. . . . . "19050"^^ . . . . "Les thiazolidin\u00E9diones, aussi connues sous le nom de glitazones, sont les d\u00E9riv\u00E9es de la thiazolidin\u00E9dione, un compos\u00E9 h\u00E9t\u00E9rocyclique constitu\u00E9 d'un cycle comportant trois atomes de carbone, un de soufre et un d'azote (thiazolidine), les atomes de carbone entourant l'atome d'azote portant \u00E9galement chacun un groupe carbonyle (comme dans le succinimide). Ces compos\u00E9s forment une classe de m\u00E9dicament utilis\u00E9 dans les cas de diab\u00E8te de type 2. Ils ont \u00E9t\u00E9 introduits \u00E0 la fin des ann\u00E9es 1990 par Hiroshi Imoto et Takashi Sohda mais retir\u00E9s du march\u00E9 en France en 2011. Ils agissent en se liant aux PPARs-Gamma, r\u00E9cepteurs nucl\u00E9aires."@fr . "I tiazolidindioni (chiamati anche glitazoni o tiazolidinedioni) sono una classe di farmaci in grado di aumentare la sensibilit\u00E0 all'insulina nei tessuti. Essi inducono l'espressione di geni coinvolti soprattutto nel metabolismo glucidico, lipidico e nella trasduzione del segnale veicolato dall'insulina. Sul finire degli anni novanta sono stati pertanto introdotti nella terapia del diabete mellito di tipo 2."@it . . . . . . . . . . . . "As tiazolidinedionas (TZDs), tamb\u00E9m conhecidas como glitazonas, s\u00E3o uma classe de f\u00E1rmacos usados no tratamento de diabetes mellitus tipo 2 e outras enfermidades relacionadas. Foram introduzidas no final dos anos 1990s. As tiazolidinedionas melhoram a sensibilidade dos tecidos brancos \u00E0 insulina por atuar como agonistas seletivos de receptores da insulina localizados no n\u00FAcleo celular. Os exemplos de f\u00E1rmacos mais utilizados dessa classe s\u00E3o pioglitazona, rosiglitazona, troglitazona e"@pt . . . . . "\u062B\u064A\u0627\u0632\u0648\u0644\u064A\u062F\u064A\u0646\u062F\u064A\u0648\u0646 (\u0628\u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629: Thiazolidinedione)\u200F \u0647\u064A \u0641\u0626\u0629 \u0645\u0646 \u0627\u0644\u0623\u062F\u0648\u064A\u0629 \u0627\u0644\u062A\u064A \u062A\u064F\u0633\u062A\u062E\u062F\u0645 \u0641\u064A \u0639\u0644\u0627\u062C \u0645\u0631\u0636 \u0633\u0643\u0631\u064A \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062B\u0627\u0646\u064A."@ar . . . . . . . . . . . . . "The thiazolidinediones /\u03B8a\u026A.\u0259\u02CCzo\u028Al\u026Adi\u02D0n\u02C8da\u026A.o\u028An/, abbreviated as TZD, also known as glitazones after the prototypical drug ciglitazone, are a class of heterocyclic compounds consisting of a five-membered C3NS ring. The term usually refers to a family of drugs used in the treatment of diabetes mellitus type 2 that were introduced in the late 1990s."