. . . . . . . . . . . . . . . . . . . . . . . . "Thyroid Transcription Factor -1"@fr . "Der Thyroidale Transkriptionsfaktor 1, abgek\u00FCrzt TTF1, ist ein Protein, das als Transkriptionsfaktor unter anderem die Transkription von bestimmten Genen in der Schilddr\u00FCse kontrolliert. TTF1 wird vom Hom\u00F6obox-Gen NK2 homeobox 1, abgek\u00FCrzt NKX2-1, codiert und ist nicht nur im Menschen, sondern auch in einer Vielzahl von Tierarten nachgewiesen worden."@de . . . . "NKX2-1 (\u0430\u043D\u0433\u043B. NK2 homeobox 1) \u2013 \u0431\u0456\u043B\u043E\u043A, \u044F\u043A\u0438\u0439 \u043A\u043E\u0434\u0443\u0454\u0442\u044C\u0441\u044F \u043E\u0434\u043D\u043E\u0439\u043C\u0435\u043D\u043D\u0438\u043C \u0433\u0435\u043D\u043E\u043C, \u0440\u043E\u0437\u0442\u0430\u0448\u043E\u0432\u0430\u043D\u0438\u043C \u0443 \u043B\u044E\u0434\u0435\u0439 \u043D\u0430 \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u043C\u0443 \u043F\u043B\u0435\u0447\u0456 14-\u0457 \u0445\u0440\u043E\u043C\u043E\u0441\u043E\u043C\u0438. \u0414\u043E\u0432\u0436\u0438\u043D\u0430 \u043F\u043E\u043B\u0456\u043F\u0435\u043F\u0442\u0438\u0434\u043D\u043E\u0433\u043E \u043B\u0430\u043D\u0446\u044E\u0433\u0430 \u0431\u0456\u043B\u043A\u0430 \u0441\u0442\u0430\u043D\u043E\u0432\u0438\u0442\u044C 371 \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442, \u0430 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044F\u0440\u043D\u0430 \u043C\u0430\u0441\u0430 \u2014 38 596. \u041F\u043E\u0441\u043B\u0456\u0434\u043E\u0432\u043D\u0456\u0441\u0442\u044C \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442 A: \u0410\u043B\u0430\u043D\u0456\u043DC: \u0426\u0438\u0441\u0442\u0435\u0457\u043DD: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430E: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430F: \u0424\u0435\u043D\u0456\u043B\u0430\u043B\u0430\u043D\u0456\u043DG: \u0413\u043B\u0456\u0446\u0438\u043DH: \u0413\u0456\u0441\u0442\u0438\u0434\u0438\u043DI: \u0406\u0437\u043E\u043B\u0435\u0439\u0446\u0438\u043DK: \u041B\u0456\u0437\u0438\u043DL: \u041B\u0435\u0439\u0446\u0438\u043DM: \u041C\u0435\u0442\u0456\u043E\u043D\u0456\u043DN: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043DP: \u041F\u0440\u043E\u043B\u0456\u043DQ: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043DR: \u0410\u0440\u0433\u0456\u043D\u0456\u043DS: \u0421\u0435\u0440\u0438\u043DT: \u0422\u0440\u0435\u043E\u043D\u0456\u043DV: \u0412\u0430\u043B\u0456\u043DW: \u0422\u0440\u0438\u043F\u0442\u043E\u0444\u0430\u043D Y: \u0422\u0438\u0440\u043E\u0437\u0438\u043D \u041A\u043E\u0434\u043E\u0432\u0430\u043D\u0438\u0439 \u0433\u0435\u043D\u043E\u043C \u0431\u0456\u043B\u043E\u043A \u0437\u0430 \u0444\u0443\u043D\u043A\u0446\u0456\u044F\u043C\u0438 \u043D\u0430\u043B\u0435\u0436\u0438\u0442\u044C \u0434\u043E \u0440\u0435\u043F\u0440\u0435\u0441\u043E\u0440\u0456\u0432, \u0430\u043A\u0442\u0438\u0432\u0430\u0442\u043E\u0440\u0456\u0432, \u0444\u043E\u0441\u0444\u043E\u043F\u0440\u043E\u0442\u0435\u0457\u043D\u0456\u0432. \u0417\u0430\u0434\u0456\u044F\u043D\u0438\u0439 \u0443 \u0442\u0430\u043A\u0438\u0445 \u0431\u0456\u043E\u043B\u043E\u0433\u0456\u0447\u043D\u0438\u0445 \u043F\u0440\u043E\u0446\u0435\u0441\u0430\u0445, \u044F\u043A \u0442\u0440\u0430\u043D\u0441\u043A\u0440\u0438\u043F\u0446\u0456\u044F, \u0440\u0435\u0433\u0443\u043B\u044F\u0446\u0456\u044F \u0442\u0440\u0430\u043D\u0441\u043A\u0440\u0438\u043F\u0446\u0456\u0457, \u0431\u0456\u043E\u043B\u043E\u0433\u0456\u0447\u043D\u0456 \u0440\u0438\u0442\u043C\u0438, \u0430\u043B\u044C\u0442\u0435\u0440\u043D\u0430\u0442\u0438\u0432\u043D\u0438\u0439 \u0441\u043F\u043B\u0430\u0439\u0441\u0438\u043D\u0433. \u0411\u0456\u043B\u043E\u043A \u043C\u0430\u0454 \u0441\u0430\u0439\u0442 \u0434\u043B\u044F \u0437\u0432'\u044F\u0437\u0443\u0432\u0430\u043D\u043D\u044F \u0437 \u0414\u041D\u041A. \u041B\u043E\u043A\u0430\u043B\u0456\u0437\u043E\u0432\u0430\u043D\u0438\u0439 \u0443 \u044F\u0434\u0440\u0456."@uk . . . . . . . . "NK2 homeobox 1"@en . . "O NK2 homeobox 1 (NKX2-1), tamb\u00E9m conhecido como fator de transcri\u00E7\u00E3o da tireoide 1 (TTF-1, do ingl\u00EAs \"thyroid transcription factor 1\"), \u00E9 uma prote\u00EDna que, em humanos, \u00E9 codificada pelo gene NKX2-1. O fator de transcri\u00E7\u00E3o da tireoide 1 regula a transcri\u00E7\u00E3o de genes espec\u00EDficos da tireoide, do pulm\u00E3o e do dienc\u00E9falo. Ele \u00E9 utilizado na anatomia patol\u00F3gica como um marcador para determinar se um tumor teve origem no pulm\u00E3o ou na tireoide. NKX2.1 \u00E9 fundamental para o desenvolvimento fetal das estruturas pulmonares. O padr\u00E3o dorso-ventral da express\u00E3o de NKX2.1 forma o limite ventral no intestino anterior anterior. NKX2.1 \u00E9 expresso apenas em c\u00E9lulas selecionadas na parede ventral do , e n\u00E3o \u00E9 expresso na parede dorsal, de onde o es\u00F4fago emergir\u00E1. O nocaute de NKX2.1 em camundongos resulta no desenvolvimento de uma traqueia encurtada que \u00E9 fundida ao es\u00F4fago, com os br\u00F4nquios conectando diretamente esse tubo compartilhado aos pulm\u00F5es. Isso se assemelha a uma , que \u00E9 uma condi\u00E7\u00E3o cong\u00EAnita rara em humanos. Al\u00E9m disso, estruturas pulmonares distais n\u00E3o se desenvolvem nesses camundongos knockout. A ramifica\u00E7\u00E3o dos pulm\u00F5es nesses camundongos n\u00E3o ocorreu al\u00E9m dos br\u00F4nquios da haste principal, resultando em pulm\u00F5es menores em tamanho em cerca de 50% em compara\u00E7\u00E3o com os camundongos do tipo selvagem. O revestimento epitelial dessas estruturas distais n\u00E3o mostrou evid\u00EAncia de diferencia\u00E7\u00E3o em c\u00E9lulas especializadas. Este revestimento \u00E9 composto por c\u00E9lulas epiteliais colunares e c\u00E9lulas epiteliais ciliadas dispersas. O epit\u00E9lio proximal dos pulm\u00F5es apresentou diferencia\u00E7\u00E3o normal, indicando que a diferencia\u00E7\u00E3o proximal \u00E9 independente de NXK2.1. NKX2.1 \u00E9 inicialmente expresso em todo o epit\u00E9lio, mas \u00E9 suprimido em um padr\u00E3o proximal-distal \u00E0 medida que o pulm\u00E3o continua a se desenvolver."