About: Estrone phosphate

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An Entity of Type : dul:ChemicalObject, within Data Space : wasabi.inria.fr associated with source document(s)

Estrone phosphate (E1P), or estrone 3-phosphate, is an estrogen and steroid sulfatase inhibitor which was never marketed. It has similar affinity for steroid sulfatase as estrone sulfate and acts as a competitive inhibitor of the enzyme. In contrast to estrone sulfate however, it is not hydrolyzed by steroid sulfatase and is instead metabolized by phosphatases.

Attributes	Values
type	Thing drug chemical substance drug Chemical object
label	Estrone phosphate
comment	Estrone phosphate (E1P), or estrone 3-phosphate, is an estrogen and steroid sulfatase inhibitor which was never marketed. It has similar affinity for steroid sulfatase as estrone sulfate and acts as a competitive inhibitor of the enzyme. In contrast to estrone sulfate however, it is not hydrolyzed by steroid sulfatase and is instead metabolized by phosphatases.
sameAs	Estrone phosphate Estrone phosphate Estrone phosphate
topic	dbr:Oestrone_phosphate dbr:List_of_estrogen_esters wikipedia-en:Estrone_phosphate dbr:Estrone_phosphate#this
depiction
described by	proxy:entity/http/dbpedia.org/resource/Metabolism https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Metabolism https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Category:Prodrugs https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Enzyme https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Enzyme_inhibitor https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Template:Fdacite https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Estriol_phosphate
subject	Synthetic estrogens dbc:Phosphate_esters dbc:Steroid_sulfatase_inhibitors Abandoned drugs Prodrugs dbc:Estrone_esters
dbo:wikiPageID	63468037(xsd:integer)
Wikipage revision ID	1120787475(xsd:integer)
dbo:wikiPageWikiLink	Phosphatase metabolism dbr:Estradiol_phosphate Estriol phosphate dbr:Estrone_sulfate dbr:Steroid_sulfatase_inhibitor Synthetic estrogens Competitive inhibition enzyme enzyme inhibitor Steroid sulfatase dbc:Phosphate_esters dbc:Steroid_sulfatase_inhibitors Hydrolysis Abandoned drugs dbr:Estrogen_(medication) dbr:Affinity_(pharmacology) Prodrugs dbc:Estrone_esters dbr:List_of_estrogen_esters
is primary topic of	wikipedia-en:Estrone_phosphate
wasDerivedFrom	wikipedia-en:Estrone_phosphate?oldid=1120787475&ns=0
dbo:abstract	Estrone phosphate (E1P), or estrone 3-phosphate, is an estrogen and steroid sulfatase inhibitor which was never marketed. It has similar affinity for steroid sulfatase as estrone sulfate and acts as a competitive inhibitor of the enzyme. In contrast to estrone sulfate however, it is not hydrolyzed by steroid sulfatase and is instead metabolized by phosphatases.
dbo:thumbnail	wiki-commons:Special:FilePath/estrone_phosphate.svg?width=300
dbp:c	18(xsd:integer)
dbp:class	dbr:Steroid_sulfatase_inhibitor dbr:Estrogen_(medication)
dbp:h	23(xsd:integer)
dbp:p	1(xsd:integer)
dbp:casNumber	1240-03-05(xsd:dateTime)
dbp:chembl	1232577(xsd:integer)
dbp:chemspiderid	393068(xsd:integer)
dbp:iupacName	[-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] dihydrogen phosphate
dbp:o	5(xsd:integer)
dbp:pubchem	445419(xsd:integer)
dbp:smiles	C[C@]12CC[C@H]3[C@H]CCC4=C3C=CCOPO
dbp:stdinchi	1(xsd:integer)
dbp:stdinchikey	XYNRXDLLYXFCRS-CBZIJGRNSA-N
dbp:synonyms	Estrone 3-phosphate; E1P; O3-Phosphonoestrone; 17-Oxoestra-1,3,5-trien-3-yl dihydrogen phosphate
dbp:unii	52(xsd:integer)
dbo:casNumber	1240-03-5
dbo:chEMBL	1232577
dbo:fdaUniiCode	52ZYE9C9X9
PubChem	445419
dbo:class	dbr:Steroid_sulfatase_inhibitor dbr:Estrogen_(medication)
dbo:wikiPageLength	4122(xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:Reflist dbt:Fdacite dbt:Genito-urinary-drug-stub dbt:Cascite
is sameAs of	Estrone phosphate
is topic of	metabolism Estriol phosphate enzyme enzyme inhibitor Prodrugs dbt:Fdacite
is dbo:wikiPageWikiLink of	dbr:Oestrone_phosphate dbr:List_of_estrogen_esters
is Wikipage redirect of	dbr:Oestrone_phosphate
is topic of	wikipedia-en:Estrone_phosphate
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/dbpedia.org/resource/Estrone_phosphate

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