About: Type IV collagen   Goto Sponge  NotDistinct  Permalink

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Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C-terminus is not removed in post-translational processing, and the fibers link head-to-head, rather than in parallel. Also, collagen IV lacks the regular glycine in every third residue necessary for the tight, collagen helix. This makes the overall arrangement more sloppy with kinks. These two features cause the collagen to form in a sheet, the form of the basal lamina. Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen". Collagen IV exists in all metazoan phyla, to whom they served as an evolutionary stepping stone to multicellularity.

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  • Type IV collagen
  • Colágeno tipo IV
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  • Colágeno tipo IV (ColIV or Col4) é um tipo de colágeno encontrado primariamente na lâmina basal. O domínio C4 na ponta C-terminal do colágeno IV não é removido no processo pós-traducional e as fibras se ligam cabeça-a-cabeça em vez de em paralelo. Além disso, o colágeno IV não possui glicinas regulares a cada 3 resíduos, necessárias para a hélice rígida do colágeno. Isso deixa o arranjo final mais "desleixado", com torções. Essas duas características levam à formação de uma folha, que forma a lâmina basal. Há 6 genes humanos associados com ele: * COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6
  • Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C-terminus is not removed in post-translational processing, and the fibers link head-to-head, rather than in parallel. Also, collagen IV lacks the regular glycine in every third residue necessary for the tight, collagen helix. This makes the overall arrangement more sloppy with kinks. These two features cause the collagen to form in a sheet, the form of the basal lamina. Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen". Collagen IV exists in all metazoan phyla, to whom they served as an evolutionary stepping stone to multicellularity.
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