About: Evaluation of antiviral activity of Bacillus licheniformis-fermented products against porcine epidemic diarrhea virus

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About: Evaluation of antiviral activity of Bacillus licheniformis-fermented products against porcine epidemic diarrhea virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of antiviral activity of Bacillus licheniformis-fermented products against porcine epidemic diarrhea virus
Creator	Chang, Hui-Wen Jeng, Chian-Ren Chang, Chia-Yu Chang, Yen-Chen Peng, Ju-Yi Tsai, Pei-Shiue Cheng, Yeong-Hsiang Horng, Yi-Bing Wu, Ching-Ho
Source	Medline; PMC
abstract	Bacillus licheniformis (B. licheniformis) is commonly used as probiotic and its secondary metabolites are attractive anti-microbial candidate. In the present study, we aimed to evaluate the antiviral activity of crude extracts from B. licheniformis against porcine epidemic diarrhea virus (PEDV), a highly contagious enveloped porcine virus that has caused great economic loss in pigs. In vivo, PEDV-infected piglets supplemented with air-dried solid state fermentative cultivate containing B. licheniformis-fermented products (BLFP) showed milder clinical symptoms and decreased viral shedding. Importantly, no significant systemic pathological lesions and no reduction in average daily gain were noted in pigs supplemented with the BLFP, which suggests that it is safe for use in pigs. In vitro experiments revealed that while B. licheniformis crude extracts exhibited no toxicity in Vero cells, co-cultivation of B. licheniformis crude extracts with PEDV significantly reduced viral infection and replication. Summarized current results suggest that the B. licheniformis-fermented products could be a novel candidate food additive for reducing the impact of PED on the swine industry.
has issue date	2019-12-03(xsd:dateTime)
bibo:doi	10.1186/s13568-019-0916-0
bibo:pmid	31797149
has license	cc-by
sha1sum (hex)	f635dd0f13ee3859c7e4b653398c9b9dba9895d8
schema:url	https://doi.org/10.1186/s13568-019-0916-0
resource representing a document's title	Evaluation of antiviral activity of Bacillus licheniformis-fermented products against porcine epidemic diarrhea virus
has PubMed Central identifier	PMC6890879
has PubMed identifier	31797149
schema:publication	AMB Express
resource representing a document's body	covid:f635dd0f13ee3859c7e4b653398c9b9dba9895d8#body_text
is schema:about of	named entity 'EVALUATION' named entity 'study' named entity 'lesions' named entity 'medium' named entity 'In vitro' named entity 'Bacillus' named entity 'Bacillus' named entity 'FERMENTED' named entity 'CHANGES' named entity 'REPRODUCTION' named entity 'NOTED' named entity 'CURRENT' named entity 'REVEALED' named entity 'CONTAINING' named entity 'PROVIDED' named entity 'AVERAGE DAILY GAIN' named entity 'ITS' named entity 'GREAT' named entity 'SOLID STATE' named entity 'COULD BE' named entity 'DISTRIBUTION' named entity 'MEDIUM' named entity 'INDUSTRY' named entity 'NOVEL' named entity 'ORIGINAL' named entity 'EXPERIMENTS' named entity 'PROVIDE' named entity 'CREDIT' named entity 'LESIONS' named entity 'USE' named entity 'PRESENT' named entity 'DRIED' named entity 'MICROBIAL' named entity 'SECONDARY METABOLITES' named entity 'UNRESTRICTED' named entity 'PED' named entity 'PRODUCTS' named entity 'CAUSED' named entity 'PERMITS' named entity 'RESULTS' named entity 'VIRUS' named entity 'SAFE' named entity 'REPLICATION' named entity 'NO REDUCTION' named entity 'AIR' named entity 'STUDY' named entity 'SIGNIFICANT' named entity 'SUGGEST' named entity 'APPROPRIATE' named entity 'PORCINE' named entity 'FOOD ADDITIVE' named entity 'PATHOLOGICAL' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'FERMENTED' named entity '28S' named entity 'LINK' named entity 'EVALUATE' named entity 'ATTRACTIVE' named entity 'REDUCING' named entity 'ANTIVIRAL ACTIVITY' named entity 'SOURCE' named entity 'CREATIVE COMMONS' named entity 'BACILLUS LICHENIFORMIS' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'VIRAL INFECTION' named entity 'INFECTED' named entity 'TOXICITY' named entity 'SWINE' named entity 'PROBIOTIC' named entity 'PIGS' named entity 'IMPACT' named entity 'CULTIVATION' named entity 'CLINICAL SYMPTOMS'

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