About: Predictive factors of mortality in patients treated with tocilizumab for acute respiratory distress syndrome related to coronavirus disease 2019 (COVID-19)

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About: Predictive factors of mortality in patients treated with tocilizumab for acute respiratory distress syndrome related to coronavirus disease 2019 (COVID-19) Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Predictive factors of mortality in patients treated with tocilizumab for acute respiratory distress syndrome related to coronavirus disease 2019 (COVID-19)
Creator	Badie, Julio Balblanc, Jean-Charles Bossert, Marie Bozgan, Ana-Maria Bourgoin, Charlotte Charpentier, Aline Conrozier, Thierry Contreras, Remy Gendrin, Vincent Klopfenstein, Timothée Lohse, Anne Mazurier, Isabelle Royer, Pierre-Yves Zayet, Souheil Badie, J Balblanc, J.-C Bossert, M Bourgoin, C Bozgan, A.-M Charpentier, A Conrozier, T Contreras, R Gendrin, V Klopfenstein, T Mazurier, I Royer, P.-Y Souheil, Zayet, S
Source	Elsevier; Medline; PMC
abstract	COVID-19 patients (n=34) suffering from ARDS were treated with tocilizumab (TCZ). Outcome was classified in two groups: “Death” and “Recovery”. Predictive factors of mortality were studied. Mean age was 75.3, mean oxygen (O(2)) requirements 10.4 l/min. At baseline, all patients had multiple biological abnormalities (lymphopenia, increased CRP, ferritin, fibrinogen, D-dimer and liver enzymes). 24 patients (70.5%) recovered after TCZ therapy and 10 died (29.5%). Deceased subjects differed from patients in whom treatment was effective with regard to more pronounced lymphopenia (0.6 vs 1.0 G/l; p=0.037), lower platelet number (156 vs 314 G/l; p=0.0001), lower fibrinogen serum level (0.6 vs 1.0 G/l; p=0.03), higher aspartate-amino-transferase (108 vs 57 UI/l; p=0.05) and greater O(2) requirements (11 vs 8 l/min; p= 0.003).
has issue date	2020-06-20(xsd:dateTime)
bibo:doi	10.1016/j.micinf.2020.06.005
bibo:pmid	32574789
has license	no-cc
sha1sum (hex)	0d5b4b876357c050c7716a1c8c2456306c90aaf3
schema:url	https://doi.org/10.1016/j.micinf.2020.06.005
resource representing a document's title	Predictive factors of mortality in patients treated with tocilizumab for acute respiratory distress syndrome related to coronavirus disease 2019 (COVID-19)
has PubMed Central identifier	PMC7305501
has PubMed identifier	32574789
schema:publication	Microbes Infect
resource representing a document's body	covid:0d5b4b876357c050c7716a1c8c2456306c90aaf3#body_text
is schema:about of	named entity 'min' named entity 'min' named entity 'lymphopenia' named entity 'patients' named entity 'platelet' named entity 'Recovery' named entity 'treated' named entity 'therapy' named entity 'greater' named entity 'maladies' named entity 'Journal' named entity 'lymphopenia' named entity 'transferase' named entity 'ferritin' named entity 'COVID-19' named entity 'serum level' named entity 'tocilizumab' named entity 'G/l' named entity 'Title page' named entity 'intensivists' named entity 'alanine' named entity 'AST' named entity 'anticoagulant' named entity 'gamma glutamyltransferase' named entity 'COVID' named entity 'Acute respiratory distress syndrome' named entity 'COVID-19 outbreak' named entity 'COVID' named entity 'electrolytes' named entity 'severe pneumonia' named entity 'laboratory tests' named entity 'bronchial' named entity 'superinfection' named entity 'infection' named entity 'tumor' named entity 'tocilizumab' named entity 'prothrombin' named entity 'latent tuberculosis' named entity 'bilirubin' named entity 'control group' named entity 'hypersensitivity' named entity 'severe pneumonia' named entity 'prognostic' named entity 'lymphopenia' named entity 'CT-scan' named entity 'rheumatologist' named entity 'organ' named entity 'ARDS' named entity 'IL-2' named entity 'Lung' named entity 'NFC' named entity 'sputum' named entity 'Oxygen saturation' named entity 'methylprednisolone'

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