. . . . . . . . . . . "1"^^ . . . "\u5149\u88C2\u5408\u9176\uFF08Photolyases\uFF0CEC 4.1.99.3\uFF09\u70BA\u4E00\u7A2EDNA\u4FEE\u5FA9\u9175\u7D20\uFF0C\u5C08\u9580\u4FEE\u5FA9\u906D\u53D7\u7D2B\u5916\u7DDA\u7834\u58DE\u7684DNA\u3002\u6B64\u9175\u7D20\u7684\u4F5C\u7528\u9700\u8981\u53EF\u898B\u5149\u5354\u52A9\u6D3B\u5316\u53CADNA\u4FEE\u5FA9\u3002\u5149\u88C2\u5408\u9176\u4FEE\u5FA9DNA\u7684\u904E\u7A0B\u7A31\u70BA\u5149\u5B78\u6D3B\u4F5C\u7528\uFF08photoreactivation\uFF09\u3002 \u7531\u7CFB\u7D71\u767C\u751F\u5B78\u4F86\u770B\uFF0C\u5149\u88C2\u5408\u9176\u662F\u4E00\u500B\u76F8\u7576\u53E4\u8001\u7684\u9175\u7D20\uFF0C\u5F9E\u7D30\u83CC\u3001\u771F\u83CC\uFF0C\u5230\u52D5\u7269\u9AD4\u5167\u90FD\u6709\uFF0C\u4E14\u5728\u690D\u7269\u9AD4\u5167\u5C24\u70BA\u91CD\u8981\u3002\u4EBA\u985E\u7B49\u80CE\u76E4\u54FA\u4E73\u985E\u9AD4\u5167\u5247\u4E26\u7121\u6B64\u9175\u7D20\u6D3B\u6027\uFF0C\u800C\u662F\u4F7F\u7528\u53E6\u4E00\u7A2E\u8F03\u7121\u6548\u7387\u7684\u6838\u82F7\u9178\u5207\u9664\u4FEE\u5FA9\u6CD5\u4F86\u53D6\u4EE3\u5149\u88C2\u5408\u9176\u3002 DNA\u4E2D\u76F8\u9130\u7684\u80F8\u817A\u5627\u5576\u53D7\u5230\u7D2B\u5916\u7DDA\u7684\u7167\u5C04\u6642\uFF0C\u6703\u5F62\u6210\u5171\u50F9\u9375\uFF0C\u5F62\u6210\u74B0\u4E01\u70F7\u6A4B\uFF0C\u7A31\u70BA\u80F8\u817A\u5627\u5576\u4E8C\u805A\u9AD4\u3002\u5F62\u6210\u80F8\u817A\u5627\u5576\u4E8C\u805A\u9AD4\u7684\u57FA\u56E0\u6703\u5C0E\u81F4\u57FA\u56E0\u5728\u8907\u88FD\u548C\u8F49\u9304\u6642\u51FA\u73FE\u932F\u8AA4\u3002\u5149\u88C2\u5408\u9176\u6703\u63A5\u5728DNA\u4E0A\uFF0C\u5207\u9664\u80F8\u817A\u5627\u5576\u4E8C\u805A\u9AD4\uFF0C\u4E26\u4FEE\u5FA9\u56DE\u539F\u672C\u7684\u6A23\u5B50\u3002 \u5149\u88C2\u5408\u9176\u70BA\u4E00\u7A2E\u9EC4\u7D20\u86CB\u767D\uFF0C\u5167\u542B\u5169\u500B\u6355\u5149\u6027\u8F85\u56E0\u5B50\u3002\u6240\u6709\u7684\u5149\u88C2\u5408\u9176\u90FD\u542B\u6709FADH\u2212\uFF0C\u4E26\u53EF\u6839\u64DA\u4ED6\u7684\u7B2C\u4E8C\u8F14\u56E0\u5B50\u5206\u70BA\u5169\u985E\u3002\u7B2C\u4E00\u985E\u70BA\u8449\u9178\u6027\u5149\u88C2\u5408\u9176\uFF0C\u5176\u7B2C\u4E8C\u8F14\u56E0\u5B50\u7684\u6210\u5206\u70BA\u6B21\u7532\u57FA\u56DB\u6C2B\u8449\u9178\u8776\u5464\uFF08Methenyltetrahydrofolate\uFF0CMTHF\uFF09\uFF0C\u7A31\u3002\u7B2C\u4E8C\u985E\u5247\u70BA\u6027\u5149\u88C2\u5408\u9176\uFF0C\u5176\u7B2C\u4E8C\u8F14\u56E0\u5B50\u70BA8-\u7FA5-7,8-\u4E8C\u7532\u57FA-5-\u812B\u6C2E\u6838\u9EC3\u7D20\uFF088-hydroxy-7,8-didemethyl-5-deazariboflavin\uFF0C8-HDF\uFF09\u3002FAD\u672C\u8EAB\u5373\u6709\u9175\u7D20\u6D3B\u6027\uFF0C\u7B2C\u4E8C\u8F14\u56E0\u5B50\u5247\u53EF\u5728\u4F4E\u5149\u72C0\u614B\u4E0B\u52A0\u901F\u53CD\u61C9\u9032\u884C\u3002\u88AB\u5149\u6D3B\u5316\u7684\u5149\u88C2\u5408\u9176\u6703\u5C07FADH\u2212\u7684\u96FB\u5B50\uFF0C\u8F49\u79FB\u7D66\u80F8\u817A\u5627\u5576\u4E8C\u805A\u9AD4\u4F86\u88C2\u89E3\u4E8C\u805A\u9AD4\u3002"@zh . . "PF03441"@en . . "Photolyases (EC 4.1.99.3) are DNA repair enzymes that repair damage caused by exposure to ultraviolet light. These enzymes require visible light (from the violet/blue end of the spectrum) both for their own activation and for the actual DNA repair. The DNA repair mechanism involving photolyases is called photoreactivation. They mainly convert pyrimidine dimers into a normal pair of pyrimidine bases."