About: uniprot:uniprot/#_AB37A1D72A6D288C_rdfs.comment

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About: uniprot:uniprot/#_AB37A1D72A6D288C_rdfs.comment_31AC0B4408C71405 Goto Sponge NotDistinct Permalink

An Entity of Type : rdf:Statement, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Statement
described by	proxy:entity/http/identifiers.org/uniprot/O35253 https://covidontheweb.inria.fr:4443/about/id/entity/http/purl.uniprot.org/uniprot/O35253
subject	uniprot:uniprot/O35253#SIP8AD4266D76B52590
predicate	comment
object	Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
uniprot:core/attribution	uniprot:uniprot/O35253#attribution-F8A62E4685392E55F5515349B78357FB
is topic of	uniprot:uniprot/O35253 http://identifiers.org/uniprot/O35253

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