/hso.owl https://covidontheweb.inria.fr:4443/about/id/entity/https/w3id.org/hso
definition	Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity.
imported from	http://purl.obolibrary.org/obo/uberon.owl
database_cross_reference	wikipedia-en:Endocrine_system http://linkedlifedata.com/resource/umls/id/C0014136 http://www.snomedbrowser.com/Codes/Details/278876000 FBbt:00005068 AAO:0010279 CALOHA:TS-1301 EFO:0002969 EHDAA2:0002224 EMAPA:35306 EV:0100128 FMA:9668 GAID:439 MA:0000012 MESH:D004703 NCIT:C12705 TAO:0001158 UMLS:C0014136 VHOG:0000098 XAO:0000158 ZFA:0001158
has_exact_synonym	endocrine glandular system endocrine system systema endocrinum
in_subset	http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#efo_slim http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#pheno_slim http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#uberon_slim http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#vertebrate_core
has_obo_namespace	uberon
obo:id	UBERON:0000949
http://purl.obolib...bo/UBPROP_0000001	Anatomical system containing glands which regulates bodily functions though the secretion of hormones.[AAO]
http://purl.obolib...bo/UBPROP_0000003	Multicellular organisms have complex endocrine systems, allowing responses to environmental stimuli, regulation of development, reproduction, and homeostasis. Nuclear receptors (NRs), a metazoan-specific family of ligand-activated transcription factors, play central roles in endocrine responses, as intermediates between signaling molecules and target genes. The NR family includes ligand-bound and orphan receptors, that is, receptors with no known ligand or for which there is no ligand Pocket. Understanding NR evolution has been further improved by comparison of several completed genomes, particularly those of deuterostomes and ecdysozoans. In contrast, evolution of NR ligands is still much debated. One hypothesis proposes that several independent gains and losses of ligand-binding ability in NRs occurred in protostomes and deuterostomes. A second hypothesis, pertaining to the NR3 subfamily (vertebrate steroid hormone receptors and estrogen related receptor), proposes that before the divergence of protostomes and deuterostomes, there was an ancestral steroid receptor (AncSR) that was ligand-activated and that orphan receptors secondarily lost the ability to bind a ligand. (...) Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages (...).[well established][VHOG]
http://purl.obolib...bo/UBPROP_0000007	endocrine
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