. . . . . . . . . . . . "1101890618"^^ . . . . "ErbB-3 (HER3) \u2014 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u043D\u044B\u0439 \u0431\u0435\u043B\u043E\u043A, \u0432\u0445\u043E\u0434\u0438\u0442 \u0432 \u0441\u0435\u043C\u0435\u0439\u0441\u0442\u0432\u043E \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440\u0430 \u044D\u043F\u0438\u0434\u0435\u0440\u043C\u0430\u043B\u044C\u043D\u043E\u0433\u043E \u0444\u0430\u043A\u0442\u043E\u0440\u0430 \u0440\u043E\u0441\u0442\u0430 EGFR/ErbB \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440\u043D\u044B\u0445 \u0442\u0438\u0440\u043E\u0437\u0438\u043D\u043E\u0432\u044B\u0445 \u043F\u0440\u043E\u0442\u0435\u0438\u043D\u043A\u0438\u043D\u0430\u0437, \u043A\u043E\u0434\u0438\u0440\u0443\u0435\u0442\u0441\u044F \u0433\u0435\u043D\u043E\u043C \u0447\u0435\u043B\u043E\u0432\u0435\u043A\u0430 ERBB3."@ru . . . . . "ERBB3"@es . . . . . . . . . . . . . "La tirosina prote\u00EDna quinasa receptora ERBB3 es una enzima que en los humanos es codificada por el gen HGNC ERBB3 . Este gen codifica un miembro de la familia de los receptores de factores de crecimiento epid\u00E9rmico (EGFR). Esta prote\u00EDna unida a membrana tiene un dominio de uni\u00F3n a la neuregulina pero no tiene un dominio quinasa activo. Por tanto, puede unir su ligando pero no transmite la se\u00F1al a la c\u00E9lula a trav\u00E9s de la fosforilaci\u00F3n de prote\u00EDnas. De todas formas, esta enzima forma heterod\u00EDmeros con otros miembros de la familia EGFR que tienen actividad quinasa. La heterodimerizaci\u00F3n provoca la activaci\u00F3n de rutas que producen proliferaci\u00F3n celular y diferenciaci\u00F3n. La amplificaci\u00F3n de este gen y/o la sobrexpresi\u00F3n de su prote\u00EDna ha sido reportada en numerosos c\u00E1nceres, incluyendo los de "@es . "La tirosina prote\u00EDna quinasa receptora ERBB3 es una enzima que en los humanos es codificada por el gen HGNC ERBB3 . Este gen codifica un miembro de la familia de los receptores de factores de crecimiento epid\u00E9rmico (EGFR). Esta prote\u00EDna unida a membrana tiene un dominio de uni\u00F3n a la neuregulina pero no tiene un dominio quinasa activo. Por tanto, puede unir su ligando pero no transmite la se\u00F1al a la c\u00E9lula a trav\u00E9s de la fosforilaci\u00F3n de prote\u00EDnas. De todas formas, esta enzima forma heterod\u00EDmeros con otros miembros de la familia EGFR que tienen actividad quinasa. La heterodimerizaci\u00F3n provoca la activaci\u00F3n de rutas que producen proliferaci\u00F3n celular y diferenciaci\u00F3n. La amplificaci\u00F3n de este gen y/o la sobrexpresi\u00F3n de su prote\u00EDna ha sido reportada en numerosos c\u00E1nceres, incluyendo los de pr\u00F3stata, vejiga urinaria y mama. Se han caracterizado diferentes isoformas formadas por splicing alternativo. Una isoforma no tiene la regi\u00F3n intermembrana y es secretada al exterior de la c\u00E9lula. Esta forma act\u00FAa modulando la actividad de la forma unida a la membrana. Otras variantes por splicing alternativo han sido reportadas pero no han sido caracterizadas.\u200B Se cree que la ERBB3 activada se convierte en sustrato para dimerizaci\u00F3n y fosforilaci\u00F3n de , ERBB2 y ERBB4. Como otras tirosina prote\u00EDna quinasas receptoras, la ERBB3 es activada por un ligando extracelular. Un ligando conocido por activar la ERBB3 es la heregulina. Los defectos en ERBB3 son causa del s\u00EDndrome tipo 2 de contractura cong\u00E9nita letal (LCCS2). Es una forma neurog\u00E9nica recesiva autosomal de artrogriposis neonatal letal que se asocia con atrofia del cornu anterius de la m\u00E9dula espinal. El LCCS2 est\u00E1 caracterizado por contracturas en las articulaciones y la presencia de una vejiga urinaria dilatada. El fenotipo sugiere una etiolog\u00EDa neurop\u00E1tica de la m\u00E9dula espinal.