@pt . "Factor de transcripci\u00F3n tiroidea 1 (TTF-1)"@es . "NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene."@en . . . . . . "Fator de transcri\u00E7\u00E3o da tireoide 1"@pt . . "El factor de transcripci\u00F3n tiroidea 1 (TTF-1), tambi\u00E9n conocido como NK2 homeobox 1 (NKX2-1), es una prote\u00EDna qu\u00E9 en los humanos est\u00E1 codificada por el gen NKX2-1.\u200B\u200B"@es . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Thyroidaler Transkriptionsfaktor 1"@de . . . . . . . . . . . "El factor de transcripci\u00F3n tiroidea 1 (TTF-1), tambi\u00E9n conocido como NK2 homeobox 1 (NKX2-1), es una prote\u00EDna qu\u00E9 en los humanos est\u00E1 codificada por el gen NKX2-1.\u200B\u200B"@es . . . "c e Thyroid transcription factor-1 (TTF-1) est une prot\u00E9ine qui r\u00E9gule la transcription de g\u00E8nes sp\u00E9cifiques \u00E0 la thyro\u00EFde, au poumon et au dienc\u00E9phale. Elle est aussi connue comme thyroid specific enhancer binding protein. Son g\u00E8ne est le NKX2-1 situ\u00E9 sur le chromosome 14 humain. On s'en sert en anatomo-pathologie comme marqueur pour d\u00E9terminer si une tumeur provient des poumons ou de la thyro\u00EFde. Les cellules TTF-1 positives se trouvent dans les pneumocytes de type II et dans les cellules de Clara dans le poumon. Dans la thyro\u00EFde, les cellules folliculaires et para folliculaires sont positives. Pour les cancers du poumon, les ad\u00E9nocarcinomes sont habituellement positifs, alors que les carcinomes \u00E0 cellules squameuses et \u00E0 grandes cellules le sont rarement. Les carcinomes \u00E0 petites cellules (de n'importe quel site primaire) sont habituellement positifs."@fr . . "c e Thyroid transcription factor-1 (TTF-1) est une prot\u00E9ine qui r\u00E9gule la transcription de g\u00E8nes sp\u00E9cifiques \u00E0 la thyro\u00EFde, au poumon et au dienc\u00E9phale. Elle est aussi connue comme thyroid specific enhancer binding protein. Son g\u00E8ne est le NKX2-1 situ\u00E9 sur le chromosome 14 humain. On s'en sert en anatomo-pathologie comme marqueur pour d\u00E9terminer si une tumeur provient des poumons ou de la thyro\u00EFde."@fr . . . . . . . . . . . . . . . "NKX2-1"@uk . "NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene."@en . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Der Thyroidale Transkriptionsfaktor 1, abgek\u00FCrzt TTF1, ist ein Protein, das als Transkriptionsfaktor unter anderem die Transkription von bestimmten Genen in der Schilddr\u00FCse kontrolliert. TTF1 wird vom Hom\u00F6obox-Gen NK2 homeobox 1, abgek\u00FCrzt NKX2-1, codiert und ist nicht nur im Menschen, sondern auch in einer Vielzahl von Tierarten nachgewiesen worden."