About: Angiotensin-converting enzyme 2 protects from severe acute lung failure

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Angiotensin-converting enzyme 2 protects from severe acute lung failure
Creator	Yang, Peng Imai, Yumiko Kuba, Keiji Jiang, Chengyu Guo, Feng Fukamizu, Akiyoshi Rao, Shuan Uhlig, Stefan Crackower, Michael Guan, Bin Huan, Yi Penninger, Josef Slutsky, Arthur Wada, Teiji Hein, Lutz Hui, Chi-Chung Leong-Poi, Howard Sarao, Renu
topic	covid:5aa948a8142d15169418ccdd4c38be81be85ca37#this
Source	Medline; PMC
abstract	Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury, is a devastating clinical syndrome with a high mortality rate (30–60%) (refs 1–3). Predisposing factors for ARDS are diverse(1,3) and include sepsis, aspiration, pneumonias and infections with the severe acute respiratory syndrome (SARS) coronavirus(4,5). At present, there are no effective drugs for improving the clinical outcome of ARDS(1,2,3). Angiotensin-converting enzyme (ACE) and ACE2 are homologues with different key functions in the renin–angiotensin system(6,7,8). ACE cleaves angiotensin I to generate angiotensin II, whereas ACE2 inactivates angiotensin II and is a negative regulator of the system. ACE2 has also recently been identified as a potential SARS virus receptor and is expressed in lungs(9,10). Here we report that ACE2 and the angiotensin II type 2 receptor (AT(2)) protect mice from severe acute lung injury induced by acid aspiration or sepsis. However, other components of the renin–angiotensin system, including ACE, angiotensin II and the angiotensin II type 1a receptor (AT(1)a), promote disease pathogenesis, induce lung oedemas and impair lung function. We show that mice deficient for Ace show markedly improved disease, and also that recombinant ACE2 can protect mice from severe acute lung injury. Our data identify a critical function for ACE2 in acute lung injury, pointing to a possible therapy for a syndrome affecting millions of people worldwide every year. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nature03712) contains supplementary material, which is available to authorized users.
has issue date	2005-01-01(xsd:dateTime)
bibo:doi	10.1038/nature03712
bibo:pmid	16001071
has license	no-cc
sha1sum (hex)	5aa948a8142d15169418ccdd4c38be81be85ca37
schema:url	https://doi.org/10.1038/nature03712
resource representing a document's title	Angiotensin-converting enzyme 2 protects from severe acute lung failure
has PubMed Central identifier	PMC7094998
has PubMed identifier	16001071
schema:publication	Nature
resource representing a document's body	covid:5aa948a8142d15169418ccdd4c38be81be85ca37#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/5aa948a8142d15169418ccdd4c38be81be85ca37
is schema:about of	named entity 'LUNG' named entity 'ACE2' named entity 'lung' named entity 'functions' named entity 'PATHOGENESIS' named entity 'INFECTIONS' named entity 'SYNDROME' named entity 'SYSTEM' named entity 'OUTCOME' named entity 'FORM' named entity 'THERAPY' named entity 'ACE' named entity 'KEY' named entity 'OUR' named entity 'REPORT' named entity 'IS A' named entity '2C5' named entity 'LUNG FUNCTION' named entity 'ANGIOTENSIN-CONVERTING ENZYME' named entity 'DRUGS' named entity 'GENERATE' named entity 'LUNG' named entity 'FUNCTION' named entity 'PRESENT' named entity 'LUNGS' named entity 'EFFECTIVE' named entity 'II TYPE' named entity 'ANGIOTENSIN I' named entity 'SEPSIS' named entity 'ANGIOTENSIN II' named entity 'SARS VIRUS' named entity 'TYPE 2' named entity 'CORONAVIRUS' named entity 'CRITICAL' named entity 'DISEASE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'ACUTE RESPIRATORY DISTRESS SYNDROME' named entity 'DEFICIENT' named entity 'PREDISPOSING FACTORS' named entity 'POTENTIAL' named entity 'MORTALITY RATE' named entity 'RENIN-ANGIOTENSIN SYSTEM' named entity 'OEDEMAS' named entity 'PNEUMONIAS' named entity 'EXPRESSED' named entity '60%' named entity 'ACUTE' named entity 'SEVERE' named entity 'DIFFERENT' named entity 'CLEAVES' named entity 'ACID ASPIRATION' named entity 'POINTING' named entity 'IMPAIR' named entity 'ARDS' named entity 'IDENTIFY' named entity 'SEVERE' named entity 'INDUCE' named entity 'IMPROVED' named entity 'INCLUDE' named entity 'VIRUS RECEPTOR' named entity 'RECENTLY' named entity 'AFFECTING'

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