\u200B"@es . . . . . . . . . "Il recettore tirosin chinasico erbB-3 \u00E8 un enzima che nell'uomo viene codificato dal gene ERBB3. Struttura proteica codificata da ERBB3Pattern di espressione ad RNA del gene ERBB3 Questo gene codifica per una porzione del recettore del fattore di crescita dell'epidermide (Epidermal Growth Factor Receptor, EGFR) appartenente alla famiglia dei recettori tirosin chinasici. Questa proteina di membrana possiede neurodominio di interazione, ma non un dominio di attivazione chinasi dipendente. Risulta quindi possibile l'associazione con un ligando, ma non la trasmissione del segnale all'interno della cellula attraverso le reazioni di fosforilazione delle proteine segnale. Tuttavia, erbB-3 risulta in grado di costituire eterodimeri associandosi ad altri membri della famiglia del recettore EGF i quali possiedono domini di attivazione chinasi dipendente. L'eterodimerizzazione consente l'attivazione di reazioni a cascata all'interno della cellula che portano alla proliferazione cellulare o alla differenziazione. L'eventuale amplificazione del gene ERBB3 o la sua sovraespressione, portano all'accumulo della proteina erbB-3, tale accumulo di prodotto proteico \u00E8 stato riscontrato in numerosi tumori, tra cui quello alla prostata, alla vescica e nei tumori al seno. L'RNA del gene pu\u00F2 essere sottoposto a splicing alternativo, ci\u00F2 consente la codifica di diverse varianti, le quali una volta tradotte danno origine a diverse isoforme proteiche. Una particolare isoforma \u00E8 priva della regione intermembranale e viene quindi secreta all'esterno della cellula; Tale isoforma consente la modulazione dell'attivit\u00E0 dell'isoforma legata alla membrana. Altre varianti di splicing sono state identificate, ma non sono state completamente caratterizzate. Si ritiene che ERBB3, se attivato, diventi un substrato per la dimerizzazione e fosforilazione successiva di: ErbB1, ErbB2 e ERBB4. Come molti dei recettori tirosin chinasici, ERBB3 \u00E8 attivato dal ligando extracellulare. Ligandi noti in grado di legarsi a ERBB3 sono le Neuregulin."@it . "ERBB3"@en . . . "Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene. ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ErbB3 is known to form active heterodimers with other members of the ErbB family, most notably the ligand binding-impaired ErbB2."@en . . . . . . . . . . . . . . . . . . . . . . . . "22524"^^ . . . . . "ErbB-3 (HER3) \u2014 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u043D\u044B\u0439 \u0431\u0435\u043B\u043E\u043A, \u0432\u0445\u043E\u0434\u0438\u0442 \u0432 \u0441\u0435\u043C\u0435\u0439\u0441\u0442\u0432\u043E \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440\u0430 \u044D\u043F\u0438\u0434\u0435\u0440\u043C\u0430\u043B\u044C\u043D\u043E\u0433\u043E \u0444\u0430\u043A\u0442\u043E\u0440\u0430 \u0440\u043E\u0441\u0442\u0430 EGFR/ErbB \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440\u043D\u044B\u0445 \u0442\u0438\u0440\u043E\u0437\u0438\u043D\u043E\u0432\u044B\u0445 \u043F\u0440\u043E\u0442\u0435\u0438\u043D\u043A\u0438\u043D\u0430\u0437, \u043A\u043E\u0434\u0438\u0440\u0443\u0435\u0442\u0441\u044F \u0433\u0435\u043D\u043E\u043C \u0447\u0435\u043B\u043E\u0432\u0435\u043A\u0430 ERBB3."