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          "Valgansiklovir",
          "バルガンシクロビル",
          "Valganciclovir",
          "Valganciclovir",
          "Walgancyklowir",
          "Valganciclovir",
          "缬更昔洛韦",
          "Валганцикловір",
          "Valganciclovir",
          "فال قانسيكلوفير",
          "Valganciclovir" ] ,
        "http://www.w3.org/2000/01/rdf-schema#comment" : [ "Valganciclovir ist ein Virostatikum aus der Gruppe der Nucleosidanaloga. Es ist der L-Valinylester von Ganciclovir und fungiert als Resorptionsester: während Ganciclovir infudiert werden muss, wird Valganciclovir nach peroraler Verabreichung gut resorbiert und verfügt über eine hohe Bioverfügbarkeit. Nach Resorption wird Valganciclovir im Körper zu dem eigentlich wirksamen Ganciclovir umgewandelt. Valganciclovir wird als Hydrochlorid als Arzneistoff im Medikament Valcyte® (Roche) zur Behandlung der Cytomegalievirusretinitis bei Aids-Patienten verwendet.",
          "El valganciclovir es un antiviral utilizado para el tratamiento de las infecciones causadas por citomegalovirus, especialmente para las retinitis causadas por este tipo de virus en pacientes inmunodeprimidos como los enfermos de VIH/SIDA y las neumonías causadas por estos virus en pacientes que han recibido un trasplante. Es el éster conformado entre el ganciclovir y el aminoácido valina. \n* Datos: Q423384 \n* Multimedia: Valganciclovir / Q423384",
          "バルガンシクロビル（Valganciclovir）は、サイトメガロウイルスに対する抗ウイルス薬の一つである。ガンシクロビルをL-バリンでエステル化し、プロドラッグとしたものである。商品名バリキサ。",
          "Walgancyklowir (łac. valganciclovirum) – wielofunkcyjny organiczny związek chemiczny, ester L-walinowy gancyklowiru, stosowany jako prolek w zapobieganiu i leczeniu infekcji wirusem cytomegalii (CMV) u pacjentów z niedoborem odporności.",
          "Valganciclovir è una molecola ad attività antivirale. La molecola è un profarmaco di ganciclovir, ed è utilizzata per trattare o prevenire le infezioni da citomegalovirus con il blocco della sua replicazione mediante l'inibizione della sintesi del DNA virale. In Italia il farmaco è venduto dalla società farmaceutica Roche con il nome commerciale di Valcyte nella forma farmacologica di polvere per soluzione orale (una volta ricostituita la soluzione contiene 50 mg di valganciclovir per ogni ml).",
          "Valgansiklovir atau yang juga biasa dipasarkan dengan nama valcyte adalah obat antivirus yang digunakan dalam penanganan dan pencegahan penyakit yang disebabkan oleh sitomegalovirus pada pasien penderita AIDS atau penerima donor organ. Obat ini termasuk dalam salah satu Daftar Obat Esensial Organisasi Kesehatan Dunia.",
          "Валганциклові́р — синтетичний противірусний препарат з групи для перорального застосування. Валганцикловір розроблений швейцарською компанією «Hoffmann-La Roche», яка випускає його під торговельною назвою «Вальцит».",
          "فال قانسيكلوفير (بالإنجليزية: Valganciclovir)‏ هو دواء مضاد للفيروسات يستخدم لعلاج التهابات فيروس مضخم للخلايا (بالإنجليزية: CMV)‏.",
          "Le valganciclovir est un médicament antiviral agissant comme une prodrogue. Donné par voie orale, il est transformé en ganciclovir qui est la molécule active, ciblant le cytomégalovirus.",
          "纈更昔洛韋（英語：Valganciclovir），是一款抗病毒藥物，用以治療因愛滋病或器官移植造成巨細胞病毒感染，代表性的藥品品名為 Valcyte 。本品只能壓制感染，無法治癒，需長期使用。此藥是口服給藥。 常見的副作用為腹痛、頭痛、失眠、噁心、發燒及。其他的副作用有不孕及腎功能衰竭。有些動物在懷孕時使用此藥，造成了生育缺陷。本品是更昔洛韋的L-纈氨醯酯，到腸道及肝臟時會分解為更昔洛韋。 纈更昔洛韋在 2001 年通過醫療用途，列於世界衛生組織基本藥物標準清單，認可為醫療系統中安全有效的必需藥物。在開發中國家，每日藥費約在 30.16 至 52.14 美元之間。2016年時，在美國，平均每日批發價為 58.54 美元。2017年，其通用名藥物通過核可[6]。",
          "Valganciclovir é um pró-fármaco utilizado pela medicina como antiviral, no tratamento e profilaxia da retinite por citomegalovírus em portadores do vírus HIV.",
          "Valganciclovir, sold under the brand name Valcyte among others, is an antiviral medication used to treat cytomegalovirus (CMV) infection in those with HIV/AIDS or following organ transplant. It is often used long term as it only suppresses rather than cures the infection. Valganciclovir is taken by mouth. Valganciclovir was approved for medical use in 2001. It is on the World Health Organization's List of Essential Medicines. In 2017, a generic version was approved." ] ,
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        "http://dbpedia.org/ontology/abstract" : [ "فال قانسيكلوفير (بالإنجليزية: Valganciclovir)‏ هو دواء مضاد للفيروسات يستخدم لعلاج التهابات فيروس مضخم للخلايا (بالإنجليزية: CMV)‏.",
          "Walgancyklowir (łac. valganciclovirum) – wielofunkcyjny organiczny związek chemiczny, ester L-walinowy gancyklowiru, stosowany jako prolek w zapobieganiu i leczeniu infekcji wirusem cytomegalii (CMV) u pacjentów z niedoborem odporności.",
