About: Animal models of mechanisms of SARS‐CoV‐2 infection and COVID‐19 pathology

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About: Animal models of mechanisms of SARS‐CoV‐2 infection and COVID‐19 pathology Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Animal models of mechanisms of SARS‐CoV‐2 infection and COVID‐19 pathology
Creator	Page, Clive Pitchford, Simon Looney, Mark Amison, Richard Cabrera, Robaina Carrington, Robert Cleary, Simon Gray, Elaine Lorena, C Magnen, Mélia
Source	Medline; PMC
abstract	The coronavirus disease 2019 (COVID‐19) pandemic caused by SARS‐CoV‐2 infections has led to substantial unmet need for treatments, many of which will require testing in appropriate animal models of this disease. Vaccine trials are already underway, but there remains an urgent need to find other therapeutic approaches to either target SARS‐CoV‐2 or the complications arising from viral infection, particularly the dysregulated immune response and systemic complications which have been associated with progression to severe COVID‐19. At the time of writing, in vivo studies of SARS‐CoV‐2 infection have been described using macaques, cats, ferrets, hamsters, and transgenic mice expressing human angiotensin I converting enzyme 2 (ACE2). These infection models have already been useful for studies of transmission and immunity, but to date only partially model the mechanisms implicated in human severe COVID‐19. There is therefore an urgent need for development of animal models for improved evaluation of efficacy of drugs identified as having potential in the treatment of severe COVID‐19. These models need to recapitulate key mechanisms of COVID‐19 severe acute respiratory distress syndrome and reproduce the immunopathology and systemic sequelae associated with this disease. Here, we review the current models of SARS‐CoV‐2 infection and COVID‐19‐related disease mechanisms and suggest ways in which animal models can be adapted to increase their usefulness in research into COVID‐19 pathogenesis and for assessing potential treatments.
has issue date	2020-05-27(xsd:dateTime)
bibo:doi	10.1111/bph.15143
bibo:pmid	32462701
has license	no-cc
sha1sum (hex)	0fe5f0eea1c0a6a437b8c0108ff52fd71f8f6b0f
schema:url	https://doi.org/10.1111/bph.15143
resource representing a document's title	Animal models of mechanisms of SARS‐CoV‐2 infection and COVID‐19 pathology
has PubMed Central identifier	PMC7283621
has PubMed identifier	32462701
schema:publication	Br J Pharmacol
resource representing a document's body	covid:0fe5f0eea1c0a6a437b8c0108ff52fd71f8f6b0f#body_text
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