About: NK2 homeobox 1

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An Entity of Type : yago:Origin107323922, within Data Space : wasabi.inria.fr associated with source document(s)

NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene.

Attributes	Values
type	Thing biomolecule protein gene yago:Abstraction100002137 yago:Event100029378 yago:PhysicalEntity100001930 yago:PsychologicalFeature100023100 yago:YagoPermanentlyLocatedEntity yago:Part113809207 yago:Relation100031921 Biomolecule protein HumanGene dbo:Gene yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Protein114728724 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteins yago:Cause107326557 yago:Factor107327805 yago:WikicatTranscriptionFactors yago:Happening107283608 yago:Beginning107290905 yago:Origin107323922
label	NK2 homeobox 1 Thyroid Transcription Factor -1 Thyroidaler Transkriptionsfaktor 1 Factor de transcripción tiroidea 1 (TTF-1) Fator de transcrição da tireoide 1 NKX2-1
comment	Der Thyroidale Transkriptionsfaktor 1, abgekürzt TTF1, ist ein Protein, das als Transkriptionsfaktor unter anderem die Transkription von bestimmten Genen in der Schilddrüse kontrolliert. TTF1 wird vom Homöobox-Gen NK2 homeobox 1, abgekürzt NKX2-1, codiert und ist nicht nur im Menschen, sondern auch in einer Vielzahl von Tierarten nachgewiesen worden. O NK2 homeobox 1 (NKX2-1), também conhecido como fator de transcrição da tireoide 1 (TTF-1, do inglês "thyroid transcription factor 1"), é uma proteína que, em humanos, é codificada pelo gene NKX2-1. O fator de transcrição da tireoide 1 regula a transcrição de genes específicos da tireoide, do pulmão e do diencéfalo. Ele é utilizado na anatomia patológica como um marcador para determinar se um tumor teve origem no pulmão ou na tireoide. El factor de transcripción tiroidea 1 (TTF-1), también conocido como NK2 homeobox 1 (NKX2-1), es una proteína qué en los humanos está codificada por el gen NKX2-1. c e Thyroid transcription factor-1 (TTF-1) est une protéine qui régule la transcription de gènes spécifiques à la thyroïde, au poumon et au diencéphale. Elle est aussi connue comme thyroid specific enhancer binding protein. Son gène est le NKX2-1 situé sur le chromosome 14 humain. On s'en sert en anatomo-pathologie comme marqueur pour déterminer si une tumeur provient des poumons ou de la thyroïde. NKX2-1 (англ. NK2 homeobox 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 14-ї хромосоми. Довжина поліпептидного ланцюга білка становить 371 амінокислот, а молекулярна маса — 38 596. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene.
differentFrom	RNA polymerase I dbr:Transcription_termination_factor dbr:TTF1
sameAs	NKX2-1 NKX2-1 NKX2-1 NKX2-1 NKX2-1 NKX2-1 NKX2-1 NKX2-1 NKX2-1 NKX2-1 NKX2-1 NKX2-1 NKX2-1
topic	Hypothyroidism Neuroendocrine differentiation dbr:Lung_bud dbr:Tracheal_agenesis PITX2 Homeobox dbr:Development_of_the_cerebral_cortex Calreticulin dbr:Benign_hereditary_chorea dbr:Large-cell_lung_carcinoma_with_rhabdoid_phenotype dbr:TITF1 dbr:TITF1_(gene) dbr:TTF-1 dbr:NKX-homeodomain_factor dbr:NKX2-1 dbr:NKX2-1_(gene) dbr:Inversion_(evolutionary_biology) dbr:PAX8 dbr:PAX9 dbr:Thyroid_transcription_factor-1 dbr:Thyroid_transcription_factor_1 wikipedia-en:NK2_homeobox_1 dbr:NK2_homeobox_1#this dbr:Shioko_Kimura
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