@en . . . "4.1"^^ . . "La photolyase est une enzyme qui r\u00E9pare certains des dommages caus\u00E9s dans l'ADN par les ultraviolets et en particulier les dim\u00E8res de thymine ou plus g\u00E9n\u00E9ralement de pyrimidine. La prot\u00E9ine agit sous l'action d'une lumi\u00E8re bleue ou UV proche, qui excite un cofacteur : la flavine r\u00E9duite. Celle-ci peut alors transf\u00E9rer un \u00E9lectron au dim\u00E8re de pyrimidines, ce qui entra\u00EEne la scission de ce dim\u00E8re et la r\u00E9paration de l'ADN. Ce m\u00E9canisme tr\u00E8s rapide (de l'ordre de la pico seconde) est encore mal connu mais il implique deux photo-r\u00E9actions bien distinctes :"@fr . . . . "Les fotoliases, en angl\u00E8s:Photolyases, ( 4.1.99.3) s\u00F3n enzims reparadors d'ADN que reparen els danys causats per l'exposici\u00F3 a la llum ultraviolada. El mecanisme d'aquests enzims requereix la llum visible, preferentment del violeta/blau del'espectre, i el mecanisme es coneix com la fotoreactivaci\u00F3. Les fotoliases s\u00F3n flavoprote\u00EFnes. Aquest enzim actua fent la transfer\u00E8ncia d'electrons. Algunes cremes solars contenen fotoliasa entre els seus ingredients, i pretenen que proporcionen una acci\u00F3 reparadora respecte al dany per llum ultraviolada en la pell."@ca . "3249930"^^ . . . . "Les fotoliases, en angl\u00E8s:Photolyases, ( 4.1.99.3) s\u00F3n enzims reparadors d'ADN que reparen els danys causats per l'exposici\u00F3 a la llum ultraviolada. El mecanisme d'aquests enzims requereix la llum visible, preferentment del violeta/blau del'espectre, i el mecanisme es coneix com la fotoreactivaci\u00F3. Filogen\u00E8ticament la fotoliasa \u00E9s un enzim antic el qual es presenta i \u00E9s funcional en moltes esp\u00E8cies, des dels bacteris als fongs i en les plantes i els animals. La fotoliasa \u00E9s particularment important en la reparaci\u00F3 del dany indu\u00EFt per la llum ultraviolada en les plantes. El mecanisme de la fotoliasa ja no funciona en els humans i altres mam\u00EDfers placentaris que es fa en el menys eficient sistema de la reparaci\u00F3 per excisi\u00F3 dels nucle\u00F2tids. Les fotoliases s\u00F3n flavoprote\u00EFnes. Aquest enzim actua fent la transfer\u00E8ncia d'electrons. Algunes cremes solars contenen fotoliasa entre els seus ingredients, i pretenen que proporcionen una acci\u00F3 reparadora respecte al dany per llum ultraviolada en la pell."@ca . . "\u30D5\u30A9\u30C8\u30EA\u30A2\u30FC\u30BC"@ja . . . . . . . . "1109604041"^^ . "Fotoliaza"@pl . "Las fotoliasas (EC 4.1.99.3) son , las cuales reparan el da\u00F1o causado por la exposici\u00F3n a la luz ultravioleta. Este mecanismo enzim\u00E1tico requiere de luz visible, preferentemente de longitudes de onda entre 400 y 500 nm (colores violeta y azul) para actuar, en un proceso conocido como fotorreactivaci\u00F3n.\u200B"@es . . . "Photolyase"@fr . . . . "La deossiribodipirimidina foto-liasi (o fotoliasi) \u00E8 un enzima, appartenente alla classe delle liasi che lega specificamente i filamenti di DNA danneggiati dall'esposizione a radiazione ultravioletta, le quali provocano la formazione di dimeri di pirimidina e di 6-4 fotoprodotti. I dimeri di pirimidina si producono quando due basi azotate adiacenti (timina e\\o citosina) sullo stesso filamento di DNA vengono legate covalentemente fra di loro. La fotoliasi ha alta affinit\u00E0 per queste strutture chimiche, alle quali si lega reversibilmente e le ripara. Catalizza la seguente reazione:"@it . "La deossiribodipirimidina foto-liasi (o fotoliasi) \u00E8 un enzima, appartenente alla classe delle liasi che lega specificamente i filamenti di DNA danneggiati dall'esposizione a radiazione ultravioletta, le quali provocano la formazione di dimeri di pirimidina e di 6-4 fotoprodotti. I dimeri di pirimidina si producono quando due basi azotate adiacenti (timina e\\o citosina) sullo stesso filamento di DNA vengono legate covalentemente fra di loro. La fotoliasi ha alta affinit\u00E0 per queste strutture chimiche, alle quali si lega reversibilmente e le ripara. Catalizza la seguente reazione: (in