About: COVID-19 patients (n=34) suffering from ARDS were treated with tocilizumab (TCZ). Outcome was classified in two groups: “Death” and “Recovery”. Predictive factors of mortality were studied. Mean age was 75.3, mean oxygen (O(2)) requirements 10.4 l/min. At baseline, all patients had multiple biological abnormalities (lymphopenia, increased CRP, ferritin, fibrinogen, D-dimer and liver enzymes). 24 patients (70.5%) recovered after TCZ therapy and 10 died (29.5%). Deceased subjects differed from patients in whom treatment was effective with regard to more pronounced lymphopenia (0.6 vs 1.0 G/l; p=0.037), lower platelet number (156 vs 314 G/l; p=0.0001), lower fibrinogen serum level (0.6 vs 1.0 G/l; p=0.03), higher aspartate-amino-transferase (108 vs 57 UI/l; p=0.05) and greater O(2) requirements (11 vs 8 l/min; p= 0.003).   Goto Sponge  NotDistinct  Permalink

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  • COVID-19 patients (n=34) suffering from ARDS were treated with tocilizumab (TCZ). Outcome was classified in two groups: “Death” and “Recovery”. Predictive factors of mortality were studied. Mean age was 75.3, mean oxygen (O(2)) requirements 10.4 l/min. At baseline, all patients had multiple biological abnormalities (lymphopenia, increased CRP, ferritin, fibrinogen, D-dimer and liver enzymes). 24 patients (70.5%) recovered after TCZ therapy and 10 died (29.5%). Deceased subjects differed from patients in whom treatment was effective with regard to more pronounced lymphopenia (0.6 vs 1.0 G/l; p=0.037), lower platelet number (156 vs 314 G/l; p=0.0001), lower fibrinogen serum level (0.6 vs 1.0 G/l; p=0.03), higher aspartate-amino-transferase (108 vs 57 UI/l; p=0.05) and greater O(2) requirements (11 vs 8 l/min; p= 0.003).
Subject
  • COVID-19
  • Chemical pathology
  • Diagnostic intensive care medicine
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