About: Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation

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About: Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation
Creator	Guan, Yi Danesh, Ali Xu, Luoling Fang, Yuan Ran, Longsi Rowe, Thomas Chen, Honglin Cameron, Cheryl Kelvin, David Cameron, Mark Jonsson, Colleen Kelvin, Alyson León, Alberto
Source	Elsevier; Medline; PMC
abstract	Abstract Type I interferons (IFNs) are essential to the clearance of viral diseases, however, a clear distinction between genes upregulated by direct virus–cell interactions and genes upregulated by secondary IFN production has not been made. Here, we investigated differential gene regulation in ferrets upon subcutaneous administration of IFN-α2b and during SARS-CoV infection. In vivo experiments revealed that IFN-α2b causes STAT1 phosphorylation and upregulation of abundant IFN response genes (IRGs), chemokine receptors, and other genes that participate in phagocytosis and leukocyte transendothelial migration. During infection with SARS-CoV not only a variety of IRGs were upregulated, but also a significantly broader range of genes involved in cell migration and inflammation. This work allowed dissection of several molecular signatures present during SARS-CoV which are part of a robust IFN antiviral response. These signatures can be useful markers to evaluate the status of IFN responses during a viral infection and specific features of different viruses.
has issue date	2011-01-05(xsd:dateTime)
bibo:doi	10.1016/j.virol.2010.10.002
bibo:pmid	21035159
has license	els-covid
sha1sum (hex)	f508f5a7c736788eb798ee76553b33b887882e63
schema:url	https://doi.org/10.1016/j.virol.2010.10.002
resource representing a document's title	Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation
has PubMed Central identifier	PMC7111932
has PubMed identifier	21035159
schema:publication	Virology
resource representing a document's body	covid:f508f5a7c736788eb798ee76553b33b887882e63#body_text
is schema:about of	named entity 'INTERFERON-ALPHA2B' named entity 'specific' named entity 'molecular signatures' named entity 'cell migration' named entity 'expression' named entity 'EVENTS' named entity 'PHOSPHORYLATION' named entity 'STATUS' named entity 'UPREGULATED' named entity 'PRODUCTION' named entity 'CHEMOKINE RECEPTORS' named entity 'BUT' named entity 'DIFFERENT' named entity 'UPREGULATION' named entity 'FERRETS' named entity 'DISSECTION' named entity 'CELL MIGRATION' named entity 'TYPE I INTERFERONS' named entity 'IFN' named entity 'SIGNATURES' named entity 'HERE' named entity 'USEFUL' named entity 'STAT1' named entity 'PHAGOCYTOSIS' named entity 'DIRECT' named entity 'DIRECT' named entity 'CAUSES' named entity 'WORK' named entity 'CORONAVIRUS INFECTION' named entity 'GENE EXPRESSION' named entity 'RESPONSE TO' named entity 'STIMULATION' named entity 'CLEARANCE' named entity 'EXPERIMENTS' named entity 'INTERACTIONS' named entity 'MOLECULAR' named entity 'GENES' named entity 'SECONDARY' named entity 'LEUKOCYTE TRANSENDOTHELIAL MIGRATION' named entity 'SARS-COV' named entity 'VIRUSES' named entity 'MARKERS' named entity 'INVESTIGATED' named entity 'PRESENT' named entity 'THESE' named entity 'ESSENTIAL' named entity 'CELL' named entity 'SPECIFIC' named entity 'SARS-COV INFECTION' named entity 'VIRUS' named entity 'INFECTION' named entity 'EARLY GENE' named entity 'SUBCUTANEOUS ADMINISTRATION' named entity 'EVALUATE' named entity 'RANGE' named entity 'IN VIVO' named entity 'VIRAL DISEASES' named entity 'GENE REGULATION' named entity 'PART OF' named entity 'ALLOWED' named entity 'IRGS' named entity 'INVOLVED' named entity 'ANTIVIRAL RESPONSE' named entity 'SARS CORONAVIRUS' named entity 'ABUNDANT' named entity 'INFLAMMATION' named entity 'VIRAL INFECTION' named entity 'CLEAR' named entity 'FERRETS'

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