DNA) = 2 residui pirimidinici (in DNA) Questo enzima funziona come un meccanismo di riparazione del DNA quando la luce di lunghezza d'onda compresa fra 320 e 370 nm lo colpisce attivandolo. La reazione enzimatica prevede la rottura del dimero e la ricostituzione della struttura corretta delle basi (fotoriattivazione).Questo enzima \u00E8 una flavoproteina ed agisce attraverso il trasferimento di elettroni. Nella reazione redox la molecola FAD agisce da donatore di elettroni, mentre il dimero agisce da accettore di elettroniLa fotoliasi \u00E8 presente e funzionante nei procarioti \u00E8 presente negli eucarioti inferiori come il lievito, dove si ritiene abbia per\u00F2 un ruolo minore ed \u00E8 assente nelle cellule umane."@it . . . . . . "Deossiribodipirimidina foto-liasi"@it . "Fotoliaza \u2013 enzym wi\u0105\u017C\u0105cy komplementarne nici DNA i rozbijaj\u0105cy , kt\u00F3re zazwyczaj powstaj\u0105 wskutek ekspozycji na promieniowanie ultrafioletowe. Dimery pirymidynowe powstaj\u0105, gdy para tymin lub cytozyn tej samej nici DNA po\u0142\u0105czy si\u0119 ze sob\u0105, tworz\u0105c zniekszta\u0142cenie struktury podw\u00F3jnej helisy w miejscu uszkodzenia. Fotoliaza wykazuje wysokie powinowactwo do tych zmienionych fragment\u00F3w DNA i odwracalnie wi\u0105\u017Ce zmienion\u0105 cz\u0105steczk\u0119 DNA, a nast\u0119pnie rozbija dimer, wykorzystuj\u0105c zaabsorbowan\u0105 energi\u0119 \u015Bwietln\u0105. Fotoliazy jako enzymy naprawy DNA dzia\u0142aj\u0105, gdy na kom\u00F3rk\u0119 pada promieniowanie (preferencyjnie niebieska i fioletowa cz\u0119\u015B\u0107 pasma). Ten proces naprawy jest nazywany fotoreaktywacj\u0105."@pl . . . . . . . . . . . . . "A fotoliase \u00E9 uma enzima que se liga \u00E0s fitas complementares de ADN e que quebra d\u00EDmeros pirimid\u00EDnicos causados por exposi\u00E7\u00E3o a luz ultravioleta. Este d\u00EDmeros formam-se quando um par de bases de timina ou citosina existentes na mesma fita de ADN, se juntam, formando protuber\u00E2ncias (les\u00F5es). A fotoliase tem uma alta afinidade para essas les\u00F5es no ADN e ligam-se de maneira irrevers\u00EDvel ao d\u00EDmero, quebrando atrav\u00E9s do uso de energia luminosa. Esta enzima s\u00F3 funciona no reparo de ADN quando luz vis\u00EDvel est\u00E1 dispon\u00EDvel (especialmente na banda violeta/azul do espectro)."@pt . . . "Photolyasen sind Enzyme, die an der Reparatur der DNA beteiligt sind. Sie bewerkstelligen die Aufl\u00F6sung von (CPD) und , welche bei Belichtung der DNA mit ultravioletter Strahlung entstehen."@de . . . . . . . . . . . . . . . . . . . "Fotoliaza \u2013 enzym wi\u0105\u017C\u0105cy komplementarne nici DNA i rozbijaj\u0105cy , kt\u00F3re zazwyczaj powstaj\u0105 wskutek ekspozycji na promieniowanie ultrafioletowe. Dimery pirymidynowe powstaj\u0105, gdy para tymin lub cytozyn tej samej nici DNA po\u0142\u0105czy si\u0119 ze sob\u0105, tworz\u0105c zniekszta\u0142cenie struktury podw\u00F3jnej helisy w miejscu uszkodzenia. Fotoliaza wykazuje wysokie powinowactwo do tych zmienionych fragment\u00F3w DNA i odwracalnie wi\u0105\u017Ce zmienion\u0105 cz\u0105steczk\u0119 DNA, a nast\u0119pnie rozbija dimer, wykorzystuj\u0105c zaabsorbowan\u0105 energi\u0119 \u015Bwietln\u0105. Fotoliazy jako enzymy naprawy DNA dzia\u0142aj\u0105, gdy na kom\u00F3rk\u0119 pada promieniowanie (preferencyjnie niebieska i fioletowa cz\u0119\u015B\u0107 pasma). Ten proces naprawy jest nazywany fotoreaktywacj\u0105. Fotoliazy s\u0105 flawoproteinami i posiadaj\u0105 dwa absorbuj\u0105ce \u015Bwiat\u0142o kofaktory. Wszystkie fotoliazy zawieraj\u0105 zredukowany FAD; w zale\u017Cno\u015Bci od drugiego kofaktora, kt\u00F3rym mo\u017Ce by\u0107 