@ru . . . . . . . . "14111610"^^ . . . . . . . "ERBB3"@uk . . . . . . "ERBB3 (\u0430\u043D\u0433\u043B. Erb-b2 receptor tyrosine kinase 3) \u2013 \u0431\u0456\u043B\u043E\u043A, \u044F\u043A\u0438\u0439 \u043A\u043E\u0434\u0443\u0454\u0442\u044C\u0441\u044F \u043E\u0434\u043D\u043E\u0439\u043C\u0435\u043D\u043D\u0438\u043C \u0433\u0435\u043D\u043E\u043C, \u0440\u043E\u0437\u0442\u0430\u0448\u043E\u0432\u0430\u043D\u0438\u043C \u0443 \u043B\u044E\u0434\u0435\u0439 \u043D\u0430 \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u043C\u0443 \u043F\u043B\u0435\u0447\u0456 12-\u0457 \u0445\u0440\u043E\u043C\u043E\u0441\u043E\u043C\u0438. \u0414\u043E\u0432\u0436\u0438\u043D\u0430 \u043F\u043E\u043B\u0456\u043F\u0435\u043F\u0442\u0438\u0434\u043D\u043E\u0433\u043E \u043B\u0430\u043D\u0446\u044E\u0433\u0430 \u0431\u0456\u043B\u043A\u0430 \u0441\u0442\u0430\u043D\u043E\u0432\u0438\u0442\u044C 1 342 \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442, \u0430 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044F\u0440\u043D\u0430 \u043C\u0430\u0441\u0430 \u2014 148 098. \u041F\u043E\u0441\u043B\u0456\u0434\u043E\u0432\u043D\u0456\u0441\u0442\u044C \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442 A: \u0410\u043B\u0430\u043D\u0456\u043DC: \u0426\u0438\u0441\u0442\u0435\u0457\u043DD: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430E: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430F: \u0424\u0435\u043D\u0456\u043B\u0430\u043B\u0430\u043D\u0456\u043DG: \u0413\u043B\u0456\u0446\u0438\u043DH: \u0413\u0456\u0441\u0442\u0438\u0434\u0438\u043DI: \u0406\u0437\u043E\u043B\u0435\u0439\u0446\u0438\u043DK: \u041B\u0456\u0437\u0438\u043DL: \u041B\u0435\u0439\u0446\u0438\u043DM: \u041C\u0435\u0442\u0456\u043E\u043D\u0456\u043DN: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043DP: \u041F\u0440\u043E\u043B\u0456\u043DQ: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043DR: \u0410\u0440\u0433\u0456\u043D\u0456\u043DS: \u0421\u0435\u0440\u0438\u043DT: \u0422\u0440\u0435\u043E\u043D\u0456\u043DV: \u0412\u0430\u043B\u0456\u043DW: \u0422\u0440\u0438\u043F\u0442\u043E\u0444\u0430\u043D Y: \u0422\u0438\u0440\u043E\u0437\u0438\u043D \u041A\u043E\u0434\u043E\u0432\u0430\u043D\u0438\u0439 \u0433\u0435\u043D\u043E\u043C \u0431\u0456\u043B\u043E\u043A \u0437\u0430 \u0444\u0443\u043D\u043A\u0446\u0456\u044F\u043C\u0438 \u043D\u0430\u043B\u0435\u0436\u0438\u0442\u044C \u0434\u043E \u0442\u0440\u0430\u043D\u0441\u0444\u0435\u0440\u0430\u0437, \u043A\u0456\u043D\u0430\u0437, \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440\u0456\u0432, \u0442\u0438\u0440\u043E\u0437\u0438\u043D\u043E\u0432\u0438\u0445 \u043F\u0440\u043E\u0442\u0435\u0457\u043D\u043A\u0456\u043D\u0430\u0437, \u0444\u043E\u0441\u0444\u043E\u043F\u0440\u043E\u0442\u0435\u0457\u043D\u0456\u0432. \u0417\u0430\u0434\u0456\u044F\u043D\u0438\u0439 \u0443 \u0442\u0430\u043A\u043E\u043C\u0443 \u0431\u0456\u043E\u043B\u043E\u0433\u0456\u0447\u043D\u043E\u043C\u0443 \u043F\u0440\u043E\u0446\u0435\u0441\u0456, \u044F\u043A \u0430\u043B\u044C\u0442\u0435\u0440\u043D\u0430\u0442\u0438\u0432\u043D\u0438\u0439 \u0441\u043F\u043B\u0430\u0439\u0441\u0438\u043D\u0433. \u0411\u0456\u043B\u043E\u043A \u043C\u0430\u0454 \u0441\u0430\u0439\u0442 \u0434\u043B\u044F \u0437\u0432'\u044F\u0437\u0443\u0432\u0430\u043D\u043D\u044F \u0437 \u0410\u0422\u0424, \u043D\u0443\u043A\u043B\u0435\u043E\u0442\u0438\u0434\u0430\u043C\u0438. \u041B\u043E\u043A\u0430\u043B\u0456\u0437\u043E\u0432\u0430\u043D\u0438\u0439 \u0443 \u043A\u043B\u0456\u0442\u0438\u043D\u043D\u0456\u0439 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u0456, \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u0456.