About: Cerlapirdine

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About: Cerlapirdine Goto Sponge NotDistinct Permalink

An Entity of Type : yago:Substance100019613, within Data Space : wasabi.inria.fr associated with source document(s)

Cerlapirdine (USAN; SAM-531, WAY-262,531, PF-05212365) is a drug which was under development by Wyeth/Pfizer for the treatment of cognitive disorders associated with Alzheimer's disease and schizophrenia. In a phase II clinical trial it demonstrated a trend toward efficacy along with a good side effect profile and no incidence of serious adverse events, but no further development has occurred since 2011. It exerts its effects by acting as a selective 5-HT6 receptor antagonist.

Attributes	Values
type	Thing yago:Abstraction100002137 yago:PhysicalEntity100001930 yago:Part113809207 yago:Relation100031921 drug chemical substance drug Chemical object yago:AliphaticCompound114601294 yago:Amine114739004 yago:MethaneSeries114951377 yago:WikicatAmines yago:Chemical114806838 yago:Compound114818238 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Substance100019613
label	Cerlapirdine
comment	Cerlapirdine (USAN; SAM-531, WAY-262,531, PF-05212365) is a drug which was under development by Wyeth/Pfizer for the treatment of cognitive disorders associated with Alzheimer's disease and schizophrenia. In a phase II clinical trial it demonstrated a trend toward efficacy along with a good side effect profile and no incidence of serious adverse events, but no further development has occurred since 2011. It exerts its effects by acting as a selective 5-HT6 receptor antagonist.
sameAs	Cerlapirdine Cerlapirdine Cerlapirdine Cerlapirdine Cerlapirdine Cerlapirdine Cerlapirdine Cerlapirdine Cerlapirdine
topic	dbr:5-HT6_receptor dbr:Idalopirdine dbr:Latrepirdine dbr:SAM-531 dbr:C22H23N3O3S dbr:PF-05212365 dbr:WAY-262,531 dbr:WAY-262531 wikipedia-en:Cerlapirdine dbr:Cerlapirdine#this
depiction
described by	https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/class/yago/Compound114818238 https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/class/yago/Chemical114806838 https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Drug https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/class/yago/OrganicCompound114727670
dbp:kegg	D10099
dbp:legalStatus	Investigational
Subject	Abandoned drugs dbc:Dimethylamino_compounds dbc:1-Naphthyl_compounds
dbo:wikiPageID	33530675(xsd:integer)
dbo:wikiPageRevisionID	1120768438(xsd:integer)
dbo:wikiPageWikiLink	Binding selectivity drug Schizophrenia Phases of clinical research Pfizer dbr:5-HT6_receptor Alzheimer's disease Drug development Receptor antagonist Hydrochloride dbr:United_States_Adopted_Name Side effect Wyeth Cognitive disorder Clinical trial Abandoned drugs dbr:Idalopirdine dbr:Latrepirdine dbc:Dimethylamino_compounds dbc:1-Naphthyl_compounds
is primary topic of	wikipedia-en:Cerlapirdine
wasDerivedFrom	wikipedia-en:Cerlapirdine?oldid=1120768438&ns=0
http://purl.org/li...ics/gold/hypernym	drug
dbo:abstract	Cerlapirdine (USAN; SAM-531, WAY-262,531, PF-05212365) is a drug which was under development by Wyeth/Pfizer for the treatment of cognitive disorders associated with Alzheimer's disease and schizophrenia. In a phase II clinical trial it demonstrated a trend toward efficacy along with a good side effect profile and no incidence of serious adverse events, but no further development has occurred since 2011. It exerts its effects by acting as a selective 5-HT6 receptor antagonist.
dbo:thumbnail	wiki-commons:Special:FilePath/Cerlapirdine.svg?width=300
dbp:c	22(xsd:integer)
dbp:h	23(xsd:integer)
dbp:n	3(xsd:integer)
dbp:s	1(xsd:integer)
dbp:atcPrefix	none
dbp:casSupplemental	925447(xsd:integer)
dbp:casNumber	925448(xsd:integer)
dbp:chembl	2103880(xsd:integer)
dbp:chemspiderid	17231095(xsd:integer)
dbp:iupacName	N,N-dimethyl-3-[oxy]propan-1-amine
dbp:o	3(xsd:integer)
dbp:pubchem	16071605(xsd:integer)
dbp:smiles	CNCCCOc4ccc3[nH]ncc3c4
dbp:stdinchi	1(xsd:integer)
dbp:stdinchikey	NXQGEDVQXVTCDA-UHFFFAOYSA-N
dbp:unii	EK40PJ0V49
dbo:casNumber	925447-04-7 (hydrochloride) 925448-93-7
dbo:chEMBL	2103880
dbo:fdaUniiCode	EK40PJ0V49
dbo:kegg	D10099
dbo:pubchem	16071605
dbo:wikiPageLength	2677(xsd:integer)

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