About: RUNX2

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An Entity of Type : yago:Origin107323922, within Data Space : wasabi.inria.fr associated with source document(s)

Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that in humans is encoded by the RUNX2 gene. RUNX2 is a key transcription factor associated with osteoblast differentiation.

Attributes	Values
type	Thing biomolecule protein gene yago:Abstraction100002137 yago:Event100029378 yago:PsychologicalFeature100023100 yago:YagoPermanentlyLocatedEntity Biomolecule protein HumanGene dbo:Gene yago:Cause107326557 yago:Factor107327805 yago:WikicatTranscriptionFactors yago:Happening107283608 yago:Beginning107290905 yago:Origin107323922
label	RUNX2 RUNX2 RUNX2
comment	La proteína RUNX2, también denominada CBFA1, es un factor de transcripción clave asociado con la diferenciación de los osteoblastos, codificada en humanos por el gen runx2. RUNX2 pertenece a la familia de factores de transcripción RUNX y tiene un dominio Runt de unión a ADN. Es esencial en la diferenciación osteoblástica y en la morfogénesis del esqueleto, y actúa como una proteína estructural para los ácidos nucleicos y factores reguladores implicados en la expresión génica relacionada con el esqueleto. Esta proteína puede unir al ADN tanto en forma de monómero como formando parte de un complejo heteromérico, en este último caso, con mayor afinidad. Se han descrito diversas variantes transcripcionales del gen runx2 que codifican diferentes isoformas de la proteína, gracias al uso de prom Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that in humans is encoded by the RUNX2 gene. RUNX2 is a key transcription factor associated with osteoblast differentiation. RUNX2 (англ. Runt related transcription factor 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 6-ї хромосоми. Довжина поліпептидного ланцюга білка становить 521 амінокислот, а молекулярна маса — 56 648. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин
sameAs	RUNX2 RUNX2 RUNX2 RUNX2 RUNX2 RUNX2 RUNX2 RUNX2 RUNX2 RUNX2
topic	dbr:Runt_domain Prolactin-induced protein Prostate cancer ATF4 dbr:AML3 histone deacetylases RUNX1 dbr:Cleidocranial_dysostosis dbr:Adams–Oliver_syndrome dbr:Facial_skeleton dbr:Aml3 dbr:Cbfa1 dbr:Ccd1 dbr:Core_binding_factor STUB1 dbr:CBFA1 dbr:CBFB dbr:CCD1 dbr:GDF2 dbr:Runt-related_transcription_factor_2 dbr:Runx2 dbr:HDAC3 dbr:KAT6B List of OMIM disorder codes dbr:LRP5 List of genetic disorders dbr:List_of_human_protein-coding_genes_3 dbr:Osteochondroprogenitor_cell dbr:RUNX2_(gene) dbr:RUNX3 dbr:Sp7_transcription_factor wikipedia-en:RUNX2 dbr:Forkhead_box_protein_O1 dbr:Protein_c-Fos dbr:Transcription_factor_Jun dbr:Mohamadreza_Baghaban_Eslaminejad dbr:RUNX2#this
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described by	https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Gene_expression https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/class/yago/Beginning107290905 https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Mothers_against_decapentaplegic_homolog_1 https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/ATF4 https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Template:MeshName proxy:entity/http/dbpedia.org/resource/Cell_cycle https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/class/yago/Cause107326557 proxy:entity/http/dbpedia.org/resource/Protein https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Knockout_mouse https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/G2_phase https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Template:Infobox_gene https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Gene https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Cyclin_D/Cdk4 https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Cellular_differentiation
subject	Transcription factors
dbo:wikiPageID	7725171(xsd:integer)
Wikipage revision ID	1090805065(xsd:integer)
dbo:wikiPageWikiLink	C-jun G1 phase Myc dbr:Runt_domain dbr:Protein-protein_interaction cell cycle Kinase Osteoblast Transcription factor ATF4

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