\u0422\u0430\u043A\u043E\u0436 \u0441\u0435\u043A\u0440\u0435\u0442\u043E\u0432\u0430\u043D\u0438\u0439 \u043D\u0430\u0437\u043E\u0432\u043D\u0456."@uk . . . . . "Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene. ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ErbB3 is known to form active heterodimers with other members of the ErbB family, most notably the ligand binding-impaired ErbB2."@en . . . . . . "Il recettore tirosin chinasico erbB-3 \u00E8 un enzima che nell'uomo viene codificato dal gene ERBB3. Struttura proteica codificata da ERBB3Pattern di espressione ad RNA del gene ERBB3 Questo gene codifica per una porzione del recettore del fattore di crescita dell'epidermide (Epidermal Growth Factor Receptor, EGFR) appartenente alla famiglia dei recettori tirosin chinasici. Questa proteina di membrana possiede neurodominio di interazione, ma non un dominio di attivazione chinasi dipendente. Risulta quindi possibile l'associazione con un ligando, ma non la trasmissione del segnale all'interno della cellula attraverso le reazioni di fosforilazione delle proteine segnale. Tuttavia, erbB-3 risulta in grado di costituire eterodimeri associandosi ad altri membri della famiglia del recettore EGF i qu"@it . . . . . . "ERBB3"@it . . . . . . . . . . . . . . "ErbB3"@ru . . . . . . . . . . . . . . . . . . . . "ERBB3 (\u0430\u043D\u0433\u043B. Erb-b2 receptor tyrosine kinase 3) \u2013 \u0431\u0456\u043B\u043E\u043A, \u044F\u043A\u0438\u0439 \u043A\u043E\u0434\u0443\u0454\u0442\u044C\u0441\u044F \u043E\u0434\u043D\u043E\u0439\u043C\u0435\u043D\u043D\u0438\u043C \u0433\u0435\u043D\u043E\u043C, \u0440\u043E\u0437\u0442\u0430\u0448\u043E\u0432\u0430\u043D\u0438\u043C \u0443 \u043B\u044E\u0434\u0435\u0439 \u043D\u0430 \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u043C\u0443 \u043F\u043B\u0435\u0447\u0456 12-\u0457 \u0445\u0440\u043E\u043C\u043E\u0441\u043E\u043C\u0438. \u0414\u043E\u0432\u0436\u0438\u043D\u0430 \u043F\u043E\u043B\u0456\u043F\u0435\u043F\u0442\u0438\u0434\u043D\u043E\u0433\u043E \u043B\u0430\u043D\u0446\u044E\u0433\u0430 \u0431\u0456\u043B\u043A\u0430 \u0441\u0442\u0430\u043D\u043E\u0432\u0438\u0442\u044C 1 342 \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442, \u0430 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044F\u0440\u043D\u0430 \u043C\u0430\u0441\u0430 \u2014 148 098. \u041F\u043E\u0441\u043B\u0456\u0434\u043E\u0432\u043D\u0456\u0441\u0442\u044C \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442 A: \u0410\u043B\u0430\u043D\u0456\u043DC: \u0426\u0438\u0441\u0442\u0435\u0457\u043DD: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430E: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430F: \u0424\u0435\u043D\u0456\u043B\u0430\u043B\u0430\u043D\u0456\u043DG: \u0413\u043B\u0456\u0446\u0438\u043DH: \u0413\u0456\u0441\u0442\u0438\u0434\u0438\u043DI: \u0406\u0437\u043E\u043B\u0435\u0439\u0446\u0438\u043DK: \u041B\u0456\u0437\u0438\u043DL: \u041B\u0435\u0439\u0446\u0438\u043DM: \u041C\u0435\u0442\u0456\u043E\u043D\u0456\u043DN: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043DP: \u041F\u0440\u043E\u043B\u0456\u043DQ: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043DR: \u0410\u0440\u0433\u0456\u043D\u0456\u043DS: \u0421\u0435\u0440\u0438\u043DT: \u0422\u0440\u0435\u043E\u043D\u0456\u043DV: \u0412\u0430\u043B\u0456\u043DW: \u0422\u0440\u0438\u043F\u0442\u043E\u0444\u0430\u043D Y: \u0422\u0438\u0440\u043E\u0437\u0438\u043D"@uk . . . . . . .