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dbr:Metapristone
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dbo:ChemicalSubstance dbo:Drug wd:Q8386 n24:ChemicalObject owl:Thing
rdfs:label
Metapristone
rdfs:comment
Metapristone (developmental code name RU-42633; also known as desmethylmifepristone) is the major metabolite of mifepristone (RU-486, RU-38486) and a selective progesterone receptor modulator (SPRM) which itself was never marketed. It is formed from mifepristone in the liver by the enzyme CYP3A4 via monodemethylation, and circulates at concentrations higher than those of mifepristone. The metabolite retains partial but considerable affinity for the progesterone receptor (PR) and the glucocorticoid receptor (GR) (RBA = 21% and 61% of that of mifepristone for the human forms of these receptors, respectively). On the basis of actions that are apparently independent of its hormonal activity, metapristone is being researched as a potential cancer metastatic chemopreventive agent.
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dbr:Desmethylmifepristone dbr:C28H33NO2 dbr:N-Desmethylmifepristone dbr:RU42633 n16:633 dbr:RU-42633 dbr:N-Demethylmifepristone dbr:Monodesmethylmifepristone dbr:R42633 dbr:Monodemethylmifepristone dbr:R_42633 n22:this dbr:Demethylmifepristone n23:633 wikipedia-en:Metapristone dbr:Mifepristone dbr:RU_42633 n25:633 dbr:N-desmethylmifepristone n27:633 dbr:R-42633 dbr:N-demethylmifepristone
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dbo:abstract
Metapristone (developmental code name RU-42633; also known as desmethylmifepristone) is the major metabolite of mifepristone (RU-486, RU-38486) and a selective progesterone receptor modulator (SPRM) which itself was never marketed. It is formed from mifepristone in the liver by the enzyme CYP3A4 via monodemethylation, and circulates at concentrations higher than those of mifepristone. The metabolite retains partial but considerable affinity for the progesterone receptor (PR) and the glucocorticoid receptor (GR) (RBA = 21% and 61% of that of mifepristone for the human forms of these receptors, respectively). On the basis of actions that are apparently independent of its hormonal activity, metapristone is being researched as a potential cancer metastatic chemopreventive agent.
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RU-42633; Desmethylmifepristone; 17β-Hydroxy-11β-[4-phenyl]-17α-estra-4,9-dien-3-one
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K1P8OGJ86J
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