About: Nav1.8

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An Entity of Type : yago:WikicatIonChannels, within Data Space : wasabi.inria.fr associated with source document(s)

Nav1.8 is a sodium ion channel subtype that in humans is encoded by the SCN10A gene. Nav1.8-containing channels are tetrodotoxin (TTX)-resistant voltage-gated channels. Nav1.8 is expressed specifically in the dorsal root ganglion (DRG), in unmyelinated, small-diameter sensory neurons called C-fibres, and is involved in nociception. C-fibres can be activated by noxious thermal or mechanical stimuli and thus can carry pain messages.

Attributes	Values
type	Thing biomolecule gene yago:Abstraction100002137 yago:Act100030358 yago:Event100029378 yago:PsychologicalFeature100023100 yago:YagoPermanentlyLocatedEntity agent organisation yago:Channel106259898 Biomolecule broadcaster television station HumanGene dbo:Gene Channel yago:Communication106252138 yago:Transmission106251781 yago:WikicatIonChannels
label	Nav1.8 SCN10A SCN10A SCN10A
comment	Le SCN10A (« Sodium channel de type 10 avec sous-unité alpha » ou Nav1.8 est une protéine de type canal sodique dont le gène est SCN10A situé sur le chromosome 3 humain. SCN10A, em inglês Sodium channel, voltage gated, type X, alpha subunit (canal de sódio, dependente de voltagem, tipo X, subunidade alfa) ou Nav1.8 é uma proteína que nos humanos é codificada pelo gene com o mesmo nome. Nav1.8 é uma subunidade de canal de sódio. Este subtipo de canal de sódio dependente de voltagem tem a sua expressão efectuada em nociceptores e foi proposto como um alvo para o desenvolvimento de novos analgésicos. Em 2013, Bezzina & al mostraram que variantes comuns em -SCN10A e HEY2 estão associados à síndrome de Brugada. Nav1.8 is a sodium ion channel subtype that in humans is encoded by the SCN10A gene. Nav1.8-containing channels are tetrodotoxin (TTX)-resistant voltage-gated channels. Nav1.8 is expressed specifically in the dorsal root ganglion (DRG), in unmyelinated, small-diameter sensory neurons called C-fibres, and is involved in nociception. C-fibres can be activated by noxious thermal or mechanical stimuli and thus can carry pain messages. SCN10A (англ. Sodium voltage-gated channel alpha subunit 10) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 3-ї хромосоми. Довжина поліпептидного ланцюга білка становить 1 956 амінокислот, а молекулярна маса — 220 626. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин
sameAs	Nav1.8 Nav1.8 Nav1.8 Nav1.8 Nav1.8 Nav1.8 Nav1.8 Nav1.8
topic	dbr:Grasshopper_mouse dbr:Veratridine dbr:Nav1.9 dbr:Amitriptyline dbr:Orphenadrine dbr:PF-05089771 Melittin Sodium channel blocker Sodium channel Nav1.7 Brugada syndrome dbr:Cl6b dbr:Makatoxin-3 dbr:DSP-2230 dbr:APETx1 dbr:Evenamide dbr:Funapide dbr:SCN10A dbr:SCN10A_(gene) dbr:SCN5A dbr:GTx1-15 dbr:List_of_investigational_analgesics dbr:List_of_investigational_antipsychotics wikipedia-en:Nav1.8 dbr:DKK-Sp1 dbr:Syb-prII-1 dbr:Nav1.8#this dbr:N58A
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described by	https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Pain https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Hyperalgesia https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Chronic_pain https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Template:Infobox_gene https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Protein_kinase_C https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Analgesic proxy:entity/http/dbpedia.org/resource/Central_nervous_system
Subject	Ion channels dbc:Sodium_channels
dbo:wikiPageID	18418966(xsd:integer)
dbo:wikiPageRevisionID	1116891218(xsd:integer)
dbo:wikiPageWikiLink	analgesic Hyperalgesia Cre-Lox recombination Small fiber peripheral neuropathy dbr:Prostaglandin_E2_receptor Adenosine Cholesterol Dorsal root ganglion In vitro Myelin pain Serotonin Voltage clamp Allodynia central nervous system Group C nerve fiber In vivo Mutation Prostaglandin E2 Protein kinase C Protein targeting Tumor necrosis factor alpha Two-hybrid screening Tetraodontidae

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