@en . . . . . . . . . . . . "\u567B\u5511\u70F7\u4E8C\u916E\u985E \uFF08\u82F1\u8A9E\uFF1AThiazolidinedione\uFF0CTZDs) \u65BC1990\u5E74\u4EE3\u958B\u59CB\u4F7F\u7528\uFF0C\u4E3B\u8981\u7528\u65BC\u6CBB\u76422\u578B\u7CD6\u5C3F\u75C5"@zh . . . . . . . . . . . . . . "Tiazolidinediona"@es . "Tiazolidinediona"@pt . . . . . . . "Thiazolidinedione"@fr . . . . . . . . . "\u0422\u0456\u0430\u0437\u043E\u043B\u0456\u0434\u0438\u043D\u0435\u0434\u0456\u043E\u043D\u0438"@uk . . . . "1123812401"^^ . . "\u0422\u0438\u0430\u0437\u043E\u043B\u0438\u0434\u0438\u043D\u0434\u0438\u043E\u043D\u044B (\u0433\u043B\u0438\u0442\u0430\u0437\u043E\u043D\u044B) \u2014 5-\u0437\u0430\u043C\u0435\u0449\u0435\u043D\u043D\u044B\u0435 \u043F\u0440\u043E\u0438\u0437\u0432\u043E\u0434\u043D\u044B\u0435 1,3-\u0442\u0438\u0430\u0437\u043E\u043B\u0438\u0434\u0438\u043D-2,4-\u0434\u0438\u043E\u043D\u0430. \u041C\u043D\u043E\u0433\u0438\u0435 \u0442\u0438\u0430\u0437\u043E\u043B\u0438\u0434\u0438\u043D\u0434\u0438\u043E\u043D\u044B \u0438\u0441\u043F\u043E\u043B\u044C\u0437\u0443\u044E\u0442\u0441\u044F \u0432 \u043A\u0430\u0447\u0435\u0441\u0442\u0432\u0435 \u0433\u0438\u043F\u043E\u0433\u043B\u0438\u043A\u0435\u043C\u0438\u0447\u0435\u0441\u043A\u0438\u0445 \u0441\u0440\u0435\u0434\u0441\u0442\u0432. \u041D\u0430 2006 \u0433\u043E\u0434 \u0432 \u0420\u043E\u0441\u0441\u0438\u0438 \u0431\u044B\u043B\u0438 \u0437\u0430\u0440\u0435\u0433\u0438\u0441\u0442\u0440\u0438\u0440\u043E\u0432\u0430\u043D\u044B \u0434\u0432\u0430 \u043F\u0440\u0435\u043F\u0430\u0440\u0430\u0442\u0430 \u043A\u043B\u0430\u0441\u0441\u0430 \u0442\u0438\u0430\u0437\u043E\u043B\u0438\u0434\u0438\u043D\u0434\u0438\u043E\u043D\u043E\u0432 \u2014 \u043F\u0438\u043E\u0433\u043B\u0438\u0442\u0430\u0437\u043E\u043D \u0438 \u0440\u043E\u0441\u0438\u0433\u043B\u0438\u0442\u0430\u0437\u043E\u043D."@ru . . "I tiazolidindioni (chiamati anche glitazoni o tiazolidinedioni) sono una classe di farmaci in grado di aumentare la sensibilit\u00E0 all'insulina nei tessuti. Essi inducono l'espressione di geni coinvolti soprattutto nel metabolismo glucidico, lipidico e nella trasduzione del segnale veicolato dall'insulina. Sul finire degli anni novanta sono stati pertanto introdotti nella terapia del diabete mellito di tipo 2."@it . "\u30C1\u30A2\u30BE\u30EA\u30B8\u30F3\u30B8\u30AA\u30F3"@ja . . . . . . . . . . . . . . . . . . "\u0422\u0456\u0430\u0437\u043E\u043B\u0456\u0434\u0438\u043D\u0435\u0434\u0456\u043E\u043D\u0438 (\u0430\u043D\u0433\u043B. Thiazolidinedione), \u044F\u043A\u0456 \u043F\u043E\u0437\u043D\u0430\u0447\u0430\u044E\u0442\u044C\u0441\u044F \u0430\u0431\u0440\u0435\u0432\u0456\u0430\u0442\u0443\u0440\u043E\u044E TZD, \u0432\u0456\u0434\u043E\u043C\u0456 \u0442\u0430\u043A\u043E\u0436 \u044F\u043A \u0433\u043B\u0456\u0442\u0430\u0437\u043E\u043D\u0438 \u043F\u0456\u0441\u043B\u044F \u0440\u043E\u0437\u0440\u043E\u0431\u043A\u0438 \u043F\u0435\u0440\u0448\u043E\u0433\u043E \u043F\u0440\u0435\u043F\u0430\u0440\u0430\u0442\u0443 \u0433\u0440\u0443\u043F\u0438 \u2014 \u0446\u0435 \u043A\u043B\u0430\u0441 \u0433\u0435\u0442\u0435\u0440\u043E\u0446\u0438\u043A\u043B\u0456\u0447\u043D\u0438\u0445 \u0441\u043F\u043E\u043B\u0443\u043A, \u0434\u043E \u0441\u043A\u043B\u0430\u0434\u0443 \u044F\u043A\u0438\u0445 \u0432\u0445\u043E\u0434\u0438\u0442\u044C \u043F'\u044F\u0442\u0438\u0447\u043B\u0435\u043D\u043D\u0435 \u043A\u0456\u043B\u044C\u0446\u0435 C3NS. \u0426\u044F \u043D\u0430\u0437\u0432\u0430 \u0437\u0430\u0441\u0442\u043E\u0441\u043E\u0432\u0443\u0454\u0442\u044C\u0441\u044F \u0434\u043B\u044F \u0433\u0440\u0443\u043F\u0438 \u043B\u0456\u043A\u0430\u0440\u0441\u044C\u043A\u0438\u0445 \u0437\u0430\u0441\u043E\u0431\u0456\u0432, \u044F\u043A\u0456 \u0437\u0430\u0441\u0442\u043E\u0441\u043E\u0432\u0443\u044E\u0442\u044C\u0441\u044F \u0434\u043B\u044F \u043B\u0456\u043A\u0443\u0432\u0430\u043D\u043D\u044F \u0446\u0443\u043A\u0440\u043E\u0432\u043E\u0433\u043E \u0434\u0456\u0430\u0431\u0435\u0442\u0443 \u0406\u0406 \u0442\u0438\u043F\u0443, \u0442\u0430 \u0437\u0430\u0441\u0442\u043E\u0441\u043E\u0432\u0443\u044E\u0442\u044C\u0441\u044F \u0432 \u043A\u043B\u0456\u043D\u0456\u0447\u043D\u0456\u0439 \u043F\u0440\u0430\u043A\u0442\u0438\u0446\u0456 \u0437 90-\u0445 \u0440\u043E\u043A\u0456\u0432 \u0425\u0425 \u0441\u0442\u043E\u043B\u0456\u0442\u0442\u044F."@uk . . . "Insulin-Sensitizer"@de . . . . "575620"^^ . . . "Les thiazolidin\u00E9diones, aussi connues sous le nom de glitazones, sont les d\u00E9riv\u00E9es de la thiazolidin\u00E9dione, un compos\u00E9 h\u00E9t\u00E9rocyclique constitu\u00E9 d'un cycle comportant trois atomes de carbone, un de soufre et un d'azote (thiazolidine), les atomes de carbone entourant l'atome d'azote portant \u00E9galement chacun un groupe carbonyle (comme dans le succinimide). Ces compos\u00E9s forment une classe de m\u00E9dicament utilis\u00E9 dans les cas de diab\u00E8te de type 2. Ils ont \u00E9t\u00E9 introduits \u00E0 la fin des ann\u00E9es 1990 par Hiroshi Imoto et Takashi Sohda mais retir\u00E9s du march\u00E9 en France en 2011."@fr . . . . . . . . . . . "\u0422\u0438\u0430\u0437\u043E\u043B\u0438\u0434\u0438\u043D\u0434\u0438\u043E\u043D\u044B (\u0433\u043B\u0438\u0442\u0430\u0437\u043E\u043D\u044B) \u2014 5-\u0437\u0430\u043C\u0435\u0449\u0435\u043D\u043D\u044B\u0435 \u043F\u0440\u043E\u0438\u0437\u0432\u043E\u0434\u043D\u044B\u0435 1,3-\u0442\u0438\u0430\u0437\u043E\u043B\u0438\u0434\u0438\u043D-2,4-\u0434\u0438\u043E\u043D\u0430. \u041C\u043D\u043E\u0433\u0438\u0435 \u0442\u0438\u0430\u0437\u043E\u043B\u0438\u0434\u0438\u043D\u0434\u0438\u043E\u043D\u044B \u0438\u0441\u043F\u043E\u043B\u044C\u0437\u0443\u044E\u0442\u0441\u044F \u0432 \u043A\u0430\u0447\u0435\u0441\u0442\u0432\u0435 \u0433\u0438\u043F\u043E\u0433\u043B\u0438\u043A\u0435\u043C\u0438\u0447\u0435\u0441\u043A\u0438\u0445 \u0441\u0440\u0435\u0434\u0441\u0442\u0432. \u041D\u0430 2006 \u0433\u043E\u0434 \u0432 \u0420\u043E\u0441\u0441\u0438\u0438 \u0431\u044B\u043B\u0438 \u0437\u0430\u0440\u0435\u0433\u0438\u0441\u0442\u0440\u0438\u0440\u043E\u0432\u0430\u043D\u044B \u0434\u0432\u0430 \u043F\u0440\u0435\u043F\u0430\u0440\u0430\u0442\u0430 \u043A\u043B\u0430\u0441\u0441\u0430 \u0442\u0438\u0430\u0437\u043E\u043B\u0438\u0434\u0438\u043D\u0434\u0438\u043E\u043D\u043E\u0432 \u2014 \u043F\u0438\u043E\u0433\u043B\u0438\u0442\u0430\u0437\u043E\u043D \u0438 \u0440\u043E\u0441\u0438\u0433\u043B\u0438\u0442\u0430\u0437\u043E\u043D."@ru . . "As tiazolidinedionas (TZDs), tamb\u00E9m conhecidas como glitazonas, s\u00E3o uma classe de f\u00E1rmacos usados no tratamento de diabetes mellitus tipo 2 e outras enfermidades relacionadas. Foram introduzidas no final dos anos 1990s. As tiazolidinedionas melhoram a sensibilidade dos tecidos brancos \u00E0 insulina por atuar como agonistas seletivos de receptores da insulina localizados no n\u00FAcleo celular. Os exemplos de f\u00E1rmacos mais utilizados dessa classe s\u00E3o pioglitazona, rosiglitazona, troglitazona e"@pt . . . . . . . . . . . . . . . . . "\u30C1\u30A2\u30BE\u30EA\u30B8\u30F3\u30B8\u30AA\u30F3\uFF08Thiazolidinedione\uFF09\u306F\u30B0\u30EA\u30BF\u30BE\u30F3\uFF08Glitazone\uFF09\u3068\u3082\u547C\u3070\u308C\u308B\u5316\u5408\u7269\u3067\u3001\u305D\u306E\u8A98\u5C0E\u4F53\uFF08\u30C1\u30A2\u30BE\u30EA\u30B8\u30F3\u7CFB\u7CD6\u5C3F\u75C5\u85AC\u3001TZD\uFF09\u306F2\u578B\u7CD6\u5C3F\u75C5\u306E\u6CBB\u7642\u306B\u7528\u3044\u3089\u308C\u308B\u30021995\u5E74\u306B\u6700\u521D\u306E\u30C1\u30A2\u30BE\u30EA\u30B8\u30F3\u7CFB\u533B\u85AC\u54C1\u304C\u627F\u8A8D\u3055\u308C\u305F\u3002 \u30C1\u30A2\u30BE\u30EA\u30B8\u30F3\u30B8\u30AA\u30F3\u306E\u9178\u7D20\u539F\u5B50\u30921\u3064\u786B\u9EC4\u539F\u5B50\u306B\u7F6E\u304D\u63DB\u3048\u305F\u3082\u306E\u3092\u30ED\u30C0\u30CB\u30F3\u3068\u8A00\u3046\u3002"@ja . . . . . "\u30C1\u30A2\u30BE\u30EA\u30B8\u30F3\u30B8\u30AA\u30F3\uFF08Thiazolidinedione\uFF09\u306F\u30B0\u30EA\u30BF\u30BE\u30F3\uFF08Glitazone\uFF09\u3068\u3082\u547C\u3070\u308C\u308B\u5316\u5408\u7269\u3067\u3001\u305D\u306E\u8A98\u5C0E\u4F53\uFF08\u30C1\u30A2\u30BE\u30EA\u30B8\u30F3\u7CFB\u7CD6\u5C3F\u75C5\u85AC\u3001TZD\uFF09\u306F2\u578B\u7CD6\u5C3F\u75C5\u306E\u6CBB\u7642\u306B\u7528\u3044\u3089\u308C\u308B\u30021995\u5E74\u306B\u6700\u521D\u306E\u30C1\u30A2\u30BE\u30EA\u30B8\u30F3\u7CFB\u533B\u85AC\u54C1\u304C\u627F\u8A8D\u3055\u308C\u305F\u3002 \u30C1\u30A2\u30BE\u30EA\u30B8\u30F3\u30B8\u30AA\u30F3\u306E\u9178\u7D20\u539F\u5B50\u30921\u3064\u786B\u9EC4\u539F\u5B50\u306B\u7F6E\u304D\u63DB\u3048\u305F\u3082\u306E\u3092\u30ED\u30C0\u30CB\u30F3\u3068\u8A00\u3046\u3002"@ja . "Glitazone, genannt