metylenotetrahydrofolianu (MTHF) albo 8-hydroksy-7,8-didemetylo-5-deazaryboflawiny (8-HDF), dziel\u0105 si\u0119 na fotoliazy folianowe i fotoliazy deazaflawinowe, odpowiednio. Chocia\u017C tylko FAD odpowiada za aktywno\u015B\u0107 enzymatyczn\u0105 fotoliaz, drugi kofaktor znacz\u0105co przyspiesza tempo reakcji w warunkach s\u0142abego o\u015Bwietlenia. Reakcja enzymatyczna zachodzi dzi\u0119ki przep\u0142ywowi elektron\u00F3w, gdzie zredukowany kofaktor FADH2 dzia\u0142a jako donor elektron\u00F3w, rozbijaj\u0105cych dimer pirymidynowy. Fotoliazy s\u0105 obecne u prokariont\u00F3w, a tak\u017Ce u ni\u017Cszych eukariont\u00F3w (dro\u017Cd\u017Cy). Nie stwierdzono bia\u0142ek o aktywno\u015Bci fotoliaz u ludzi. Jednak\u017Ce wiele wy\u017Cszych eukariont\u00F3w, w tym cz\u0142owiek, wykazuje ekspresj\u0119 bia\u0142ek o znacznej homologii wobec fotoliaz, zwanych kryptochromami, kt\u00F3re s\u0105 zaanga\u017Cowane w zale\u017Cne od nas\u0142onecznienia czynno\u015Bci biologiczne."@pl . . "Las fotoliasas (EC 4.1.99.3) son , las cuales reparan el da\u00F1o causado por la exposici\u00F3n a la luz ultravioleta. Este mecanismo enzim\u00E1tico requiere de luz visible, preferentemente de longitudes de onda entre 400 y 500 nm (colores violeta y azul) para actuar, en un proceso conocido como fotorreactivaci\u00F3n.\u200B La fotoliasa es una enzima filogen\u00E9ticamente antigua, presente en organismos procariotas, y muchos eucariotas. Es particularmente importante en la reparaci\u00F3n del da\u00F1o producido por UV en plantas. Sin embargo, en humanos y otros mam\u00EDferos placentarios, no existe sistema de fotorreactivaci\u00F3n, en cambio s\u00F3lo presentan mecanismos de .\u200B El da\u00F1o en el ADN causado por efecto de la luz ultravioleta, se manifiesta en la formaci\u00F3n de . Estos d\u00EDmeros, forman una suerte de bulto en la estructura primaria del ADN, obstaculizando el paso de la ADN polimerasa. La enzima fotoliasa act\u00FAa separando el anillo de ciclobutano de los d\u00EDmeros de timina, reconociendo los lugares defectuosos en la hebra de ADN, y abriendo los dos enlaces C-C del anillo de ciclobutano con la ayuda de dos cofactores que absorben la luz en el espectro visible mencionada anteriormente."@es . . . . . . "deoxyribodipyrimidine photo-lyase"@en . . . . . . . . "Fotoliase"@pt . . . . . "Cryptochrome/photolyase, C-terminal, FAD binding"@en . . . . . . . . . "A UV radiation induced thymine-thymine cyclobutane dimer is the type of DNA damage which is repaired by DNA photolyase. Note: The above diagram is incorrectly labelled as thymine as the structures lack 5-methyl groups."@en . "Fotoliasa"@es . . "\u0414\u041D\u041A-\u0444\u043E\u0442\u043E\u043B\u0438\u00E1\u0437\u0430 (\u043E\u0442 \u0433\u0440\u0435\u0447. \u03C6\u03C9\u03C4\u03BF\u03C2 \u2014 \u0441\u0432\u0435\u0442 \u0438 \u0433\u0440\u0435\u0447. \u03BB\u03CD\u03BD\u03C9 \u2014 \u043E\u0441\u043B\u0430\u0431\u043B\u044F\u0442\u044C, \u0440\u0430\u0437\u0432\u044F\u0437\u044B\u0432\u0430\u0442\u044C, \u0448\u0438\u0444\u0440 \u041A\u0424 4.1.99.3) \u2014 \u043E\u0434\u0438\u043D \u0438\u0437 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u043E\u0432 \u0440\u0435\u043F\u0430\u0440\u0430\u0446\u0438\u0438 \u0414\u041D\u041A, \u0430\u043A\u0442\u0438\u0432\u0430\u0446\u0438\u044F \u043A\u043E\u0442\u043E\u0440\u043E\u0433\u043E \u043F\u0440\u043E\u0438\u0441\u0445\u043E\u0434\u0438\u0442 \u043F\u043E\u0434 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435\u043C \u0432\u0438\u0434\u0438\u043C\u043E\u0433\u043E \u0441\u0432\u0435\u0442\u0430. \u0414\u041D\u041A-\u0444\u043E\u0442\u043E\u043B\u0438\u0430\u0437\u0430 \u0443\u0434\u0430\u043B\u044F\u0435\u0442 \u0444\u043E\u0442\u043E\u043F\u0440\u043E\u0434\u0443\u043A\u0442\u044B \u0438 \u043F\u0438\u0440\u0438\u043C\u0438\u0434\u0438\u043D-\u043F\u0438\u0440\u0438\u043C\u0438\u0434\u0438\u043D\u043E\u0432\u044B\u0435 \u0434\u0438\u043C\u0435\u0440\u044B, \u043E\u0431\u0440\u0430\u0437\u0443\u044E\u0449\u0438\u0435\u0441\u044F \u0432 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u0435 \u0414\u041D\u041A \u043F\u043E\u0434 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435\u043C \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u0432\u043E\u043B\u043D\u043E\u0432\u043E\u0433\u043E \u0423\u0424-\u0438\u0437\u043B\u0443\u0447\u0435\u043D\u0438\u044F. \u041F\u0440\u043E\u0446\u0435\u0441\u0441, \u0432 \u043A\u043E\u0442\u043E\u0440\u043E\u043C \u0443\u0447\u0430\u0441\u0442\u0432\u0443\u0435\u0442 \u0444\u0435\u0440\u043C\u0435\u043D\u0442, \u043D\u0430\u0437\u044B\u0432\u0430\u0435\u0442\u0441\u044F \u0444\u043E\u0442\u043E\u0440\u0435\u0430\u043A\u0442\u0438\u0432\u0430\u0446\u0438\u0435\u0439. \u0422\u0430\u043A\u0438\u0435 \u0444\u043E\u0442\u043E\u0440\u0435\u0430\u043A\u0442\u0438\u0432\u0438\u0440\u0443\u044E\u0449\u0438\u0435 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u044B \u0438\u043C\u0435\u044E\u0442\u0441\u044F \u0443 \u0431\u0430\u043A\u0442\u0435\u0440\u0438\u0439 \u0438 \u043D\u0438\u0437\u0448\u0438\u0445 \u044D\u0443\u043A\u0430\u0440\u0438\u043E\u0442\u0438\u0447\u0435\u0441\u043A\u0438\u0445 \u043E\u0440\u0433\u0430\u043D\u0438\u0437\u043C\u043E\u0432, \u043D\u043E \u0432 \u043A\u043B\u0435\u0442\u043A\u0430\u0445 \u043C\u043B\u0435\u043A\u043E\u043F\u0438\u0442\u0430\u044E\u0449\u0438\u0445 \u043E\u043D\u0438 \u043D\u0435 \u043E\u0431\u043D\u0430\u0440\u0443\u0436\u0435\u043D\u044B."@ru . . "A fotoliase \u00E9 uma enzima que se liga \u00E0s fitas complementares de ADN e que quebra d\u00EDmeros pirimid\u00EDnicos causados por exposi\u00E7\u00E3o a luz ultravioleta. Este d\u00EDmeros formam-se quando um par de bases de timina ou citosina existentes na mesma fita de ADN, se juntam, formando protuber\u00E2ncias (les\u00F5es). A fotoliase tem uma alta afinidade para essas les\u00F5es no ADN e ligam-se de maneira irrevers\u00EDvel ao d\u00EDmero, quebrando atrav\u00E9s do uso de energia luminosa. Esta enzima s\u00F3 funciona no reparo de ADN quando luz vis\u00EDvel est\u00E1 dispon\u00EDvel (especialmente na banda violeta/azul do espectro)."@pt . . . . "\u0414\u041D\u041A-\u0444\u043E\u0442\u043E\u043B\u0438\u0430\u0437\u0430"@ru . . . "12454"^^ . . . . . . . . . . "Photolyase"@en . . . "FAD_binding_7"@en . . . . . . . "\u30D5\u30A9\u30C8\u30EA\u30A2\u30FC\u30BC\uFF08Photolyase\uFF09\uFF08EC 4.1.99.3)\u306F\u3001\u7D2B\u5916\u7DDA\u306B\u66DD\u9732\u3055\u308C\u305F\u3053\u3068\u306B\u3088\u3063\u3066\u8D77\u3053\u308B\u30D4\u30EA\u30DF\u30B8\u30F3\u4E8C\u91CF\u4F53\u306E\u751F\u6210\u306B\u3088\u308BDNA\u640D\u50B7\u3092\u4FEE\u5FA9\u3059\u308BDNA\u4FEE\u5FA9\u9175\u7D20\u3067\u3042\u308B\u3002\u3053\u306E\u9175\u7D20\u306E\u30E1\u30AB\u30CB\u30BA\u30E0\u3068\u3057\u3066\u3001\u53EF\u8996\u5149\u3001\u7279\u306B\u53EF\u8996\u5149\u30B9\u30DA\u30AF\u30C8\u30EB\u306E\u7AEF\u306E\u7D2B\u8272\u3084\u9752\u8272\u306E\u5149\u3092\u512A\u5148\u7684\u306B\u5FC5\u8981\u3068\u3057\u3066\u304A\u308A\u3001\u5149\u56DE\u5FA9\u9175\u7D20\u3068\u3057\u3066\u77E5\u3089\u308C\u3066\u3044\u308B\u3002"@ja . "\u30D5\u30A9\u30C8\u30EA\u30A2\u30FC\u30BC\uFF08Photolyase\uFF09\uFF08EC 