Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, is a skin disease characterized by the sudden onset of fever, an elevated white blood cell count, and tender, red, well-demarcated papules and plaques that show dense infiltrates by neutrophil granulocytes on histologic examination. The syndrome was first described in 1964 by . It was also known as Gomm–Button disease in honour of the first two patients Sweet diagnosed with the condition.