About: A series of etacrynic acid derivatives was synthesized and screened for their in vitro activity against Plasmodium falciparum, as well as their activity against recombinantly expressed falcipain-2 and -3. The two most active compounds of the series displayed IC(50) values of 9.0 and 18.8 μM against Plasmodia.   Goto Sponge  NotDistinct  Permalink

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  • A series of etacrynic acid derivatives was synthesized and screened for their in vitro activity against Plasmodium falciparum, as well as their activity against recombinantly expressed falcipain-2 and -3. The two most active compounds of the series displayed IC(50) values of 9.0 and 18.8 μM against Plasmodia.
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  • Malaria
  • Plasmodium
  • Disulfiram-like drugs
  • World Anti-Doping Agency prohibited substances
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