auch Insulin-Sensitizer und (nach dem chemischen Grundger\u00FCst, einem Thiazol-2,4-dion) Thiazolidindione, sind eine Gruppe von Wirkstoffen, die in der Therapie des Diabetes mellitus Typ 2 angewendet werden. Sie geh\u00F6ren zu den oral wirksamen Antidiabetika. Der Name der Gruppe weist bereits auf die Wirkungsweise, eine Empfindlichmachung des Gewebes auf Insulin, hin. Das k\u00F6rpereigene Insulin ist daraufhin wieder in der Lage, erh\u00F6hte Blutzuckerspiegel zu senken. Im Juni 2011 war nur noch der Wirkstoff Pioglitazon im Handel, allerdings r\u00E4t das Bundesinstitut f\u00FCr Arzneimittel und Medizinprodukte von dessen Einnahme ab."@de . . . . . . . . . . . . "\u567B\u5511\u70F7\u4E8C\u916E\u985E \uFF08\u82F1\u8A9E\uFF1AThiazolidinedione\uFF0CTZDs) \u65BC1990\u5E74\u4EE3\u958B\u59CB\u4F7F\u7528\uFF0C\u4E3B\u8981\u7528\u65BC\u6CBB\u76422\u578B\u7CD6\u5C3F\u75C5"@zh . . . . . . . . . "Las tiazolidinedionas (TZD) son una clase de medicamentos introducidos a finales de los a\u00F1os 1990 como terapia para la diabetes mellitus tipo 2 y otras enfermedades relacionadas. Las tiazolidinedionas mejoran la sensibilidad de los tejidos blancos a la insulina por actuar como agonistas selectivos de receptores de la insulina localizados en el n\u00FAcleo celular."@es . . . . . . . . . . . . . "Glitazone, genannt auch Insulin-Sensitizer und (nach dem chemischen Grundger\u00FCst, einem Thiazol-2,4-dion) Thiazolidindione, sind eine Gruppe von Wirkstoffen, die in der Therapie des Diabetes mellitus Typ 2 angewendet werden. Sie geh\u00F6ren zu den oral wirksamen Antidiabetika. Der Name der Gruppe weist bereits auf die Wirkungsweise, eine Empfindlichmachung des Gewebes auf Insulin, hin. Das k\u00F6rpereigene Insulin ist daraufhin wieder in der Lage, erh\u00F6hte Blutzuckerspiegel zu senken. Im Juni 2011 war nur noch der Wirkstoff Pioglitazon im Handel, allerdings r\u00E4t das Bundesinstitut f\u00FCr Arzneimittel und Medizinprodukte von dessen Einnahme ab."@de . . . . . . . . . . "\u062B\u064A\u0627\u0632\u0648\u0644\u064A\u062F\u064A\u0646\u062F\u064A\u0648\u0646 (\u0628\u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629: Thiazolidinedione)\u200F \u0647\u064A \u0641\u0626\u0629 \u0645\u0646 \u0627\u0644\u0623\u062F\u0648\u064A\u0629 \u0627\u0644\u062A\u064A \u062A\u064F\u0633\u062A\u062E\u062F\u0645 \u0641\u064A \u0639\u0644\u0627\u062C \u0645\u0631\u0636 \u0633\u0643\u0631\u064A \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062B\u0627\u0646\u064A."@ar . . . . "\u567B\u5511\u70F7\u4E8C\u916E\u985E"@zh . . . . . . . "Glitazone"@de . . . . . . . . . "Tiazolidindioni"@it . . . "Thiazolidinedione"@en . . . . . . "The thiazolidinediones /\u03B8a\u026A.