4.1.99.3)\u306F\u3001\u7D2B\u5916\u7DDA\u306B\u66DD\u9732\u3055\u308C\u305F\u3053\u3068\u306B\u3088\u3063\u3066\u8D77\u3053\u308B\u30D4\u30EA\u30DF\u30B8\u30F3\u4E8C\u91CF\u4F53\u306E\u751F\u6210\u306B\u3088\u308BDNA\u640D\u50B7\u3092\u4FEE\u5FA9\u3059\u308BDNA\u4FEE\u5FA9\u9175\u7D20\u3067\u3042\u308B\u3002\u3053\u306E\u9175\u7D20\u306E\u30E1\u30AB\u30CB\u30BA\u30E0\u3068\u3057\u3066\u3001\u53EF\u8996\u5149\u3001\u7279\u306B\u53EF\u8996\u5149\u30B9\u30DA\u30AF\u30C8\u30EB\u306E\u7AEF\u306E\u7D2B\u8272\u3084\u9752\u8272\u306E\u5149\u3092\u512A\u5148\u7684\u306B\u5FC5\u8981\u3068\u3057\u3066\u304A\u308A\u3001\u5149\u56DE\u5FA9\u9175\u7D20\u3068\u3057\u3066\u77E5\u3089\u308C\u3066\u3044\u308B\u3002"@ja . . . . "\u5149\u88C2\u5408\u9176\uFF08Photolyases\uFF0CEC 4.1.99.3\uFF09\u70BA\u4E00\u7A2EDNA\u4FEE\u5FA9\u9175\u7D20\uFF0C\u5C08\u9580\u4FEE\u5FA9\u906D\u53D7\u7D2B\u5916\u7DDA\u7834\u58DE\u7684DNA\u3002\u6B64\u9175\u7D20\u7684\u4F5C\u7528\u9700\u8981\u53EF\u898B\u5149\u5354\u52A9\u6D3B\u5316\u53CADNA\u4FEE\u5FA9\u3002\u5149\u88C2\u5408\u9176\u4FEE\u5FA9DNA\u7684\u904E\u7A0B\u7A31\u70BA\u5149\u5B78\u6D3B\u4F5C\u7528\uFF08photoreactivation\uFF09\u3002 \u7531\u7CFB\u7D71\u767C\u751F\u5B78\u4F86\u770B\uFF0C\u5149\u88C2\u5408\u9176\u662F\u4E00\u500B\u76F8\u7576\u53E4\u8001\u7684\u9175\u7D20\uFF0C\u5F9E\u7D30\u83CC\u3001\u771F\u83CC\uFF0C\u5230\u52D5\u7269\u9AD4\u5167\u90FD\u6709\uFF0C\u4E14\u5728\u690D\u7269\u9AD4\u5167\u5C24\u70BA\u91CD\u8981\u3002\u4EBA\u985E\u7B49\u80CE\u76E4\u54FA\u4E73\u985E\u9AD4\u5167\u5247\u4E26\u7121\u6B64\u9175\u7D20\u6D3B\u6027\uFF0C\u800C\u662F\u4F7F\u7528\u53E6\u4E00\u7A2E\u8F03\u7121\u6548\u7387\u7684\u6838\u82F7\u9178\u5207\u9664\u4FEE\u5FA9\u6CD5\u4F86\u53D6\u4EE3\u5149\u88C2\u5408\u9176\u3002 DNA\u4E2D\u76F8\u9130\u7684\u80F8\u817A\u5627\u5576\u53D7\u5230\u7D2B\u5916\u7DDA\u7684\u7167\u5C04\u6642\uFF0C\u6703\u5F62\u6210\u5171\u50F9\u9375\uFF0C\u5F62\u6210\u74B0\u4E01\u70F7\u6A4B\uFF0C\u7A31\u70BA\u80F8\u817A\u5627\u5576\u4E8C\u805A\u9AD4\u3002\u5F62\u6210\u80F8\u817A\u5627\u5576\u4E8C\u805A\u9AD4\u7684\u57FA\u56E0\u6703\u5C0E\u81F4\u57FA\u56E0\u5728\u8907\u88FD\u548C\u8F49\u9304\u6642\u51FA\u73FE\u932F\u8AA4\u3002\u5149\u88C2\u5408\u9176\u6703\u63A5\u5728DNA\u4E0A\uFF0C\u5207\u9664\u80F8\u817A\u5627\u5576\u4E8C\u805A\u9AD4\uFF0C\u4E26\u4FEE\u5FA9\u56DE\u539F\u672C\u7684\u6A23\u5B50\u3002 \u5149\u88C2\u5408\u9176\u70BA\u4E00\u7A2E\u9EC4\u7D20\u86CB\u767D\uFF0C\u5167\u542B\u5169\u500B\u6355\u5149\u6027\u8F85\u56E0\u5B50\u3002\u6240\u6709\u7684\u5149\u88C2\u5408\u9176\u90FD\u542B\u6709FADH\u2212\uFF0C\u4E26\u53EF\u6839\u64DA\u4ED6\u7684\u7B2C\u4E8C\u8F14\u56E0\u5B50\u5206\u70BA\u5169\u985E\u3002\u7B2C\u4E00\u985E\u70BA\u8449\u9178\u6027\u5149\u88C2\u5408\u9176\uFF0C\u5176\u7B2C\u4E8C\u8F14\u56E0\u5B50\u7684\u6210\u5206\u70BA\u6B21\u7532\u57FA\u56DB\u6C2B\u8449\u9178\u8776\u5464\uFF08Methenyltetrahydrofolate\uFF0CMTHF\uFF09\uFF0C\u7A31\u3002\u7B2C\u4E8C\u985E\u5247\u70BA\u6027\u5149\u88C2\u5408\u9176\uFF0C\u5176\u7B2C\u4E8C\u8F14\u56E0\u5B50\u70BA8-\u7FA5-7,8-\u4E8C\u7532\u57FA-5-\u812B\u6C2E\u6838\u9EC3\u7D20\uFF088-hydroxy-7,8-didemethyl-5-deazariboflavin\uFF0C8-HDF\uFF09\u3002FAD\u672C\u8EAB\u5373\u6709\u9175\u7D20\u6D3B\u6027\uFF0C\u7B2C\u4E8C\u8F14\u56E0\u5B50\u5247\u53EF\u5728\u4F4E\u5149\u72C0\u614B\u4E0B\u52A0\u901F\u53CD\u61C9\u9032\u884C\u3002\u88AB\u5149\u6D3B\u5316\u7684\u5149\u88C2\u5408\u9176\u6703\u5C07FADH\u2212\u7684\u96FB\u5B50\uFF0C\u8F49\u79FB\u7D66\u80F8\u817A\u5627\u5576\u4E8C\u805A\u9AD4\u4F86\u88C2\u89E3\u4E8C\u805A\u9AD4\u3002 \u9664\u4E86\u7B2C\u4E8C\u8F14\u56E0\u5B50\u4E4B\u5916\uFF0C\u5149\u88C2\u5408\u9176\u4E5F\u53EF\u6839\u64DA\u5E8F\u5217\u76F8\u4F3C\u6027\u5206\u70BA\u5169\u7A2E\uFF0C\u7B2C\u4E00\u7A2E\u4E3B\u8981\u5728\u9769\u862D\u6C0F\u9670\u6027\u83CC\u3001\u967D\u6027\u83CC\u3001\u55DC\u9E7D\u53E4\u83CC\u3001\u771F\u83CC\uFF0C\u548C\u690D\u7269\u9AD4\u5167\u3002Proteins