Metadata about: [Image: see text] SARS-CoV-2 encoded papain-like protease (PLpro) harbors a labile Zn site (Cys(189)–X–X–Cys(192)–X(n)–Cys(224)–X–Cys(226)) and a classic catalytic site (Cys(111)–His(272)–Asp(286)), which play key roles for viral replication and hence represent promising drug targets. In this Viewpoint, both sulfur-based drugs and peptides-based inhibitors may block Cys residues in the catalytic and/or Zn site of CoV-2-PLpro, leading to dysfunction of CoV-2-PLpro and thereby halting viral replication.

About: [Image: see text] SARS-CoV-2 encoded papain-like protease (PLpro) harbors a labile Zn site (Cys(189)–X–X–Cys(192)–X(n)–Cys(224)–X–Cys(226)) and a classic catalytic site (Cys(111)–His(272)–Asp(286)), which play key roles for viral replication and hence represent promising drug targets. In this Viewpoint, both sulfur-based drugs and peptides-based inhibitors may block Cys residues in the catalytic and/or Zn site of CoV-2-PLpro, leading to dysfunction of CoV-2-PLpro and thereby halting viral replication.

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