About: MUTYH

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An Entity of Type : yago:Sequence108459252, within Data Space : wasabi.inria.fr associated with source document(s)

MUTYH (mutY DNA glycosylase) is a human gene that encodes a DNA glycosylase, MUTYH glycosylase. It is involved in oxidative DNA damage repair and is part of the base excision repair pathway. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a common form of oxidative DNA damage.

Attributes	Values
type	Thing biomolecule gene gene yago:Abstraction100002137 yago:Group100031264 yago:PhysicalEntity100001930 yago:Part113809207 yago:Relation100031921 Biomolecule protein HumanGene dbo:Gene yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Protein114728724 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteins yago:Arrangement107938773 yago:Ordering108456993 yago:Series108457976 yago:Gene105436752 yago:WikicatHumanGenes yago:WikicatGenesOnChromosome1 yago:Sequence108459252
label	MUTYH MUTYH MUTYH
comment	MUTYH (E. coli MutY homolog) – gen kodujący glikozylazę DNA zaangażowaną w proces naprawy uszkodzeń oksydacyjnych DNA. Ten typ naprawy określa się jako naprawę przez wycinanie zasady. Białko MUTYH lokalizuje się w jądrze komórkowym i mitochondriach. Gen MUTYH znajduje się w locus 1p34.3-32.1. MUTYH (англ. MutY DNA glycosylase) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 546 амінокислот, а молекулярна маса — 60 069. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин MUTYH (mutY DNA glycosylase) is a human gene that encodes a DNA glycosylase, MUTYH glycosylase. It is involved in oxidative DNA damage repair and is part of the base excision repair pathway. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a common form of oxidative DNA damage.
sameAs	MUTYH MUTYH MUTYH MUTYH MUTYH MUTYH MUTYH MUTYH MUTYH MUTYH MUTYH
topic	Base excision repair dbr:Cancer_syndrome Familial adenomatous polyposis dbr:APEX1 dbr:ETS1 Proliferating cell nuclear antigen dbr:MUTYH-associated_polyposis dbr:Chromosome_1 dbr:Cronkhite–Canada_syndrome dbr:Replication_protein_A1 dbr:13-Hydroxyoctadecadienoic_acid dbr:Attenuated_familial_adenomatous_polyposis DNA glycosylase dbr:DNA_repair-deficiency_disorder Adenomatous polyposis coli dbr:Mutational_signatures dbr:Serrated_polyposis_syndrome dbr:MUTYH_(gene) dbr:MYH dbr:Myh List of OMIM disorder codes dbr:Werner_syndrome_helicase dbr:List_of_human_protein-coding_genes_3 wikipedia-en:MUTYH dbr:MUTYH#this
described by	https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/class/yago/Compound114818238 proxy:entity/http/dbpedia.org/resource/Amino_acid https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Template:Infobox_gene https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/class/yago/WikicatHumanGenes https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Gene https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/class/yago/OrganicCompound114727670
Subject	Human genes
dbo:wikiPageID	3568274(xsd:integer)
dbo:wikiPageRevisionID	1119153626(xsd:integer)
dbo:wikiPageWikiLink	Adenine Cytosine Base excision repair dbr:Protein-protein_interaction Cysteine Glycine dbr:Ethinylestradiol Oxoguanine glycosylase dbr:Gastric_cancer dbr:APC_(gene) dbr:AP_endonuclease amino acid Caucasian race DNA replication gene Guanine PARP1

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