          "Valgansiklovir atau yang juga biasa dipasarkan dengan nama valcyte adalah obat antivirus yang digunakan dalam penanganan dan pencegahan penyakit yang disebabkan oleh sitomegalovirus pada pasien penderita AIDS atau penerima donor organ. Obat ini termasuk dalam salah satu Daftar Obat Esensial Organisasi Kesehatan Dunia.",
          "バルガンシクロビル（Valganciclovir）は、サイトメガロウイルスに対する抗ウイルス薬の一つである。ガンシクロビルをL-バリンでエステル化し、プロドラッグとしたものである。商品名バリキサ。",
          "Valganciclovir, sold under the brand name Valcyte among others, is an antiviral medication used to treat cytomegalovirus (CMV) infection in those with HIV/AIDS or following organ transplant. It is often used long term as it only suppresses rather than cures the infection. Valganciclovir is taken by mouth. Common side effects include abdominal pain, headaches, trouble sleeping, nausea, fever, and low blood cell counts. Other side effects may include infertility and kidney problems. When used during pregnancy, it causes birth defects in some animals. Valganciclovir is the L-valyl ester of ganciclovir and works when broken down into ganciclovir by the intestine and liver. Valganciclovir was approved for medical use in 2001. It is on the World Health Organization's List of Essential Medicines. In 2017, a generic version was approved.",
          "Валганциклові́р — синтетичний противірусний препарат з групи для перорального застосування. Валганцикловір розроблений швейцарською компанією «Hoffmann-La Roche», яка випускає його під торговельною назвою «Вальцит».",
          "纈更昔洛韋（英語：Valganciclovir），是一款抗病毒藥物，用以治療因愛滋病或器官移植造成巨細胞病毒感染，代表性的藥品品名為 Valcyte 。本品只能壓制感染，無法治癒，需長期使用。此藥是口服給藥。 常見的副作用為腹痛、頭痛、失眠、噁心、發燒及。其他的副作用有不孕及腎功能衰竭。有些動物在懷孕時使用此藥，造成了生育缺陷。本品是更昔洛韋的L-纈氨醯酯，到腸道及肝臟時會分解為更昔洛韋。 纈更昔洛韋在 2001 年通過醫療用途，列於世界衛生組織基本藥物標準清單，認可為醫療系統中安全有效的必需藥物。在開發中國家，每日藥費約在 30.16 至 52.14 美元之間。2016年時，在美國，平均每日批發價為 58.54 美元。2017年，其通用名藥物通過核可[6]。",
          "Valganciclovir è una molecola ad attività antivirale. La molecola è un profarmaco di ganciclovir, ed è utilizzata per trattare o prevenire le infezioni da citomegalovirus con il blocco della sua replicazione mediante l'inibizione della sintesi del DNA virale. In Italia il farmaco è venduto dalla società farmaceutica Roche con il nome commerciale di Valcyte nella forma farmacologica di polvere per soluzione orale (una volta ricostituita la soluzione contiene 50 mg di valganciclovir per ogni ml).",
          "Le valganciclovir est un médicament antiviral agissant comme une prodrogue. Donné par voie orale, il est transformé en ganciclovir qui est la molécule active, ciblant le cytomégalovirus.",
          "El valganciclovir es un antiviral utilizado para el tratamiento de las infecciones causadas por citomegalovirus, especialmente para las retinitis causadas por este tipo de virus en pacientes inmunodeprimidos como los enfermos de VIH/SIDA y las neumonías causadas por estos virus en pacientes que han recibido un trasplante. Es el éster conformado entre el ganciclovir y el aminoácido valina. Su modo de acción es el mismo que el del ganciclovir. La diferencia radica en su vía de administración que es oral, lo cual permite que sea fácilmente transformada en ganciclovir por acción de las enzimas hepáticas e intestinales llamadas esterasas; además, su biodisponibilidad es mucho mayor que la del ganciclovir. Los efectos adversos que presenta son granulocitopenia, trombocitopenia, neutropenia, anemia, fiebre, náuseas, vómito, dispepsia, diarrea, anorexia, pero la mielosupresión es la más destacable. Recientemente, la Universidad de Stanford en California ha desarrollado un estudio que propone al valganciclovir como medicamento eficaz contra el síndrome de fatiga crónica. Estos estudios se están realizando desde inicios de 2007. \n* Datos: Q423384 \n* Multimedia: Valganciclovir / Q423384",
          "Valganciclovir ist ein Virostatikum aus der Gruppe der Nucleosidanaloga. Es ist der L-Valinylester von Ganciclovir und fungiert als Resorptionsester: während Ganciclovir infudiert werden muss, wird Valganciclovir nach peroraler Verabreichung gut resorbiert und verfügt über eine hohe Bioverfügbarkeit. Nach Resorption wird Valganciclovir im Körper zu dem eigentlich wirksamen Ganciclovir umgewandelt. Valganciclovir wird als Hydrochlorid als Arzneistoff im Medikament Valcyte® (Roche) zur Behandlung der Cytomegalievirusretinitis bei Aids-Patienten verwendet. Valganciclovir weist als Prodrug des Ganciclovir die gleichen Wirkungen und Nebenwirkungen wie dieses auf. Es sind dies z. T. lebensbedrohliche Störungen. Es wird über Neutropenie bis hin zur Agranulozytose, Anämie, Thrombozytopenie, Durchfall, Erbrechen, Bauchschmerzen, Kopfschmerz, Neuropathien und Leberzellschäden im Zusammenhang mit der Einnahme von Valganciclovir berichtet. Es soll daher nur bei lebens- oder augenlichtbedrohenden Infektionen angewendet werden.",
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