About: Seneca Valley Virus 3C protease negatively regulates the type I interferon pathway by acting as a viral deubiquitinase

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About: Seneca Valley Virus 3C protease negatively regulates the type I interferon pathway by acting as a viral deubiquitinase Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Seneca Valley Virus 3C protease negatively regulates the type I interferon pathway by acting as a viral deubiquitinase
Creator	Yang, Fan Zheng, Haixue Cai, Xuepeng Liu, Huisheng Xue, Qiao Xue, Qinghong Liu, Xiangtao Zhu, Zixiang
Source	Elsevier; Medline; PMC
abstract	Abstract The mechanisms that enable Seneca Valley Virus (SVV) to escape the host innate immune response are not well known. Previous studies demonstrated that SVV 3Cpro suppresses innate immune responses by cleavage of host proteins and degradation of IRF3 and IRF7 protein expression. Here, we showed that SVV 3C protease (3Cpro) has deubiquitinating activity. Overexpressed 3Cpro inhibits the ubiquitination of cellular substrates, acting on both lysine-48- and lysine-63-linked polyubiquitin chains. SVV infection also possessed deubiquitinating activity. The ubiquitin-proteasome system was significantly involved in SVV replication. Furthermore, 3Cpro inhibited the ubiquitination of retinoic acid-inducible gene I (RIG-I), TANK-binding kinase 1 (TBK1), and TNF receptor-associated factor 3 (TRAF3), thereby blocking the expression of interferon (IFN)-β and IFN stimulated gene 54 (ISG54) mRNAs. A detailed analysis revealed that mutations (H48A, C160A, or H48A/C160A) that ablate the Cys and His residues of 3Cpro abrogated its deubiquitinating activity and the ability of 3Cpro to block IFN-β induction. Together, our results demonstrate a novel mechanism developed by SVV 3Cpro to promote viral replication, and may also provide a novel strategy for improving ubiquitination-based therapy.
has issue date	2018-12-31(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2018.10.028
bibo:pmid	30408499
has license	els-covid
sha1sum (hex)	995d2bb3b94e40338961672f61cd66b6893763df
schema:url	https://doi.org/10.1016/j.antiviral.2018.10.028
resource representing a document's title	Seneca Valley Virus 3C protease negatively regulates the type I interferon pathway by acting as a viral deubiquitinase
has PubMed Central identifier	PMC7111287
has PubMed identifier	30408499
schema:publication	Antiviral Research
resource representing a document's body	covid:995d2bb3b94e40338961672f61cd66b6893763df#body_text
is schema:about of	named entity 'pro' named entity 'replication' named entity 'TBK1' named entity 'innate immune responses' named entity 'activity' named entity 'studies' named entity 'SVV' named entity 'pro' covid:arg/995d2bb3b94e40338961672f61cd66b6893763df named entity 'cellular' named entity 'ubiquitination' named entity 'mechanisms' named entity 'stimulated' named entity 'detailed' named entity 'TANK-binding kinase 1' named entity 'IRF3' named entity 'ablate' named entity 'abrogated' named entity 'block' named entity 'mutations' named entity 'ubiquitination' named entity 'deubiquitinase' named entity 'deubiquitinating' named entity 'ubiquitination' named entity 'SVV' named entity 'lysine' named entity 'IFN' named entity 'protease' named entity 'IFN' named entity 'protein expression' named entity 'IRF3' named entity 'homology' named entity 'virus' named entity 'immunoprecipitated' named entity 'viral infection' named entity 'cell culture' named entity 'RIG-I' named entity 'proteases' named entity 'Ubiquitination' named entity 'SVV' named entity 'ubiquitination' named entity 'viruses' named entity 'RIG-I' named entity 'transfected' named entity 'infection' named entity 'immunoprecipitated' named entity 'conjugation' named entity 'TBK1' named entity 'immunoprecipitated' named entity 'hpi' named entity 'standard deviations' named entity 'PRRS' named entity 'plasmid' named entity 'western blotting' named entity 'papain' named entity 'SVV' named entity 'light chain' named entity 'substrates' named entity 'antiviral' named entity 'PRRSV' named entity 'Myc' named entity 'viral RNA' named entity 'primers' named entity 'innate immune' named entity 'plasmid' named entity 'TRAF3' named entity 'immunoprecipitation' named entity 'RIG-I' named entity 'TRAF3' named entity 'SVV' named entity 'vector' named entity 'vector' named entity 'cell lysates' named entity 'endogenous'

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