containing this domain also include Arabidopsis thaliana s 1 and 2, which are blue light photoreceptors that mediate blue light-induced gene expression and modulation of circadian rhythms. \u3001\u53EF\u4EE5\u5C07\u5149\u88C2\u5408\u9176\u5206\u70BA\u5169\u985E\u3002The first class contains enzymes from Gram-negative and Gram-positive bacteria, the halophilic archaebacteria Halobacterium halobium,\u4EE5\u53CA\u771F\u83CC\u8207\u690D\u7269\u3002\u963F\u62C9\u4F2F\u82A5\u7684 1\u82072\u4EA6\u542B\u6709\u6B64\u7A2E\u7D50\u69CB\u57DF\uFF0C\u4F5C\u70BA\u4FC3\u9032\u85CD\u5149\u57FA\u56E0\u8868\u73FE\u8207\u8ABF\u6574\u663C\u591C\u8282\u5F8B\u7684\u5149\u53D7\u9AD4\u3002 The second class are named cryptochrome (Cry), found in species as diverse as Drosophila, Arabidopsis, Synechocystis, and Human (Cry-DASH). These were previously assumed to have no DNA repair activity because of negligible activity on double-stranded DNA. A study by A. Sancar and P. Selby provided evidence to suggest this branch of cryptochromes have photolyase activity with a high degree of specificity for cyclobutane pyrimidine dimers in single-stranded DNA. Their study showed that VcCry1 from Vibrio cholerae, X1Cry from Xenopus laevis, and AtCry3 from Arabidopsis thaliana all had photolyase activity on UV irradiated ssDNA in vitro. \u6709\u4E9B\u9632\u66EC\u6CB9\u542B\u6709\u6B64\u9175\u7D20\uFF0C\u5BA3\u7A31\u53EF\u4EE5\u6CBB\u7652\u7D2B\u5916\u7DDA\u66EC\u50B7\u3002"@zh . . . "A:214-492 A:214-492 A:176-418\nA:176-418 B:202-469 D:207-472\nA:207-472 :207-472 A:207-472\nA:207-472 A:207-472 A:207-472\nB:213-453"@en . . . . "IPR005101"@en . "La photolyase est une enzyme qui r\u00E9pare certains des dommages caus\u00E9s dans l'ADN par les ultraviolets et en particulier les dim\u00E8res de thymine ou plus g\u00E9n\u00E9ralement de pyrimidine. La prot\u00E9ine agit sous l'action d'une lumi\u00E8re bleue ou UV proche, qui excite un cofacteur : la flavine r\u00E9duite. Celle-ci peut alors transf\u00E9rer un \u00E9lectron au dim\u00E8re de pyrimidines, ce qui entra\u00EEne la scission de ce dim\u00E8re et la r\u00E9paration de l'ADN. Ce m\u00E9canisme tr\u00E8s rapide (de l'ordre de la pico seconde) est encore mal connu mais il implique deux photo-r\u00E9actions bien distinctes : \n* La photoactivation sert \u00E0 mettre le cofacteur FAD de l\u2019enzyme sous la forme doublement r\u00E9duite (FADH\u2013) \u00E0 partir de la forme semi-r\u00E9duite (FADH\u00B0, un radical qui est assez stable dans la photolyase). Cette r\u00E9action peut \u00EAtre d\u00E9clench\u00E9e par la lumi\u00E8re visible (jusqu\u2019\u00E0 680 nm) absorb\u00E9e par FADH\u00B0. \n* La photor\u00E9paration a lieu lorsque l\u2019enzyme se lie \u00E0 l\u2019ADN qui porte un CPD (Cyclobutane Pyrimidine Dim\u00E8re : Liaisons covalentes entre 2 pyrimidines : g\u00E9n\u00E9r\u00E9 par UV). . Cette r\u00E9action n\u00E9cessite l\u2019excitation du FADH\u2013 par un photon bleu ou proche UV. La photolyase est pr\u00E9sente et fonctionnelle chez les procaryotes. Elle est \u00E9galement pr\u00E9sente chez de nombreux eucaryotes, comme les levures, les plantes et la plupart des animaux. Elle n'est pas pr\u00E9sente chez les mammif\u00E8res placentaires, et donc chez l'homme, mais existe en revanche chez les mammif\u00E8res marsupiaux. De nombreux eucaryotes multicellulaires poss\u00E8dent de plus une prot\u00E9ine homologue appel\u00E9e cryptochrome, d\u00E9pourvue d'activit\u00E9 de r\u00E9paration de l'ADN, qui est impliqu\u00E9e dans des activit\u00E9s r\u00E9gulatrices photosensibles comme celle influen\u00E7ant les rythmes circadiens."