@de . . . "O NK2 homeobox 1 (NKX2-1), tamb\u00E9m conhecido como fator de transcri\u00E7\u00E3o da tireoide 1 (TTF-1, do ingl\u00EAs \"thyroid transcription factor 1\"), \u00E9 uma prote\u00EDna que, em humanos, \u00E9 codificada pelo gene NKX2-1. O fator de transcri\u00E7\u00E3o da tireoide 1 regula a transcri\u00E7\u00E3o de genes espec\u00EDficos da tireoide, do pulm\u00E3o e do dienc\u00E9falo. Ele \u00E9 utilizado na anatomia patol\u00F3gica como um marcador para determinar se um tumor teve origem no pulm\u00E3o ou na tireoide."@pt . . . . "19270"^^ . "14723432"^^ . . . . "1116530659"^^ . . . . . . . . . . "NKX2-1 (\u0430\u043D\u0433\u043B. NK2 homeobox 1) \u2013 \u0431\u0456\u043B\u043E\u043A, \u044F\u043A\u0438\u0439 \u043A\u043E\u0434\u0443\u0454\u0442\u044C\u0441\u044F \u043E\u0434\u043D\u043E\u0439\u043C\u0435\u043D\u043D\u0438\u043C \u0433\u0435\u043D\u043E\u043C, \u0440\u043E\u0437\u0442\u0430\u0448\u043E\u0432\u0430\u043D\u0438\u043C \u0443 \u043B\u044E\u0434\u0435\u0439 \u043D\u0430 \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u043C\u0443 \u043F\u043B\u0435\u0447\u0456 14-\u0457 \u0445\u0440\u043E\u043C\u043E\u0441\u043E\u043C\u0438. \u0414\u043E\u0432\u0436\u0438\u043D\u0430 \u043F\u043E\u043B\u0456\u043F\u0435\u043F\u0442\u0438\u0434\u043D\u043E\u0433\u043E \u043B\u0430\u043D\u0446\u044E\u0433\u0430 \u0431\u0456\u043B\u043A\u0430 \u0441\u0442\u0430\u043D\u043E\u0432\u0438\u0442\u044C 371 \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442, \u0430 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044F\u0440\u043D\u0430 \u043C\u0430\u0441\u0430 \u2014 38 596. \u041F\u043E\u0441\u043B\u0456\u0434\u043E\u0432\u043D\u0456\u0441\u0442\u044C \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442 A: \u0410\u043B\u0430\u043D\u0456\u043DC: \u0426\u0438\u0441\u0442\u0435\u0457\u043DD: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430E: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430F: \u0424\u0435\u043D\u0456\u043B\u0430\u043B\u0430\u043D\u0456\u043DG: \u0413\u043B\u0456\u0446\u0438\u043DH: \u0413\u0456\u0441\u0442\u0438\u0434\u0438\u043DI: \u0406\u0437\u043E\u043B\u0435\u0439\u0446\u0438\u043DK: \u041B\u0456\u0437\u0438\u043DL: \u041B\u0435\u0439\u0446\u0438\u043DM: \u041C\u0435\u0442\u0456\u043E\u043D\u0456\u043DN: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043DP: \u041F\u0440\u043E\u043B\u0456\u043DQ: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043DR: \u0410\u0440\u0433\u0456\u043D\u0456\u043DS: \u0421\u0435\u0440\u0438\u043DT: \u0422\u0440\u0435\u043E\u043D\u0456\u043DV: \u0412\u0430\u043B\u0456\u043DW: \u0422\u0440\u0438\u043F\u0442\u043E\u0444\u0430\u043D Y: \u0422\u0438\u0440\u043E\u0437\u0438\u043D"@uk . . . . . . . . . . . . . . .