About: Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid

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About: Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid
Creator	Gut, Jiri Schirmeister, Tanja Dude, Marie-Adrienne Gelhaus, Christoph Heppner, Saskia Herb, Monika Kaeppler, Ulrich Leippe, Matthias Pradel, Gabriele Schiller, Markus Schulz, Franziska Vedder, Birgit Rosenthal, Philip
source	Medline; PMC
abstract	A series of etacrynic acid derivatives was synthesized and screened for their in vitro activity against Plasmodium falciparum, as well as their activity against recombinantly expressed falcipain-2 and -3. The two most active compounds of the series displayed IC(50) values of 9.0 and 18.8 μM against Plasmodia.
has issue date	2008-12-23(xsd:dateTime)
bibo:doi	10.3390/molecules14010019
bibo:pmid	19104483
has license	cc-by
sha1sum (hex)	318eb743359acf11f860f81255d3a1625f33e484
schema:url	https://doi.org/10.3390/molecules14010019
resource representing a document's title	Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid
has PubMed Central identifier	PMC6253875
has PubMed identifier	19104483
schema:publication	Molecules
resource representing a document's body	covid:318eb743359acf11f860f81255d3a1625f33e484#body_text
is schema:about of	named entity 'ETACRYNIC ACID' named entity 'ETACRYNIC ACID' named entity 'IN VITRO ACTIVITY' named entity 'ACTIVITY' named entity 'DISPLAYED' named entity 'PLASMODIUM FALCIPARUM' named entity 'DERIVED' named entity 'SYNTHESIS' named entity 'EXPRESSED' named entity 'VALUES' named entity 'THEIR' named entity 'EVALUATION' named entity 'NON-' named entity 'MOLECULES' named entity 'CYSTEINE PROTEASE INHIBITORS' named entity 'FALCIPAIN-2' named entity 'SYNTHESIZED' named entity 'BCM' named entity 'ACTIVE' named entity 'SERIES' named entity 'P. FALCIPARUM' covid:arg/318eb743359acf11f860f81255d3a1625f33e484 named entity 'activity' named entity 'Etacrynic Acid' named entity 'P. falciparum' named entity 'mmol' named entity 'P. falciparum' named entity 'vaccine' named entity 'peptidic' named entity 'DMSO' named entity 'N-hydroxysuccinimide' named entity 'parasites' named entity 'phenolic' named entity 'E-64' named entity 'enzyme' named entity 'acetic anhydride' named entity 'Deisenhofen' named entity 'mmol' named entity 'MeOH' named entity 'THF' named entity 'Hoechst' named entity 'amide' named entity 'drug resistance' named entity 'formaldehyde' named entity 'organic solvent' named entity 'fetal bovine serum' named entity 'Giessen' named entity 'complexation' named entity 'etacrynic acid' named entity 'biotin' named entity 'negative control' named entity 'reflux' named entity 'mmol' named entity 'reaction mixture' named entity 'AVANCE' named entity 'Amine' named entity 'room temperature' named entity 'chloroquine' named entity 'butyric acid' named entity 'recombinantly expressed' named entity 'fluoro' named entity 'DMSO' named entity 'cysteine protease inhibitor' named entity 'cysteine protease inhibitor' named entity 'parasite' named entity 'moiety' named entity 'dichloromethane' named entity 'H-NMR' named entity 'free acid'

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