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Helenalin, or (-)-4-Hydroxy-4a,8-dimethyl-3,3a,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione, is a toxic sesquiterpene lactone which can be found in several plants such as Arnica montana and Arnica chamissonis Helenalin is responsible for the toxicity of the Arnica spp. Although toxic, helenalin possesses some in vitro anti-inflammatory and anti-neoplastic effects. Helenalin can inhibit certain enzymes, such as 5-lipoxygenase and leukotriene C4 synthase. For this reason the compound or its derivatives may have potential medical applications.

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type
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  • Helenalin
  • Elenalina
  • Helenalin
  • Helenalina
  • Hélénaline
  • ヘレナリン
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  • L'hélénaline est un lactone sesquiterpenique, constituant majeur de Arnica montana et de Arnica chamissonis subsp foliosa. Avec la dihydrohélénaline, responsables de l'amertume, elles semblent être les constituants produisant les propriétés anti-inflammatoires et analgésiques de ces plantes. Plus précisément, l'hélénaline est un puissant inhibiteur du facteur de transcription nucléaire NF-kB, un facteur crucial du processus inflammatoire.
  • ヘレナリン(Helenalin)は、のArnica montanaやArnica chamissonisに含まれるセスキテルペンラクトンである。毒性が高く、肝臓やリンパ管の組織は、特にその影響に弱い。ウサギギク属の持つ毒性、皮膚炎症の主原因であると考えられている。ヘレナリンを含む多量の植物を摂取すると、重篤な胃腸炎や消化管内出血を引き起こす。
  • Helenalin ist ein natürlicher Entzündungshemmer mit Antitumor- und antileukämischer Wirkung, der in Arnika und anderen Asteraceae vorkommt. Es unterdrückt die Aktivierung eines Immunabwehrvermittlers und ist giftig. Chemisch handelt es sich um ein Sesquiterpen-Lacton. Helenalin ist neben der Bergarnika (Arnica montana) auch in anderen Arniken (etwa ), Wasserhanf (Eupatorium perfoliatum), der Großen Kapuzinerkresse (Tropaeolum majus) – alle im Kraut – sowie im Echten Alant (Inula helenium) – dort auch in der Wurzel – nachgewiesen.
  • Helenalina es una lactona sesquiterpenica con potentes efectos antiinflamatorios y antitumorales, se encuentra en Arnica montana y Arnica chamissonis foliosa. Es el compuesto principal responsable de los efectos terapéuticos del Arnica. Aunque no está completamente dilucidado como las lactonas sesquiterpénicas ejercen sus efectos antiinflamatorios, la helenalina ha mostrado inhibir selectivamente el factor de transcripción NF-κB, que juega un rol clave en la regulación de la respuesta immune, a través de un mecanísmo único.​
  • L'elenalina è un lattone sesquiterpenico che si ritrova nell'Arnica montana e nell'Arnica chamissonis foliosa. L'elenalina è un composto altamente tossico e soprattutto i tessuti epatici e linfatici sono vulnerabili ai suoi effetti. Si ritiene che sia responsabile della tossicità e dell'irritazione a carico della pelle associato all'arnica. Se una quantità sufficiente della pianta viene ingerita, l'elenalina produce gravi effetti gastroenterici ed emorragia interna del tratto digestivo.
  • Helenalin, or (-)-4-Hydroxy-4a,8-dimethyl-3,3a,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione, is a toxic sesquiterpene lactone which can be found in several plants such as Arnica montana and Arnica chamissonis Helenalin is responsible for the toxicity of the Arnica spp. Although toxic, helenalin possesses some in vitro anti-inflammatory and anti-neoplastic effects. Helenalin can inhibit certain enzymes, such as 5-lipoxygenase and leukotriene C4 synthase. For this reason the compound or its derivatives may have potential medical applications.
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