\u0259\u02CCzo\u028Al\u026Adi\u02D0n\u02C8da\u026A.o\u028An/, abbreviated as TZD, also known as glitazones after the prototypical drug ciglitazone, are a class of heterocyclic compounds consisting of a five-membered C3NS ring. The term usually refers to a family of drugs used in the treatment of diabetes mellitus type 2 that were introduced in the late 1990s."@en . . . . . "\u0422\u0438\u0430\u0437\u043E\u043B\u0438\u0434\u0438\u043D\u0434\u0438\u043E\u043D\u044B"@ru . "Las tiazolidinedionas (TZD) son una clase de medicamentos introducidos a finales de los a\u00F1os 1990 como terapia para la diabetes mellitus tipo 2 y otras enfermedades relacionadas. Las tiazolidinedionas mejoran la sensibilidad de los tejidos blancos a la insulina por actuar como agonistas selectivos de receptores de la insulina localizados en el n\u00FAcleo celular."@es . . . . . . . . "\u0422\u0456\u0430\u0437\u043E\u043B\u0456\u0434\u0438\u043D\u0435\u0434\u0456\u043E\u043D\u0438 (\u0430\u043D\u0433\u043B. Thiazolidinedione), \u044F\u043A\u0456 \u043F\u043E\u0437\u043D\u0430\u0447\u0430\u044E\u0442\u044C\u0441\u044F \u0430\u0431\u0440\u0435\u0432\u0456\u0430\u0442\u0443\u0440\u043E\u044E TZD, \u0432\u0456\u0434\u043E\u043C\u0456 \u0442\u0430\u043A\u043E\u0436 \u044F\u043A \u0433\u043B\u0456\u0442\u0430\u0437\u043E\u043D\u0438 \u043F\u0456\u0441\u043B\u044F \u0440\u043E\u0437\u0440\u043E\u0431\u043A\u0438 \u043F\u0435\u0440\u0448\u043E\u0433\u043E \u043F\u0440\u0435\u043F\u0430\u0440\u0430\u0442\u0443 \u0433\u0440\u0443\u043F\u0438 \u2014 \u0446\u0435 \u043A\u043B\u0430\u0441 \u0433\u0435\u0442\u0435\u0440\u043E\u0446\u0438\u043A\u043B\u0456\u0447\u043D\u0438\u0445 \u0441\u043F\u043E\u043B\u0443\u043A, \u0434\u043E \u0441\u043A\u043B\u0430\u0434\u0443 \u044F\u043A\u0438\u0445 \u0432\u0445\u043E\u0434\u0438\u0442\u044C \u043F'\u044F\u0442\u0438\u0447\u043B\u0435\u043D\u043D\u0435 \u043A\u0456\u043B\u044C\u0446\u0435 C3NS. \u0426\u044F \u043D\u0430\u0437\u0432\u0430 \u0437\u0430\u0441\u0442\u043E\u0441\u043E\u0432\u0443\u0454\u0442\u044C\u0441\u044F \u0434\u043B\u044F \u0433\u0440\u0443\u043F\u0438 \u043B\u0456\u043A\u0430\u0440\u0441\u044C\u043A\u0438\u0445 \u0437\u0430\u0441\u043E\u0431\u0456\u0432, \u044F\u043A\u0456 \u0437\u0430\u0441\u0442\u043E\u0441\u043E\u0432\u0443\u044E\u0442\u044C\u0441\u044F \u0434\u043B\u044F \u043B\u0456\u043A\u0443\u0432\u0430\u043D\u043D\u044F \u0446\u0443\u043A\u0440\u043E\u0432\u043E\u0433\u043E \u0434\u0456\u0430\u0431\u0435\u0442\u0443 \u0406\u0406 \u0442\u0438\u043F\u0443, \u0442\u0430 \u0437\u0430\u0441\u0442\u043E\u0441\u043E\u0432\u0443\u044E\u0442\u044C\u0441\u044F \u0432 \u043A\u043B\u0456\u043D\u0456\u0447\u043D\u0456\u0439 \u043F\u0440\u0430\u043A\u0442\u0438\u0446\u0456 \u0437 90-\u0445 \u0440\u043E\u043A\u0456\u0432 \u0425\u0425 \u0441\u0442\u043E\u043B\u0456\u0442\u0442\u044F."@uk . . . "\u062B\u064A\u0627\u0632\u0648\u0644\u064A\u062F\u064A\u0646\u062F\u064A\u0648\u0646"@ar . .