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Lymphangiogenesis is the formation of lymphatic vessels from pre-existing lymphatic vessels in a method believed to be similar to angiogenesis (blood vessel development). Lymphangiogenesis plays an important physiological role in homeostasis, metabolism and immunity. Impaired or excessive lymphatic vessel formation has been implicated in a number of pathological conditions including neoplasm metastasis, oedema, rheumatoid arthritis, psoriasis, lymphangiomatosis and impaired wound healing.

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  • Lymphangiogenese
  • Lymphangiogenesis
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  • Lymphangiogenese ist das Wachstum neuer Lymphgefäße von bereits existierenden Gefäßen ähnlich dem Prozess der Angiogenese (Wachstum der Blutgefäße). Davon abzugrenzen ist der Prozess der Lymphvaskulogenese (der de-novo-Bildung von lymphatischen Strukturen aus Vorläuferzellen).
  • Lymphangiogenesis is the formation of lymphatic vessels from pre-existing lymphatic vessels in a method believed to be similar to angiogenesis (blood vessel development). Lymphangiogenesis plays an important physiological role in homeostasis, metabolism and immunity. Impaired or excessive lymphatic vessel formation has been implicated in a number of pathological conditions including neoplasm metastasis, oedema, rheumatoid arthritis, psoriasis, lymphangiomatosis and impaired wound healing.
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  • Lymphangiogenesis
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  • Lymphangiogenesis
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  • Lymphangiogenesis is the formation of lymphatic vessels from pre-existing lymphatic vessels in a method believed to be similar to angiogenesis (blood vessel development). Lymphangiogenesis plays an important physiological role in homeostasis, metabolism and immunity. Impaired or excessive lymphatic vessel formation has been implicated in a number of pathological conditions including neoplasm metastasis, oedema, rheumatoid arthritis, psoriasis, lymphangiomatosis and impaired wound healing. The role of the lymphatic system in these diseases has received renewed interest largely due to the discovery of (LEC)-specific markers such as podoplanin, LYVE-1, PROX1, desmoplakin and VEGF-C receptor VEGFR-3. These specific markers have enabled insights into functional and molecular lymphatic biology. There are several known pro-lymphangiogenesis inducers such as VEGF-C, hyaluronic acid and ephrin-B2.
  • Lymphangiogenese ist das Wachstum neuer Lymphgefäße von bereits existierenden Gefäßen ähnlich dem Prozess der Angiogenese (Wachstum der Blutgefäße). Davon abzugrenzen ist der Prozess der Lymphvaskulogenese (der de-novo-Bildung von lymphatischen Strukturen aus Vorläuferzellen). Lymphangiogenese spielt eine wichtige physiologische Rolle in der Homöostase, im Stoffwechsel und der Immunität. Die unzureichende oder vermehrte Bildung von Lymphgefäßen ist charakteristisch für eine Reihe von Krankheiten, so z. B. für Tumor-Metastasierung, Lymphödem, Lipödem, Rheumatoide Arthritis, Psoriasis, Lymphangiomatosis und verzögerte Wundheilung. Die Rolle des Lymphsystems in diesen Krankheiten hat das Interesse an der Lymphangiogenese erneut geweckt, nicht zuletzt aufgrund der Entdeckung von Markern, die spezifisch für lymphatische Endothelzellen sind, wie dem Rezeptor des Vaskulären Endothelzell-Wachstumsfaktor C VEGF-C, Podoplanin, LYVE1, und Desmoplakin. Diese spezifischen Marker ermöglichten neue Erkenntnisse über die Funktion, Struktur und molekularbiologischen Grundlagen des Lymphsystems. Mehrere Faktoren sind bekannt, die die Lymphangiogenese anregen, unter anderen VEGF-C, Hyaluronsäure and .
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