About: Regulatory T Cells in Arterivirus and Coronavirus Infections: Do They Protect Against Disease or Enhance it?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Regulatory T Cells in Arterivirus and Coronavirus Infections: Do They Protect Against Disease or Enhance it?
Creator	Leroith, Tanya Todd, S Cecere, Thomas
Source	Medline; PMC
abstract	Regulatory T cells (T(regs)) are a subset of T cells that are responsible for maintaining peripheral immune tolerance and homeostasis. The hallmark of T(regs) is the expression of the forkhead box P3 (FoxP3) transcription factor. Natural regulatory T cells (nT(regs)) are a distinct population of T cells that express CD4 and FoxP3. nTregs develop in the thymus and function in maintaining peripheral immune tolerance. Other CD4(+), CD4(-)CD8(-), and CD8(+)CD28(-) T cells can be induced to acquire regulatory function by antigenic stimulation, depending on the cytokine milieu. Inducible (or adaptive) T(regs) frequently express high levels of the interleukin 2 receptor (CD25). Atypical T(regs) express FoxP3 and CD4 but have no surface expression of CD25. Type 1 regulatory T cells (Tr1 cells) produce IL-10, while T helper 3 cells (Th3) produce TGF-β. The function of inducible T(regs) is presumably to maintain immune homeostasis, especially in the context of chronic inflammation or infection. Induction of T(regs) in coronaviral infections protects against the more severe forms of the disease attributable to the host response. However, arteriviruses have exploited these T cell subsets as a means to dampen the immune response allowing for viral persistence. T(reg) induction or activation in the pathogenesis of disease has been described in both porcine reproductive and respiratory syndrome virus, lactate dehydrogenase elevating virus, and mouse hepatitis virus. This review discusses the development and biology of regulatory T cells in the context of arteriviral and coronaviral infection.
has issue date	2012-05-15(xsd:dateTime)
bibo:doi	10.3390/v4050833
bibo:pmid	22754651
has license	cc-by
sha1sum (hex)	47ee3efc99d4ed2a08a7c8e677adfd98425dade6
schema:url	https://doi.org/10.3390/v4050833
resource representing a document's title	Regulatory T Cells in Arterivirus and Coronavirus Infections: Do They Protect Against Disease or Enhance it?
has PubMed Central identifier	PMC3386620
has PubMed identifier	22754651
schema:publication	Viruses
resource representing a document's body	covid:47ee3efc99d4ed2a08a7c8e677adfd98425dade6#body_text
is schema:about of	named entity 'T REG' named entity 'THESE' named entity 'BUT' named entity 'BIOLOGY' named entity 'FUNCTION' named entity 'POPULATION' named entity 'INDUCTION' named entity 'CD28' named entity 'IMMUNE RESPONSE' named entity 'IMMUNE' named entity 'CELLS' named entity 'RESPONSIBLE' named entity 'ADAPTIVE' named entity 'PERIPHERAL' named entity 'EXPRESS' named entity 'ATTRIBUTABLE' named entity 'VIRAL PERSISTENCE' named entity 'CD8' named entity 'INFECTIONS' named entity 'HAVE' named entity 'FORMS' named entity 'SURFACE' named entity 'LACTATE DEHYDROGENASE' named entity 'LEVELS' named entity 'ARTERIVIRUS' named entity 'function' named entity 'function' named entity 'regs' named entity 'virus' named entity 'population' named entity 'DISEASE' named entity 'T HELPER' named entity 'TRANSCRIPTION FACTOR' named entity 'ARTERIVIRUSES' named entity 'THYMUS' named entity 'MOUSE HEPATITIS VIRUS' named entity 'CD4' named entity 'MAINTAINING' named entity 'MEANS' named entity 'CYTOKINE ' named entity 'CONTEXT' named entity 'TYPE 1' named entity 'ELEVATING' named entity 'NATURAL' named entity 'CD25' named entity 'T CELLS' named entity 'ALLOWING' named entity 'REGULATORY T CELLS' named entity 'SUBSET' named entity 'DISEASE' named entity 'ACQUIRE' named entity 'INFECTION' named entity 'REVIEW' named entity 'DEVELOPMENT' named entity 'EXPRESSION' named entity 'FREQUENTLY' named entity 'NTREGS' named entity 'DESCRIBED' named entity 'HOST RESPONSE' named entity 'FORKHEAD BOX P3' named entity 'CORONAVIRUS INFECTIONS' named entity 'ENHANCE' named entity 'REGULATORY T CELLS' named entity 'PRODUCE' named entity 'HIGH' named entity 'VIRUS' named entity 'IMMUNE TOLERANCE' named entity 'T CELL SUBSETS' named entity 'INTERLEUKIN 2 RECEPTOR' named entity 'HOMEOSTASIS' named entity 'STIMULATION' named entity 'CHRONIC INFLAMMATION' named entity 'FOXP3' named entity 'ATYPICAL' named entity 'ACTIVATION' named entity 'TO MAINTAIN' named entity 'SEVERE' named entity 'IL-10' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS'

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