About: COVID-19 Outcomes in 4712 consecutively confirmed SARS-CoV2 cases in the city of Madrid.

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About: COVID-19 Outcomes in 4712 consecutively confirmed SARS-CoV2 cases in the city of Madrid. Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	COVID-19 Outcomes in 4712 consecutively confirmed SARS-CoV2 cases in the city of Madrid.
Creator	González Mangado, Nicolás Jesús, María Muñoz, Luis Peces-Barba, Germán Petkova, Elizabet Cabello Úbeda, Alfonso Carrasco, Nerea De La Fuente, Lorena Del Pilar Carballosa De Miguel, María Ezzine De Blas, Farah Fernández Ormaechea, Itziar Fjd-Team, Covid Górgolas Hernández-Mora, Miguel Heili-Frades, Sarah Herrero González, Antonio Hiscock, Luis, Jiménez Mahillo Fernández, Ignacio Minguez, Pablo Naya Prieto Md, Alba Nieto, Rodríguez Peces-Barba, Mario Perez Calvo, Cesar Prieto-Rumeau, Tomás Romero Bueno, Fredeswinda Romero, Ríos, Dolores Santos, Arnoldo Sánchez Pernaute, Olga
Source	MedRxiv
abstract	There is limited information describing features and outcomes of patients requiring hospitalization for COVID19 disease and still no treatments have clearly demonstrated efficacy. Demographics and clinical variables on admission, as well as laboratory markers and therapeutic interventions were extracted from electronic Clinical Records (eCR) in 4712 SARS-CoV2 infected patients attending 4 public Hospitals in Madrid. Patients were stratified according to age and stage of severity. Using multivariate logistic regression analysis, cut-off points that best discriminated mortality were obtained for each of the studied variables. Principal components analysis and a neural network (NN) algorithm were applied. A high mortality incidence associated to age >70, comorbidities (hypertension, neurological disorders and diabetes), altered vitals such as fever, heart rhythm disturbances or elevated systolic blood pressure, and alterations in several laboratory tests. Remarkably, analysis of therapeutic options either taken individually or in combination drew a universal relationship between the use of Cyclosporine A and better outcomes as also a benefit of tocilizumab and/or corticosteroids in critically ill patients. We present a large Spanish population-based study addressing factors influencing survival in current SARS CoV2 pandemic, with particular emphasis on the effectivity of treatments. In addition, we have generated an NN capable of identifying severity predictors of SARS CoV2. A rapid extraction and management of data protocol from eCR and artificial intelligence in-house implementations allowed us to perform almost real time monitoring of the outbreak evolution.
has issue date	2020-05-25(xsd:dateTime)
bibo:doi	10.1101/2020.05.22.20109850
has license	medrxiv
sha1sum (hex)	16f7e69f1dc6823620bf0950bb6fee14dcb039d0
schema:url	https://doi.org/10.1101/2020.05.22.20109850
resource representing a document's title	COVID-19 Outcomes in 4712 consecutively confirmed SARS-CoV2 cases in the city of Madrid.
resource representing a document's body	covid:16f7e69f1dc6823620bf0950bb6fee14dcb039d0#body_text
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