@fr . . . . . . . . . . "\u5149\u88C2\u5408\u9176"@zh . . "Photolyasen sind Enzyme, die an der Reparatur der DNA beteiligt sind. Sie bewerkstelligen die Aufl\u00F6sung von (CPD) und , welche bei Belichtung der DNA mit ultravioletter Strahlung entstehen."@de . "FAD_binding_7" . . . . . "\u0414\u041D\u041A-\u0444\u043E\u0442\u043E\u043B\u0438\u00E1\u0437\u0430 (\u043E\u0442 \u0433\u0440\u0435\u0447. \u03C6\u03C9\u03C4\u03BF\u03C2 \u2014 \u0441\u0432\u0435\u0442 \u0438 \u0433\u0440\u0435\u0447. \u03BB\u03CD\u03BD\u03C9 \u2014 \u043E\u0441\u043B\u0430\u0431\u043B\u044F\u0442\u044C, \u0440\u0430\u0437\u0432\u044F\u0437\u044B\u0432\u0430\u0442\u044C, \u0448\u0438\u0444\u0440 \u041A\u0424 4.1.99.3) \u2014 \u043E\u0434\u0438\u043D \u0438\u0437 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u043E\u0432 \u0440\u0435\u043F\u0430\u0440\u0430\u0446\u0438\u0438 \u0414\u041D\u041A, \u0430\u043A\u0442\u0438\u0432\u0430\u0446\u0438\u044F \u043A\u043E\u0442\u043E\u0440\u043E\u0433\u043E \u043F\u0440\u043E\u0438\u0441\u0445\u043E\u0434\u0438\u0442 \u043F\u043E\u0434 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435\u043C \u0432\u0438\u0434\u0438\u043C\u043E\u0433\u043E \u0441\u0432\u0435\u0442\u0430. \u0414\u041D\u041A-\u0444\u043E\u0442\u043E\u043B\u0438\u0430\u0437\u0430 \u0443\u0434\u0430\u043B\u044F\u0435\u0442 \u0444\u043E\u0442\u043E\u043F\u0440\u043E\u0434\u0443\u043A\u0442\u044B \u0438 \u043F\u0438\u0440\u0438\u043C\u0438\u0434\u0438\u043D-\u043F\u0438\u0440\u0438\u043C\u0438\u0434\u0438\u043D\u043E\u0432\u044B\u0435 \u0434\u0438\u043C\u0435\u0440\u044B, \u043E\u0431\u0440\u0430\u0437\u0443\u044E\u0449\u0438\u0435\u0441\u044F \u0432 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u0435 \u0414\u041D\u041A \u043F\u043E\u0434 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435\u043C \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u0432\u043E\u043B\u043D\u043E\u0432\u043E\u0433\u043E \u0423\u0424-\u0438\u0437\u043B\u0443\u0447\u0435\u043D\u0438\u044F. \u041F\u0440\u043E\u0446\u0435\u0441\u0441, \u0432 \u043A\u043E\u0442\u043E\u0440\u043E\u043C \u0443\u0447\u0430\u0441\u0442\u0432\u0443\u0435\u0442 \u0444\u0435\u0440\u043C\u0435\u043D\u0442, \u043D\u0430\u0437\u044B\u0432\u0430\u0435\u0442\u0441\u044F \u0444\u043E\u0442\u043E\u0440\u0435\u0430\u043A\u0442\u0438\u0432\u0430\u0446\u0438\u0435\u0439. \u0422\u0430\u043A\u0438\u0435 \u0444\u043E\u0442\u043E\u0440\u0435\u0430\u043A\u0442\u0438\u0432\u0438\u0440\u0443\u044E\u0449\u0438\u0435 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u044B \u0438\u043C\u0435\u044E\u0442\u0441\u044F \u0443 \u0431\u0430\u043A\u0442\u0435\u0440\u0438\u0439 \u0438 \u043D\u0438\u0437\u0448\u0438\u0445 \u044D\u0443\u043A\u0430\u0440\u0438\u043E\u0442\u0438\u0447\u0435\u0441\u043A\u0438\u0445 \u043E\u0440\u0433\u0430\u043D\u0438\u0437\u043C\u043E\u0432, \u043D\u043E \u0432 \u043A\u043B\u0435\u0442\u043A\u0430\u0445 \u043C\u043B\u0435\u043A\u043E\u043F\u0438\u0442\u0430\u044E\u0449\u0438\u0445 \u043E\u043D\u0438 \u043D\u0435 \u043E\u0431\u043D\u0430\u0440\u0443\u0436\u0435\u043D\u044B."@ru . . . "Photolyasen"@de . . "3904"^^ . . . . . . "A deazaflavin photolyase from Anacystis nidulans, illustrating the two light-harvesting cofactors: FADH\u2212 and 8-HDF ."@en . . . "Fotoliasa"@ca . . . "Photolyases (EC 4.1.99.3) are DNA repair enzymes that repair damage caused by exposure to ultraviolet light. These enzymes require visible light (from the violet/blue end of the spectrum) both for their own activation and for the actual DNA repair. The DNA repair mechanism involving photolyases is called photoreactivation. They mainly convert pyrimidine dimers into a normal pair of pyrimidine bases."@en . . . . . . . . "37290"^^ . "PDOC00331"@en . .