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Subject Item

dbr:HBx

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yago:PhysicalEntity100001930 owl:Thing wd:Q206229 dbo:Biomolecule yago:Relation100031921 yago:Part113809207 wd:Q8054 dbr:Protein yago:WikicatViralProteins dbo:Protein yago:Matter100020827 yago:Molecule114682133 yago:Macromolecule114944888 yago:Material114580897 yago:Chemical114806838 yago:Compound114818238 yago:Unit109465459 yago:Substance100019613 yago:Thing100002452 yago:OrganicCompound114727670 yago:Protein114728724 yago:Abstraction100002137

rdfs:label

HBx HBx

rdfs:comment

HBx is a hepatitis B viral protein. It is 154 amino acids long and interferes with transcription, signal transduction, cell cycle progress, protein degradation, apoptosis and chromosomal stability in the host. It forms a heterodimeric complex with its cellular target protein (HBX interacting protein: HBXIP), and this interaction dysregulates centrosome dynamics and mitotic spindle formation. It interacts with DDB1 (Damaged DNA Binding Protein 1) redirecting the ubiquitin ligase activity of the -DDB1 E3 complexes, which are intimately involved in the intracellular regulation of DNA replication and repair, transcription and signal transduction. HBx adakah protein virus hepatitis B. Protein ini memiliki panjang 154 asam amino dan mengganggu transkripsi, transduksi sinyal, perkembangan siklus sel, degradasi protein, apoptosis, dan stabilitas kromosom pada sel inang. Protein ini membentuk kompleks heterodimer dengan protein target selulernya (protein yang berinteraksi dengan HBX: ), dan interaksi ini mendisregulasi dinamika sentrosom dan pembentukan pemintal kromosom. Protein ini berinteraksi dengan (Protein Pengikatan DNA Rusak 1), mengalihkan aktivitas dari kompleks -DDB1 yang secara detail melibatkan regulasi replikasi dan perbaikan DNA intraseluler, , dan transduksi sinyal.

owl:sameAs

yago-res:HBx dbpedia-id:HBx n16:4kHvt n21:05b0dj2 wd:Q5629069 dbr:HBx

dbp:name

Transactivation protein X Protein X

foaf:topic

dbr:Hepatitis_B_virus n17: wikipedia-en:HBx n23: dbr:Debi_Prasad_Sarkar n31:this dbr:IRS1

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n28:svg

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n4:DNA n14:Part113809207 n4:Amino_acid n4:Telomerase n14:Protein114728724 n4:Gene_expression n22:Protein n14:Chemical114806838 n25: n4:Ubiquitin_ligase n14:Compound114818238 n4:Reactive_oxygen_species n14:OrganicCompound114727670 n22:Amino_acid n14:Unit109465459 n4:Methyltransferase n22:Cell_cycle

dct:subject

dbc:Viral_proteins dbc:Hepatitis_B_virus dbc:Viral_nonstructural_proteins

dbo:wikiPageID

20938446

dbo:wikiPageRevisionID

1098109377

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dbr:DNA_glycosylase dbr:Reactive_oxygen_species dbr:Sirtuin_1 dbr:HBcAg dbr:Hepatitis_B dbr:Methyltransferase dbr:Exon dbr:Mitotic_spindle dbr:Telomerase_reverse_transcriptase dbr:Ubiquitin_ligase dbr:HBsAg dbr:DNA dbc:Hepatitis_B_virus dbr:Cancer_epigenetics dbr:DNA_methylation dbc:Viral_nonstructural_proteins dbr:Gene_expression n30: dbr:Intracellular dbr:Endoplasmic_reticulum dbr:Cell_cycle dbr:Long_non-coding_RNA dbr:P300-CBP_coactivator_family dbr:CpG_site dbr:Viral_protein dbr:Apoptosis dbr:HDAC1 dbr:Centrosome dbr:CUL4 n32:svg dbr:Methylation dbr:Telomerase dbr:MicroRNA dbr:Regulation_of_transcription_in_cancer dbr:Avihepadnavirus dbr:DDB1 dbr:CccDNA dbr:HBXIP dbr:Amino_acid dbr:PRMT1

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wikipedia-en:HBx

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n18:hypernym

dbr:Protein

dbo:abstract

HBx is a hepatitis B viral protein. It is 154 amino acids long and interferes with transcription, signal transduction, cell cycle progress, protein degradation, apoptosis and chromosomal stability in the host. It forms a heterodimeric complex with its cellular target protein (HBX interacting protein: HBXIP), and this interaction dysregulates centrosome dynamics and mitotic spindle formation. It interacts with DDB1 (Damaged DNA Binding Protein 1) redirecting the ubiquitin ligase activity of the -DDB1 E3 complexes, which are intimately involved in the intracellular regulation of DNA replication and repair, transcription and signal transduction. Although Protein X is normally absent in the Avihepadnavirus, a vestigial version has been identified in the duck hepatitis virus genome. Although it lacks significant sequence identity with any known vertebrate proteins, it seems likely that it evolved from a DNA glycosylase. Transgenic mice expressing the X protein in liver are more likely than the wild type to develop hepatocellular carcinoma. This is because the X protein promotes cell cycle progression while binding to and inhibiting tumor suppressor protein p53 from performing their role. Experimental observations also suggest that HBx protein increases TERT and telomerase activity, prolonging the lifespan of hepatocytes and contributing to malignant transformation. HBx adakah protein virus hepatitis B. Protein ini memiliki panjang 154 asam amino dan mengganggu transkripsi, transduksi sinyal, perkembangan siklus sel, degradasi protein, apoptosis, dan stabilitas kromosom pada sel inang. Protein ini membentuk kompleks heterodimer dengan protein target selulernya (protein yang berinteraksi dengan HBX: ), dan interaksi ini mendisregulasi dinamika sentrosom dan pembentukan pemintal kromosom. Protein ini berinteraksi dengan (Protein Pengikatan DNA Rusak 1), mengalihkan aktivitas dari kompleks -DDB1 yang secara detail melibatkan regulasi replikasi dan perbaikan DNA intraseluler, , dan transduksi sinyal. Walaupun Protein X umumnya tidak terdapat pada , versi vestigial telah teridentifikasi pada genom virus hepatitis bebek. Walaupun protein ini tidak memiliki identitas sekuens yang signifikan dengan semua protein vertebrata yang diketahui, protein ini sepertinya berevolusi dari . Mencit transgenik mengekspresikan protein X di hati lebih mungkin terjadi dibandingkan dengan karsinoma hepatoseluler yang timbul pada tipe liar. Hal ini terjadi karena protein X mendorong perkembangan siklus sel sambil berikatan dan menghambat protein supresor tumor p53 melakukan perannya. Observasi eksperimen juga mengacu bahwa protein HBx meningkatkan aktivitas dan telomerase, memperpanjang masa hidup hepatosit dan berkontribusi pada transformasi berbahaya.

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n29:300

dbp:symbol

X

dbp:uniprot

P0C685

dbp:organism

Hepatitis B virus genotype B2

dbp:interpro

IPR000236

dbp:pfam

PF00739

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13767

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dbt:Reflist dbt:Pfam_box dbt:Other_uses dbt:Infobox_nonhuman_protein dbt:Viral_proteins