About: Use of albumin quotient and IgG index to differentiate blood‐ vs brain‐derived proteins in the cerebrospinal fluid of cats with feline infectious peritonitis

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About: Use of albumin quotient and IgG index to differentiate blood‐ vs brain‐derived proteins in the cerebrospinal fluid of cats with feline infectious peritonitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Use of albumin quotient and IgG index to differentiate blood‐ vs brain‐derived proteins in the cerebrospinal fluid of cats with feline infectious peritonitis
Creator	Hartmann, Katrin Matiasek, Kaspar Boettcher, Irene Fischer, Andrea Hirschvogel, Katrin Kuntz, Anne Steinberg, Tanja
Source	Medline; PMC
abstract	Background: Inflammation of the central nervous system (CNS) is a frequent condition in cats but etiology often remains unsolved. Routine cerebrospinal fluid (CSF) analysis can be extended through the calculation of the albumin quotient (Q (alb)), a marker of the integrity of the blood–brain barrier (BBB), and IgG index, an estimate of intrathecal IgG synthesis. Objectives: The purpose of this study was to validate nephelometric methods for CSF protein analysis, and to use the Q (alb) and IgG index to discriminate blood‐ and brain‐derived immunoglobulin fractions in cats with feline infectious peritonitis (FIP). Methods: Cats presented to our clinic between 2001 and 2005 were included in the study based on clinical and laboratory data and histopathologic findings at necropsy. Cats were grouped as having nonneurologic disease (controls; n=37), brain tumors (n=8), FIP involving the CNS (n=12), and extraneural FIP (n=12). CSF‐total protein (TP) was measured and albumin and IgG concentrations were measured in paired CSF/serum samples; Q (alb) and IgG index were calculated. Intraassay and interassay precision of the nephelometric assays were determined using pooled samples. Results: Coefficients of variation for the nephelometric assays ranged from 2.7% to 7.2%. In control cats, CSF‐TP concentration ranged from 0.06 to 0.36 g/L, Q (alb) ranged from 0.6 to 5.7 × 10(−3), and IgG index ranged from 0.3 to 0.6. Q (alb) and IgG index were significantly higher in cats with brain tumors and cats with CNS‐FIP compared with other groups. Compared with control cats, pleocytosis was evident in 8 of 12 (67%) cats and CSF‐TP was increased in 3 of 12 (25%) cats with CNS‐FIP. Conclusion: Nephelometry is a reliable method for measurement of CSF protein, albumin, and IgG in cats. The Q (alb) and IgG index did not identify a CSF protein pattern specific for BBB dysfunction or intrathecal IgG synthesis in cats with CNS‐FIP.
has issue date	2008-06-02(xsd:dateTime)
bibo:doi	10.1111/j.1939-165x.2008.00028.x
bibo:pmid	18533921
has license	no-cc
sha1sum (hex)	37f1e02013ec0f53bde8bcb3fc78a04df1cdf811
schema:url	https://doi.org/10.1111/j.1939-165x.2008.00028.x
resource representing a document's title	Use of albumin quotient and IgG index to differentiate blood‐ vs brain‐derived proteins in the cerebrospinal fluid of cats with feline infectious peritonitis
has PubMed Central identifier	PMC7169305
has PubMed identifier	18533921
schema:publication	Vet Clin Pathol
resource representing a document's body	covid:37f1e02013ec0f53bde8bcb3fc78a04df1cdf811#body_text
is schema:about of	named entity 'cats' named entity 'nephelometric' named entity 'nephelometric' named entity 'measured' named entity 'The Q' named entity 'assays' named entity 'The' named entity 'presented' named entity 'assays' named entity 'cats' named entity 'samples' named entity 'cerebrospinal fluid' named entity 'BBB' named entity 'cats' named entity 'compared' named entity 'concentration' named entity 'Nephelometry' named entity 'ranged' named entity 'CSF' named entity 'quotient' named entity 'validate' named entity 'FIP' named entity 'serum samples' named entity 'CNS' named entity 'IgG' named entity 'nephelometric assays' named entity 'nephelometric assays' named entity 'albumin' named entity 'CNS' named entity 'IgG index' named entity 'protein analysis' named entity 'IgG index' named entity 'IgG' named entity 'CNS' named entity 'total protein' named entity 'blood-brain barrier' named entity 'feline infectious peritonitis' named entity 'cats' named entity 'specific' named entity 'CSF analysis' named entity 'FIP' named entity 'CSF analysis' named entity 'Montgomery, TX' named entity 'Germany' named entity 'Coefficients of variation' named entity 'neutrophils' named entity 'British Shorthair' named entity 'IgG' named entity 'leukocytes' named entity 'FIP' named entity 'B-cell lymphoma' named entity 'Germany' named entity 'H&E' named entity 'IgG' named entity 'IgG index' named entity 'albumin' named entity 'passive transfer' named entity 'Grenzach' named entity 'linear function' named entity 'IgG index' named entity 'FIP' named entity 'Darmstadt' named entity 'positively correlated' named entity 'FIP' named entity 'CNS' named entity 'FIP' named entity 'CNS' named entity 'FIP' named entity 'CSF analysis' named entity 'pancreas' named entity 'plasma' named entity 'formalin' named entity 'antibody' named entity 'necrotizing' named entity 'CNS'

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